Patents by Inventor Hao-Chia Chen

Hao-Chia Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-HIV protein, TAP 29, from tricosanthes, DNA coding therefor and therapeutic uses thereof
    Patent number: 5532214
    Abstract: A new protein, termed TAP 29, obtainable from the root tuber of the plant Trichosanthes kirilowii or produced by recombinant means is useful for treating HIV infections or tumors. In treating HIV infections, the protein is administered alone or in conjunction with conventional AIDS therapies. Also provided are processes for purifying the protein, DNA sequences encoding the protein, hosts expressing the protein, recombinant DNA methods for expressing the protein, and antibodies specific for the protein.
    Type: Grant
    Filed: July 14, 1994
    Date of Patent: July 2, 1996
    Assignees: New York University, American Biosciences, Inc., The United States of America as represented by the Department of Health and Human Services
    Inventors: Sylvia Lee-Huang, Philip L. Huang, Hao-chia Chen, Hsiang-fu Kung, Peter Huang, Henry I. Huang, Paul L. Huang
  • Plant protein useful for treating tumors and HIV infection
    Patent number: 5484889
    Abstract: A protein, in particular MAP 30, obtainable from both the fruit and seeds of Momordica charantia or produced by recombinant means useful for treating tumors and HIV infections is disclosed. In treating HIV infections, the protein is administered alone or in conjunction with conventional AIDS therapies. Also provided are processes for purifying the protein, DNA sequences encoding the protein, and recombinant DNA methods for expressing the protein.
    Type: Grant
    Filed: July 21, 1994
    Date of Patent: January 16, 1996
    Assignees: New York University, American Biosciences, Inc., The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Sylvia Lee-Huang, Philip L. Huang, Peter L. Nara, Hao-Chia Chen, Hsiang-fu Kung, Peter Huang, Henry I. Huang, Paul L. Huang
  • Anti-HIV proteins GAP 31, DAP 30 and DAP 32 and therapeutic uses thereof
    Patent number: 5317009
    Abstract: New proteins, termed GAP 31, obtainable from the seeds of Gelonium multiflorum, and DAP 30 and DAP 32, obtainable from the leaves or seeds of Dianthus caryophyllus, or the above proteins produced by recombinant means, are useful for treating HIV infections. In treating HIV infections, the protein is administered alone or in conjunction with other anti-HIV therapeutics. Also provided are processes for purifying the proteins, DNA sequences encoding the proteins, hosts expressing the proteins, recombinant DNA methods for expressing the proteins, and antibodies specific for the proteins.
    Type: Grant
    Filed: August 26, 1991
    Date of Patent: May 31, 1994
    Assignees: New York University, American Biosciences, Inc., National Institutes of Health
    Inventors: Sylvia Lee-Huang, Hsiang-fu Kung, Paul L. Huang, Philip L. Huang, Peter Huang, Henry I. Huang, Hao-chia Chen
  • Antimicrobial magainin modified peptides
    Patent number: 5221732
    Abstract: Peptides which exhibit improved broad spectrum antimicrobial activity are designed and synthesized based on the peptide sequences of magainin or PGS peptides. The modified peptide analogues are synthesized by replacing low helical potential amino acid residues with high helical potential residues and modifying the two termini in order to enhance the amphiphilic structures as well as to prolong antimicrobial activity by lowering their susceptibility to protease degradation. For example, low propensity residues within a strategic region of magainin II, e.g. Ser.sup.8, Gly.sup.13 and Gly.sup.18 are modified with Ala which is known to have high propensity. Amidation of Ser.sup.23, and acylation of Gly.sup.1 with acetyl or beta-alanyl and substitution of Gly.sup.1 with beta-alanine are carried out in order to lower the susceptibility to exopeptidase action.
    Type: Grant
    Filed: December 6, 1988
    Date of Patent: June 22, 1993
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Hao-Chia Chen, Judith H. Brown, John L. Morell, Charng-Ming Huang
  • Dimeric enkephalins
    Patent number: 4468383
    Abstract: The compounds of the invention are symmetrical dimers of enkephalin polypeptides comprising enkephalin polypeptide monomers linked at the C-termini thereof with a difunctional amino bridging group. The compounds are useful as investigative tools for probing the opiate receptor membranes, particularly as radiolabelled ligands for exploring the delta opiate receptor, and also have particular use as narcotic and/or analgesic agents.
    Type: Grant
    Filed: September 29, 1982
    Date of Patent: August 28, 1984
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Service
    Inventors: David Rodbard, Y. Shimohigashi, Hao-Chia Chen, Tommaso Costa