Patents by Inventor Hanwen DENG
Hanwen DENG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240382612Abstract: The disclosure relates to a bioactive molecule conjugate, preparation methods and use thereof, particularly relates to a novel bioactive molecule conjugate obtained by improving coupling of the drug and the targeting moiety in an ADC or SMDC, as well as its preparation method and use in the manufacture of a medicament for the treatment of a disease associated with an abnormal cell activity.Type: ApplicationFiled: April 26, 2024Publication date: November 21, 2024Inventors: Jiaqiang CAI, Shuai SONG, Tongtong XUE, Liang XIAO, Hanwen DENG, Qiang TIAN, Jing WANG, Dengnian LIU, Liping LIU, Haimin YU, Zhouning YANG, Xu CAO, Guoqing ZHONG, Lichun WANG, Jingyi WANG
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Publication number: 20240269312Abstract: Provided in the present application are an antibody-drug conjugate, and a preparation method therefor and the use thereof. The antibody drug conjugate has a structure as represented by the formula Ab-[M-L-E-D]x, and the drug is selected from an anti-tubulin agent, a DNA intercalator, a DNA topoisomerase inhibitor and a RNA polymerase inhibitor. The prepared antibody-drug conjugate has a better drug-to-antibody ratio, and has a good targeted killing effect on colon cancer and non-small cell lung cancer (for example, lung adenocarcinoma).Type: ApplicationFiled: May 23, 2022Publication date: August 15, 2024Applicants: SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD., KLUS PHARMA INC.Inventors: Haijun TIAN, Qiang TIAN, Xiaoxi YUAN, Ying-Hua CHANG, Deliang LI, Jiangjiang HU, Yitao ZHANG, Xiaobei WANG, Yong ZHENG, Jian YE, Bo WANG, Yu MIAO, Bingqiang KANG, Fen LI, Zujian TANG, Hanwen DENG, Hongmei SONG, Junyou GE, Jingyi WANG
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Patent number: 11970506Abstract: Provided herein are bioactive molecule conjugates, preparation methods and use thereof, particularly bioactive molecule conjugates (such as antibody-drug conjugates and small molecule drug conjugates) obtained by improved coupling of a drug and a targeting moiety, as well as their preparation method and use for the treatment of a disease associated with an abnormal cell activity.Type: GrantFiled: December 10, 2018Date of Patent: April 30, 2024Assignee: SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.Inventors: Jiaqiang Cai, Shuai Song, Tongtong Xue, Liang Xiao, Hanwen Deng, Qiang Tian, Guoqing Zhong, Lichun Wang, Jingyi Wang
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Publication number: 20230357259Abstract: The disclosure relates to a bioactive molecule conjugate, preparation methods and use thereof, particularly relates to a novel bioactive molecule conjugate obtained by improving coupling of the drug and the targeting moiety in an ADC or SMDC, as well as its preparation method and use in the manufacture of a medicament for the treatment of a disease associated with an abnormal cell activity.Type: ApplicationFiled: January 17, 2023Publication date: November 9, 2023Inventors: Jiaqiang CAI, Shuai SONG, Tongtong XUE, Liang XIAO, Hanwen DENG, Qiang TIAN, Jing WANG, Dengnian LIU, Liping LIU, Haimin YU, Zhouning YANG, Xu CAO, Guoqing ZHONG, Lichun WANG, Jingyi WANG
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Patent number: 11207420Abstract: Provided is a method for modifying a chimeric antigen receptor-modified T cell (CAR-T cell). The method comprises expressing an SCFV-CDS TM-4-1BB-CD3? molecule in a T cell. The CAR-T cell prepared using the method can specifically recognize and bind to a tumor cell with elevated expression of a ROBO1 protein, and can be used to prevent and treat a corresponding tumor-related disease.Type: GrantFiled: April 12, 2018Date of Patent: December 28, 2021Assignee: SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.Inventors: Jiaqiang Cai, Tongtong Xue, Shuai Song, Jing Wang, Qiang Tian, Liang Xiao, Hanwen Deng, Liping Liu, Zujian Tang, Hong Zeng, Rongrong Long, Hongmei Song, Qiang Zhang, Guoqing Zhong, Dengnian Liu, Haitao Huang, Ruibin Hu, Lichun Wang, Jingyi Wang
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Patent number: 11166954Abstract: The present invention relates to a method for prophylactically treating or treating a viral disease, comprising administering to a subject in need thereof a dihydropyrimidine compound, and the viral diseases include, but are not limited to, Hepatitis A, Hepatitis B, Hepatitis C, influenza, herpes and acquired immunodeficiency syndrome (AIDS).Type: GrantFiled: April 27, 2020Date of Patent: November 9, 2021Assignee: SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.Inventors: Shuai Song, Jiaqiang Cai, Qiang Tian, Hong Zeng, Hongmei Song, Hanwen Deng, Zujian Tang, Xiaofan Duan, Rongrong Long, Yao Liu, Lichun Wang, Jingyi Wang
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Publication number: 20210101906Abstract: The disclosure relates to a bioactive molecule conjugate, preparation methods and use thereof, particularly relates to a novel bioactive molecule conjugate obtained by improving coupling of the drug and the targeting moiety in an ADC or SMDC, as well as its preparation method and use in the manufacture of a medicament for the treatment of a disease associated with an abnormal cell activity.Type: ApplicationFiled: December 10, 2018Publication date: April 8, 2021Applicant: SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.Inventors: Jiaqiang CAI, Shuai SONG, Tongtong XUE, Liang XIAO, Hanwen DENG, Qiang TIAN, Jing WANG, Dengnian LIU, Liping Liu, Haimin YU, Zhouning YANG, Xu CAO, Guoqing ZHONG, Lichun WANG, Jingyi WANG
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Publication number: 20200347075Abstract: The disclosure relates to a bioactive molecule conjugate, preparation methods and use thereof, particularly relates to a novel bioactive molecule conjugate obtained by improving coupling of the drug and the targeting moiety in an ADC or SMDC, as well as its preparation method and use in the manufacture of a medicament for the treatment of a disease associated with an abnormal cell activity.Type: ApplicationFiled: December 10, 2018Publication date: November 5, 2020Applicant: SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.Inventors: Jiaqiang CAI, Shuai SONG, Tongtong XUE, Liang XIAO, Hanwen DENG, Qiang TIAN, Jing WANG, Dengnian LIU, Liping Liu, Haimin YU, Zhouning YANG, Xu CAO, Guoqing ZHONG, Lichun WANG, Jingyi WANG
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Publication number: 20200253971Abstract: The present invention relates to a method for prophylactically treating or treating a viral disease, comprising administering to a subject in need thereof a dihydropyrimidine compound, and the viral diseases include, but are not limited to, Hepatitis A, Hepatitis B, Hepatitis C, influenza, herpes and acquired immunodeficiency syndrome (AIDS).Type: ApplicationFiled: April 27, 2020Publication date: August 13, 2020Applicant: SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.Inventors: Shuai Song, Jiaqiang Cai, Qiang Tian, Hong Zeng, Hongmei Song, Hanwen Deng, Zujian Tang, Xiaofan Duan, Rongrong Long, Yao Liu, Lichun Wang, Jingyi Wang
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Patent number: 10696669Abstract: The present invention relates to a dihydropyrimidine compound having an antiviral activity, a pharmaceutical composition comprising same, a preparation method therefor and the uses thereof in the prevention or treatment of viral diseases including, but not limited to, Hepatitis A, Hepatitis B, Hepatitis C, influenza, herpes and acquired immunodeficiency syndrome (AIDS).Type: GrantFiled: November 9, 2017Date of Patent: June 30, 2020Assignee: SICHUAN KELUN-BIOTECH BIOPHARMACEUTICALS CO., LTD.Inventors: Shuai Song, Jiaqiang Cai, Qiang Tian, Hong Zeng, Hongmei Song, Hanwen Deng, Zujian Tang, Xiaofan Duan, Rongrong Long, Yao Liu, Lichun Wang, Jingyi Wang
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Publication number: 20200179529Abstract: Provided is a method for modifying a chimeric antigen receptor-modified T cell (CAR-T cell). The method comprises expressing an SCFV-CDS TM-4-1BB-CD3? molecule in a T cell. The CAR-T cell prepared using the method can specifically recognize and bind to a tumor cell with elevated expression of a ROBO1 protein, and can be used to prevent and treat a corresponding tumor-related disease.Type: ApplicationFiled: April 12, 2018Publication date: June 11, 2020Applicant: SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.Inventors: Jiaqiang CAI, Tongtong XUE, Shuai SONG, Jing WANG, Qiang TIAN, Liang XIAO, Hanwen DENG, Liping LIU, Zujian TANG, Hong ZENG, Rongrong LONG, Hongmei SONG, Qiang ZHANG, Guoqing ZHONG, Dengnian LIU, Haitao HUANG, Ruibin HU, Lichun WANG, Jingyi WANG
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Publication number: 20190315771Abstract: The present invention relates to novel 2-acylaminothiazole derivatives. The present invention also relates to the preparation method for these novel 2-acylaminothiazole derivatives and intermediates thereof, and a pharmaceutical composition containing these compounds. Moreover, the present invention also relates to these novel 2-acylaminothiazole derivatives and the pharmaceutical composition containing the same for use in treating and/or preventing thrombopoietin receptor mediated diseases.Type: ApplicationFiled: August 31, 2017Publication date: October 17, 2019Applicant: SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.Inventors: Jiaqiang CAI, Nan YU, Hong ZENG, Hongmei SONG, Yan QING, Shuai SONG, Hanwen DENG, Zujian TANG, Xiaofan DUAN, Haitao HUANG, Hong YE, Gang LIU, Lichun WANG, Jingyi WANG
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Publication number: 20190225603Abstract: The present invention relates to a dihydropyrimidine compound having an antiviral activity, a pharmaceutical composition comprising same, a preparation method therefor and the uses thereof in the prevention or treatment of viral diseases including, but not limited to, Hepatitis A, Hepatitis B, Hepatitis C, influenza, herpes and acquired immunodeficiency syndrome (AIDS).Type: ApplicationFiled: November 9, 2017Publication date: July 25, 2019Applicant: SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.Inventors: Shuai SONG, Jiaqiang CAI, Qiang TIAN, Hong ZENG, Hongmei SONG, Hanwen DENG, Zujian TANG, XIAOFAN DUAN, Rongrong LONG, Yao LIU, Lichun WANG, Jingyi WANG
