Abstract: An integrated physiological signal assessing device integrates electrical signal detecting technology and optical detecting technology to design a sensing interface module for simultaneously measuring ECG signals and PPG signals, and utilizes multiple algorithm processing methods to obtain ECG parameters, such as rhythm of a heart, ST segment, and QRS interval, as well as vascular parameters, such as vascular stiffness index (SI), vascular reflection index (RI), pulse wave velocity (PWV), and pulse oxygen saturation (SpO2), so as to simplify the conventional vascular functions measuring devices, easily understand physiological conditions of a subject, and helpfully apply on diagnosis and prevention of cardiovascular diseases.