Abstract: Some aspects of this disclosure provide compositions, methods, systems, and kits for controlling the activity and/or improving the specificity of RNA-programmable proteins, such as Cas9. For example, provided are guide RNAs (gRNAs) that are engineered to exist in an “on” or “off” state, which control the binding and, in certain instances, cleavage activity of RNA-programmable proteins (e.g., RNA-programmable endonucleases). By incorporating ligand-responsive self-cleaving catalytic RNAs (aptazymes) into guide RNAs, a set of aptazyme-embedded guide RNAs was developed that enable small molecule-controlled nuclease-mediated genome editing and small molecule-controlled base editing, as well as small molecule-dependent transcriptional activation in mammalian cells.

Abstract: Systems and methods are provided for performing operations including receiving, via a messaging application, a request to scan an image captured by a camera of the user device; determining an attribute of an object depicted in the image; identifying, from a plurality of augmented reality items, an augmented reality item that is associated with the attribute of the object; combining the identified augmented reality item with the image captured by the camera; and displaying, via the messaging application, the image captured by the camera combined with the identified augmented reality item.

Abstract: A laser projector includes a laser source, a first dichroic mirror, a wavelength conversion module, a second dichroic mirror, a first, a second and a third light valves and a beam combiner. The laser source is for providing a blue beam including a first portion and a second portion. The first dichroic mirror is for receiving and allowing the blue beam to penetrate. The wavelength conversion module is for receiving the first portion and emitting a yellow beam to the first dichroic mirror. The second dichroic mirror is for receiving and separating the yellow beam reflected by the first dichroic mirror into a green and a red beam. The first, second and third light valve are for receiving and modulating respectively the second portion of the blue beam, the green beam and the red beam. The beam combiner is for the beams to form a multi-color image.

Abstract: A method for fabricating semiconductor device includes the steps of forming an inter-metal dielectric (IMD) layer on a substrate, forming a trench in the IMD layer, forming a synthetic antiferromagnetic (SAF) layer in the trench, forming a metal layer on the SAF layer, planarizing the metal layer and the SAF layer to form a metal interconnection, and forming a magnetic tunneling junction (MTJ) on the metal interconnection.

Abstract: A storage drive, including: a main module, including: a main printed circuit board (PCB) having a first side positioned opposite to a second side; flash memory components positioned on the main PCB at a first end of the storage drive, a controller module positioned on the main PCB at a second end of the storage drive opposite to the first end; and a capacitor module, including: a module printed circuit board (PCB) having a first side positioned opposite to a second side; a plurality of capacitors positioned on the module PCB on the first side of the module PCB, wherein the capacitor module is coupled to the main module such that the capacitor module is positioned at the first end of the storage drive and the first side of the capacitor module faces the first side of the main module.

Abstract: Semiconductor processing systems and methods are provided in which an amount or concentration of a chemical in a chemical mixture contained in a tank is automatically controlled based on a sensed properties of the chemical mixture. In some embodiments, a semiconductor processing system includes a processing tank that is configured to contain a chemical mixture. A chemical sensor is configured to sense one or more properties of the chemical mixture. The system further includes an electrically controllable valve that is configured to adjust an amount of the first chemical in the chemical mixture based on the sensed one or more properties of the chemical mixture.

Abstract: A semiconductor device includes a substrate having a magnetic random access memory (MRAM) region and a logic region, a first metal interconnection on the MRAM region, a second metal interconnection on the logic region, a stop layer extending from the first metal interconnection to the second metal interconnection, and a magnetic tunneling junction (MTJ) on the first metal interconnection. Preferably, the stop layer on the first metal interconnection and the stop layer on the second metal interconnection have different thicknesses.

Abstract: The present disclosure discloses a magnetic flexible tactile sensor structure based on a folding magnetization method, which comprises a flexible body containing a permanent magnetic material; the flexible body has a negative Poisson's ratio structure, and its set area has undergone folding magnetization treatment. The present disclosure also discloses a sensor composed of the above-mentioned sensing structure. The sensor provided by the present disclosure can be applied in sealed and wireless scenarios. The present disclosure can detect the size and position of force. The flexible sensor has broad prospects in the application of the touch skin of robots. The function between the magnetic field-based sensing magnet and the Hall element is contactless. In some cases where it is difficult to establish isolation of the connection lines, it can also be used as an unfettered tactile sensor.

Abstract: Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for engineering Cas9 and Cas9 variants that have increased activity on target sequences that do not contain the canonical PAM sequence (e.g., NGG). In some embodiments, fusion proteins comprising such Cas9 variants and nucleic acid editing domains, e.g., deaminase domains, are provided.

Abstract: Disclosed is an aliphatic polyisocyanate composition, wherein the molar ratio of an iminooxadiazinedione structure to an isocyanurate structure is 0.01-0.8:1, and the molar ratio of an iminooxadiazinedione structure in a polymer larger than three molecules to the iminooxadiazinedione structure in the composition is 0.2-0.8:1. Provided are a method for preparing the aliphatic polyisocyanate composition, and a coating composition. The aliphatic polyisocyanate composition has both a lower viscosity and a better crosslinking property. The composition can significantly reduce the usage amount of a solvent when used in a coating composition, is more environmentally friendly and also has a better paint film property. The preparation method has a simple process and mild conditions, is easy to operate and control, and is suitable for industrial scale production.

Abstract: Disclosed are a solid form of (E)-3-((R)-4-(((R)-6-(2-chloro-4-fluorophenyl)-5-(methoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholin-2-yl)acrylic acid, a preparation method therefor, a pharmaceutical composition comprising same, and the use thereof in the preparation of drugs for preventing or treating viral diseases.

Abstract: Embodiments disclosed herein are related to implementing a near-real-time stream processing system using the same distributed file system as a batch processing system. A data container and partition files are generated according to a partition window that specifies a time range that controls when data is to be included in the partition files. The data container is scanned to determine if the partition files are within a partition lifetime window that specifies a time range that controls how long the partition files are active for processing. For each partition file within the lifetime window, processing tasks are created based on an amount of data included in the partition files. The data in the partition files is accessed and the processing tasks are performed. Information about the partition files is recorded in a configuration data store.

Abstract: Embodiments disclosed herein are related to implementing a near-real-time stream processing system using the same distributed file system as a batch processing system. A data container and partition files are generated according to a partition window that specifies a time range that controls when data is to be included in the partition files. The data container is scanned to determine if the partition files are within a partition lifetime window that specifies a time range that controls how long the partition files are active for processing. For each partition file within the lifetime window, processing tasks are created based on an amount of data included in the partition files. The data in the partition files is accessed and the processing tasks are performed. Information about the partition files is recorded in a configuration data store.

Abstract: An adaptor for incorporating a function of an Open Compute Project (OCP) mezzanine card into a storage device includes a framework, a baseboard mounted to the framework and arranged to have the Open Compute Project (OCP) mezzanine card mounted thereon, an adapting part on the baseboard, the adapting part including an insertion slot for receiving a first interface of the OCP mezzanine card, and a connector on the baseboard, the connector configured to connect with the storage device, the baseboard including interconnections between the connector and the adapting part to provide for data exchange between the OCP mezzanine card and the storage device.

Abstract: A method of fabricating a substrate having a through via includes: providing a carrier board having a release layer thereon; attaching the substrate onto the carrier board via the release layer; applying a light beam to the substrate to form a first blind hole in the substrate, wherein the first blind hole penetrates a first surface and a second surface of the substrate; performing an enlargement process on the first blind hole to form a second blind hole; forming a through via in the second blind hole; and performing a de-bonding process to release the substrate having a through via from the carrier board.

Abstract: Aspects of the present disclosure involve a system and a method for performing operations comprising: capturing, by a client device implementing a messaging application, an image; receiving, from a server, an identification of an augmented reality experience associated with the image, the server identifying the augmented reality experience by assigning visual words to features of the image and searching a visual search database to identify a plurality of marker images, and the server retrieving the augmented reality experience associated with a given one of the plurality of marker images; automatically, in response to capturing the image, displaying one or more graphical elements of the identified augmented reality experience; and receiving input from the user interacting with the one or more graphical elements.

Abstract: An adjustment method of laser light path includes the steps of: having a laser light path to penetrate through a measuring device to obtain at least two laser focal positions of the laser light path, the at least two laser focal positions forming an arc path; applying a focal position-calculating device to calculate coordinate values of the at least two laser focal positions; based on the arc path and the coordinate values of the at least two laser focal positions to apply the focal position-calculating device to calculate a target laser focal position; and, based on the target laser focal position to apply a light modulator to adjust each of the at least two laser focal positions to the target laser focal position. In addition, an adjustment device of laser light path is also provided.

Abstract: Buttons and other interactive functionality for touchscreen displays of e-book and other electronic media content can be automatically optimized for viewing on client devices, in particular those employing an electrophoretic display. A hardware display driver pushes e-ink material through various predetermined voltage waveforms to consistently accomplish interface effects such as color inversion for a button which is touched on the interface screen. Machine learning schema can assist in determining the appropriate waveforms for interactive elements in the content.

Abstract: The present invention provides a surge protection module which comprises a carrier board and a probe set. The carrier board is used to carry an electronic component. The probe set is disposed on the carrier board and has a plurality of probes and a short-circuit unit. Each probe is used for contacting the electronic component, and the short-circuit unit is selectively moved to a first position or a second position. When the short-circuit unit is moved to the first position, the short-circuit unit simultaneously contacts and shorts the plurality of probes. When the short-circuit unit is moved to the second position, the short-circuit unit is away from at least one of the plurality of probes.

Abstract: A semiconductor apparatus includes a transfer chamber, an annealing station, a robot arm, an edge detector and a trigger device. The transfer chamber is configured to interface with an electroplating apparatus. The robot arm is arranged to transfer a wafer from the transfer chamber to the annealing station. The edge detector, disposed over a predetermined location between the transfer chamber and the annealing station, comprises a first charge-coupled device (CCD) sensor and a second CCD sensor. When the robot arm is carrying the wafer to pass through the predetermined location, the first CCD sensor and the second CCD sensor are located over a first portion and a second portion of the edge bevel removal area respectively, and the trigger device is configured to activate the first CCD sensor and the second CCD sensor to capture an image of the first portion and an image of the second portion respectively.