Patents by Inventor Hansell H. Stedman

Hansell H. Stedman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9283357
    Abstract: A method for transferring a macromolecular complex to muscle cells by exsanguinating a region of the subject's microvasculature and delivering the complex to this region under high hydrostatic pressure. A balloon catheter having a balloon that extends substantially the full length of the cannula that is inserted into the subject is provided for use in the systemic delivery of macromolecular complex.
    Type: Grant
    Filed: February 13, 2015
    Date of Patent: March 15, 2016
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Hansell H. Stedman, Charles R. Bridges
  • Publication number: 20150224288
    Abstract: A method for transferring a macromolecular complex to muscle cells by exsanguinating a region of the subject's microvasculature and delivering the complex to this region under high hydrostatic pressure. A balloon catheter having a balloon that extends substantially the full length of the cannula that is inserted into the subject is provided for use in the systemic delivery of macromolecular complex.
    Type: Application
    Filed: February 13, 2015
    Publication date: August 13, 2015
    Inventors: Hansell H. Stedman, Charles R. Bridges
  • Patent number: 8986282
    Abstract: A method for transferring a macromolecular complex to muscle cells by exsanguinating a region of the subject's microvasculature and delivering the complex to this region under high hydrostatic pressure. A balloon catheter having a balloon that extends substantially the full length of the cannula that is inserted into the subject is provided for use in the systemic delivery of macromolecular complex.
    Type: Grant
    Filed: November 5, 2012
    Date of Patent: March 24, 2015
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Hansell H. Stedman, Charles R. Bridges
  • Patent number: 8556842
    Abstract: A perfusion circuit and a use thereof for delivering a substance to a subject's heart in situ during cardiopulmonary bypass surgery are provided. The perfusion circuit defines a path for re-circulating a solution containing a macromolecular complex through a coronary circulation circuit through a subject's heart during a surgical procedure in which the substance is prevented from being delivered to the subject's other organs.
    Type: Grant
    Filed: November 11, 2011
    Date of Patent: October 15, 2013
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Charles R. Bridges, Hansell H. Stedman, Charles Yarnall
  • Patent number: 8303567
    Abstract: A method for transferring a macromolecular complex to muscle cells by exsanguinating a region of the subject's microvasculature and delivering the complex to this region under high hydrostatic pressure. A balloon catheter having a balloon that extends substantially the full length of the cannula that is inserted into the subject is provided for use in the systemic delivery of macromolecular complex.
    Type: Grant
    Filed: January 18, 2011
    Date of Patent: November 6, 2012
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Hansell H. Stedman, Charles R. Bridges
  • Publication number: 20120053502
    Abstract: A perfusion circuit and a use thereof for delivering a substance to a subject's heart in situ during cardiopulmonary bypass surgery are provided. The perfusion circuit defines a path for re-circulating a solution containing a macromolecular complex through a coronary circulation circuit through a subject's heart during a surgical procedure in which the substance is prevented from being delivered to the subject's other organs.
    Type: Application
    Filed: November 11, 2011
    Publication date: March 1, 2012
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Charles R. BRIDGES, Hansell H. STEDMAN, Charles YARNALL
  • Publication number: 20110112510
    Abstract: A method for transferring a macromolecular complex to muscle cells by exsanguinating a region of the subject's microvasculature and delivering the complex to this region under high hydrostatic pressure. A balloon catheter having a balloon that extends substantially the full length of the cannula that is inserted into the subject is provided for use in the systemic delivery of macromolecular complex.
    Type: Application
    Filed: January 18, 2011
    Publication date: May 12, 2011
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Hansell H. Stedman, Charles R. Bridges
  • Patent number: 7771993
    Abstract: A microutrophin containing a utrophin having internal deletions (relative to a native utrophin) in the hinge regions and a C-terminal deletion is provided. Also provided are vectors and compositions useful for delivering the microutrophin for the treatment of muscular disorders, including Duchenne Muscular Dystrophy.
    Type: Grant
    Filed: January 21, 2005
    Date of Patent: August 10, 2010
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Hansell H. Stedman, Leonard T. Su, Marilyn A. Mitchell
  • Publication number: 20090054823
    Abstract: A perfusion circuit and a use thereof for delivering a substance to a subject's heart in situ during cardiopulmonary bypass surgery are provided. The perfusion circuit defines a path for re-circulating a solution containing a macromolecular complex through a coronary circulation circuit (50) through a subject's heart during a surgical procedure in which the substance is prevented from being delivered to the subject's other organs.
    Type: Application
    Filed: September 26, 2005
    Publication date: February 26, 2009
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Charles R. Bridges, Hansell H. Stedman, Charles Yarnall
  • Publication number: 20080242623
    Abstract: A microutrophin containing a utrophin having internal deletions (relative to a native utrophin) in the hinge regions and a C-terminal deletion is provided. Also provided are vectors and compositions useful for delivering the microutrophin for the treatment of muscular disorders, including Duchenne Muscular Dystrophy.
    Type: Application
    Filed: January 21, 2005
    Publication date: October 2, 2008
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Hansell H. Stedman, Leonard T. Su, Marilyn A. Mitchell
  • Patent number: 6673039
    Abstract: Compositions, methods, kits, and apparatus are provided for delivering a macromolecular assembly such as a plasmid, virus vector, or other gene vector, to an extravascular tissue such as muscle tissue. The composition comprises the macromolecular assembly and a vascular permeability-enhancing agent. In another embodiment, the composition further comprises a vasodilating agent. The method of the invention comprises proving a vascular permeability-enhancing agent to a blood vessel and providing a macromolecular assembly to the vessel. An oxygenator useful for providing oxygen to a fluid extracorporeally prior to providing the fluid to a blood vessel of a mammal is included in the invention. Kits, apparatus, and methods for using the catheters described herein for isolating cardiac circulation, diverting caval blood flow from the right atrium, and for other purposes, are also described.
    Type: Grant
    Filed: June 19, 2000
    Date of Patent: January 6, 2004
    Assignee: Trustees of the University of Pennsylvania
    Inventors: Charles R. Bridges, Hansell H. Stedman
  • Patent number: 6177403
    Abstract: Compositions, methods, and an apparatus are provided for delivering a macromolecular assembly such as a plasmid, virus vector, or other gene vector, to an extravascular tissue such as muscle tissue. The composition comprises the macromolecular assembly and a vascular permeability-enhancing agent. In another embodiment, the composition further comprises a vasodilating agent. The method of the invention comprises providing a vascular permeability-enhancing agent to a blood vessel and providing a macromolecular assembly to the vessel. An oxygenator useful for providing oxygen to a fluid extracorporeally prior to providing the fluid to a blood vessel of an animal is included in the invention.
    Type: Grant
    Filed: October 21, 1997
    Date of Patent: January 23, 2001
    Assignee: The Trustees of the University of Pennsylvania
    Inventor: Hansell H. Stedman