Patents by Inventor Hansen Bow

Hansen Bow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8771933
    Abstract: This invention provides methods utilizing a microfluidic device that can quickly and accurately discern differences in deformability between individual cells and sets of cells and continuously fractionate populations of cells based on their deformability. This information may be important in disease diagnosis and treatment efficacy monitoring. For example such a device may be able to determine the stage of malarial infection by using red blood cell deformability. Additionally, methods of the invention may be used as a tool to screen drugs that can make cells more flexible in diseases such as sickle cell anemia that causes sickle cell crises. The relatively low manufacturing and operation costs of methods of the invention enable this device to be used in resource-limited settings to diagnose and monitor disease.
    Type: Grant
    Filed: October 6, 2010
    Date of Patent: July 8, 2014
    Assignee: Massachusetts Institute of Technology
    Inventors: Jongyoon Han, Hansen Bow, Patrick Abgrall
  • Publication number: 20120064505
    Abstract: The invention in some aspects relates to methods, devices and compositions for evaluating material properties, such as mechanical and rheological properties of substances, particularly biological substances, such as cells, tissues, and biological fluids. In some aspects, the invention relates to methods, devices and compositions for evaluating material properties of deformable objects, such as cells. In further aspects, the invention relates to methods, devices and compositions for diagnosing and/or characterizing disease based on material properties of biological cells.
    Type: Application
    Filed: March 21, 2011
    Publication date: March 15, 2012
    Applicant: Massachusetts Institute of Technology
    Inventors: Subra Suresh, Jongyoon Han, Hansen Bow, Sha Huang, Monica Diez Silva, Igor V. Pivkin, Michal (Michelle) Berris, Ming Dao
  • Publication number: 20110081674
    Abstract: This invention provides methods utilizing a microfluidic device that can quickly and accurately discern differences in deformability between individual cells and sets of cells and continuously fractionate populations of cells based on their deformability. This information may be important in disease diagnosis and treatment efficacy monitoring. For example such a device may be able to determine the stage of malarial infection by using red blood cell deformability. Additionally, methods of the invention may be used as a tool to screen drugs that can make cells more flexible in diseases such as sickle cell anemia that causes sickle cell crises. The relatively low manufacturing and operation costs of methods of the invention enable this device to be used in resource-limited settings to diagnose and monitor disease.
    Type: Application
    Filed: October 6, 2010
    Publication date: April 7, 2011
    Inventors: Jongyoon HAN, Hansen Bow, Patrick Abgrall