Abstract: An equipment and application method for sinkage detection and active escape of deep-sea mining vehicle, comprising: the sinkage detection and warning devices and the self-escape equipment. The sinkage detection and warning devices are installed on the left and right sides of each track of the deep-sea mining vehicle, and it monitors the contact conditions between the tracks and the sediment, and the distance from the bottom of the track to the device is measured. The self-escape equipment comprises the active interactive grouting system, which connects to intelligent steering and retractable grouting heads. The intelligent steering and retractable grouting heads are also located on the left and right sides of each track. This invention can detect the complex driving environment of the seafloor automatically and combine the existing grouting technology and materials to achieve active grouting escape in case of excessive sinkage.

Abstract: This invention discloses a model test device and method for curtain grouting and excavation of tunnels in high-temperature, water-rich and weak strata, comprising weak strata simulation system, working condition simulation system, curtain grouting system, and monitoring and data acquisition system. The weak strata simulation system is the main box used to fill the soft soil. The working condition simulation system includes a high geothermal simulation system, a water pressure simulation system with stepwise loading of water pressure and volume, and a three-dimensional confining pressure simulation system with stepwise controllable loading of confining pressure. The invention can realize the whole test process simulation of grouting reinforcement and excavation of tunnels in weak strata effectively under the action of confining pressure and geothermal heat, and it has a positive reference effect on actual soft stratum tunnel curtain grouting and safe excavation.

Abstract: The present disclosure relates to a type of novel lipid compound and a use thereof, and specifically relates to a type of novel lipid compound and to a lipid nanodelivery carrier comprising the compound; the compound has improved biocompatibility, effectively reduces the toxic side effects of nucleic acid drug lipid nanoparticles, increases the variety of ionizable lipid compounds, and provides more choices for the delivery of nucleic acid drugs.

Abstract: The present disclosure provides a grommet including a body, at least one first retaining portion, at least one second retaining portion and at least one operating portion. The body defines a receiving channel and a longitudinal axis, and includes a first axial body portion and a second axial body portion. The first axial body portion includes at least one first body segment and at least one second body segment disposed about the axis and spaced apart. The first retaining portion is provided on a side of the first body segment facing away from the axis. The second retaining portion is provided at an end of the second body segment away from the second axial body portion and extends away from the axis. The operating portion is provided at an end of the first body segment away from the second axial body portion and extends away from the axis.

Abstract: The present disclosure provides an object regulation method, electronic device and a non-transitory computer-readable storage medium. The method includes: obtaining a policy group, where the policy group includes target object information and at least one policy, and the policy includes: a regulation condition and a regulation action that correspond to each other; generating a query task based on the target object information and the regulation condition, and performing the query task to obtain regulation data; and performing the regulation action corresponding to the regulation condition on a target object corresponding to the target object information when the regulation data meets the regulation condition. In this way, after a user configures the policy group, the target object may be intelligently regulated without subsequent human participation, thereby effectively improving regulation efficiency of the target object, and improving regulation accuracy.

Abstract: This invention discloses a model test apparatus and method for shield post-wall grouting and tube sheet uplift under high water pressure conditions, comprising main body box, tension apparatus, shield system, grouting system, ground stress loading system, water injection system, and monitoring system. The main body box comprises the shield shell system and model soil inside. The ground stress loading system and water injection system realize the simulation of the complex underground soil and muddy water environment by applying stress and water pressure to the model soil inside the main box. While the tension apparatus makes the shield shell moving forward, the grouting system injects slurry into the gap between the shield shell and the tube sheet. The integrated model test of visual shield grouting and tube sheet uplift, the real-time multi-physical field responses, and the longitudinal deformation mechanism have been realized and revealed under high water pressure conditions.

Abstract: A synchronous single-liquid grouting slurry, its technology and application for large diameter shield engineering under water-rich, high-pressure and weak soil strata conditions, comprising raw materials: 1050-1200 parts of gold tailing, 420-480 parts of silicate cement clinker, 220-240 parts of fly ash, 45-120 parts of waste clay brick, 65-95 parts of slag, 25-45 parts of limestone tailing, 70-80 parts of steel slag, 30-45 parts of silica fume, 15-22 parts of desulfurized gypsum, and 9-15 parts of quick-setting and early-strength composite additive. The invention controls the d50, d85 and d95 of the material particles as 35-40, 42-48 and 50-55 ?m, respectively. Gold tailing with the particle size of 120-600 ?m being used as the fine aggregate, their volume fractions are 40-60%. The slurry production technique, comprising crushing-sieving-superfine ball milling-homogenization-particle size classification-variable speed mixing being developed.

Abstract: Isolated anti-human B7-H3 antibody includes two heavy chains including a hinge region comprising an amino acid sequence that allows site-specific conjugation of cytotoxic drugs. Each heavy chain includes a human CH1 domain located upstream of and connected to the hinge region. The CH1 domain comprises a cysteine at the position of 142 according to the IMGT numbering scheme. ADCs containing the antibody conjugated with a cytotoxic drug are also provided. Pharmaceutical compositions including the antibody or the ADCs, and methods of treating cancer using the pharmaceutical compositions are also provided.

Abstract: An equipment and application method for sinkage detection and active escape of deep-sea mining vehicle, comprising: the sinkage detection and warning devices and the self-escape equipment. The sinkage detection and warning devices are installed on the left and right sides of each track of the deep-sea mining vehicle, and it monitors the contact conditions between the tracks and the sediment, and the distance from the bottom of the track to the device is measured. The self-escape equipment comprises the active interactive grouting system, which connects to intelligent steering and retractable grouting heads. The intelligent steering and retractable grouting heads are also located on the left and right sides of each track. This invention can detect the complex driving environment of the seafloor automatically and combine the existing grouting technology and materials to achieve active grouting escape in case of excessive sinkage.

Abstract: This invention discloses a model test apparatus and method for shield post-wall grouting and tube sheet uplift under high water pressure conditions, comprising main body box, tension apparatus, shield system, grouting system, ground stress loading system, water injection system, and monitoring system. The main body box comprises the shield shell system and model soil inside. The ground stress loading system and water injection system realize the simulation of the complex underground soil and muddy water environment by applying stress and water pressure to the model soil inside the main box. While the tension apparatus makes the shield shell moving forward, the grouting system injects slurry into the gap between the shield shell and the tube sheet. The integrated model test of visual shield grouting and tube sheet uplift, the real-time multi-physical field responses, and the longitudinal deformation mechanism have been realized and revealed under high water pressure conditions.

Abstract: This invention discloses a model test device and method for curtain grouting and excavation of tunnels in high-temperature, water-rich and weak strata, comprising weak strata simulation system, working condition simulation system, curtain grouting system, and monitoring and data acquisition system. The weak strata simulation system is the main box used to fill the soft soil. The working condition simulation system includes a high geothermal simulation system, a water pressure simulation system with stepwise loading of water pressure and volume, and a three-dimensional confining pressure simulation system with stepwise controllable loading of confining pressure. The invention can realize the whole test process simulation of grouting reinforcement and excavation of tunnels in weak strata effectively under the action of confining pressure and geothermal heat, and it has a positive reference effect on actual soft stratum tunnel curtain grouting and safe excavation.

Abstract: This invention discloses a double-liquid grouting slurry, its technology and application for super large diameter underwater shield engineering under high water pressure condition. The materials of slurry I are: 35-45 parts of cement clinker; 15-25 parts of slag; 24-35 parts of fly ash; 15-25 parts of steel slag; 5-15 parts of bentonite; 4-10 parts of limestone tailing; 0.3-2.0 parts of water reducing agent; 0.5-2.5 parts of cellulose. The materials of slurry II are: 0.2-3.8 parts of short-cut fiber; 96-99 parts of sodium silicate solution; 0.8-4.8 parts of viscous polymers. This invention generates the double-liquid slurry preparation process including crushing-screening-milling-group mixing-grouped mixing at different speeds, the volume ratio of slurry I and II is 1:1-10:1 during grouting, and the slurry is injected into the shield void through the six-point position technology at the shield tail and 3+2+1 segment splicing synchronous grouting techniques.

Abstract: A synchronous single-liquid grouting slurry, its technology and application for large diameter shield engineering under water-rich, high-pressure and weak soil strata conditions, comprising raw materials: 1050-1200 parts of gold tailing, 420-480 parts of silicate cement clinker, 220-240 parts of fly ash, 45-120 parts of waste clay brick, 65-95 parts of slag, 25-45 parts of limestone tailing, 70-80 parts of steel slag, 30-45 parts of silica fume, 15-22 parts of desulfurized gypsum, and 9-15 parts of quick-setting and early-strength composite additive. The invention controls the d50, d85 and d95 of the material particles as 35-40, 42-48 and 50-55 ?m, respectively. Gold tailing with the particle size of 120-600 ?m being used as the fine aggregate, their volume fractions are 40-60%. The slurry production technique, comprising crushing-sieving-superfine ball milling-homogenization-particle size classification-variable speed mixing being developed.

Abstract: The presence of a rheology modifier in a conductive composition of metal coated core particles improves both rheology and conductivity. In preferred embodiments the rheology modifier is selected from the group consisting of fumed silica, carbon nano-tubes, and graphite. In further embodiments the metal coated particles are silver coated glass or copper particles.

Abstract: The present invention is to provide a semiconductor packaging applicable conductive composition using silver coated material flakes as a conductive filler, curable epoxy, acrylate, bismaleimide chemical, or the like or their combination as organic resin, and the method for preparing the same. The composition is capable of showing desired workability as dispensable die attach adhesive with right rang of rheology, viscosity and physical stability in storing, being excellent in reliability of conductivity or corrosion resistance, and reducing the amount of high price silver in composition.