Abstract: Provided are a GLP-1 receptor agonist compound and a composition and use thereof. The compound can be used for treating or preventing GLP-1 receptor-mediated diseases or disorders and related diseases or disorders.

Abstract: A mixed reality system that includes a device and a base station that communicate via a wireless connection The device may include sensors that collect information about the user's environment and about the user. The information collected by the sensors may be transmitted to the base station via the wireless connection. The base station renders frames or slices based at least in part on the sensor information received from the device, encodes the frames or slices, and transmits the compressed frames or slices to the device for decoding and display. The base station may provide more computing power than conventional stand-alone systems, and the wireless connection does not tether the device to the base station as in conventional tethered systems. The system may implement methods and apparatus to maintain a target frame rate through the wireless link and to minimize latency in frame rendering, transmittal, and display.

Abstract: A method includes obtaining first pass-through image data characterized by a first pose. The method includes obtaining respective pixel characterization vectors for pixels in the first pass-through image data. The method includes identifying a feature of an object within the first pass-through image data in accordance with a determination that pixel characterization vectors for the feature satisfy a feature confidence threshold. The method includes displaying the first pass-through image data and an AR display marker that corresponds to the feature. The method includes obtaining second pass-through image data characterized by a second pose. The method includes transforming the AR display marker to a position associated with the second pose in order to track the feature. The method includes displaying the second pass-through image data and maintaining display of the AR display marker that corresponds to the feature of the object based on the transformation.

Abstract: A system and methods for pathfinding in two- and three-dimensional spaces using an automated planning service, wherein an automated planning service uses worker nodes to create and process abstract problem spaces representing pathfinding problems, and master nodes coordinate the results of workers to provide efficient multi-agent-aware pathfinding.

Abstract: A method of designing a passive metasurface system within an environment includes receiving a three-dimensional model of the environment including one or more transmitter locations and one or more target locations, and determining one or more metasurface designs and placements to achieve a given objective. The method may also include computing a received signal strength at the one or more target locations based on the three-dimensional model of the environment, computing the received signal strength at the one or more target locations based on the three-dimensional model of the environment and the one or more metasurface designs and placements, and/or calculating ray traces and/or using machine learning to determine the received signal strength at the one or more target locations on the three-dimensional model of the environment and the one or more metasurface designs and placements.

Abstract: Provided are compositions and methods related to improved mucins, methods of making the improved mucins, and cells and cell cultures that express glycosylated mucins. The compositions and methods provide improved cell cultures, and improved methods of producing co-expressed proteins that are distinct from the mucins.

Abstract: A laminating device laminates a functional foil onto a surface of an optical element. The laminating device includes a holding module, an optical element holder, and a thermal forming module. The holding module has a sleeve-shaped foil holder extending along a central longitudinal axis with an opening at an upper longitudinal end. The upper longitudinal end holds the functional foil and the optical element holder holds an optical element. The foil holder surrounds the optical element holder. The thermal forming module contains an air passage for providing an air flow with controlled temperature and pressure, which is arranged at a lower longitudinal end of the thermal forming module. The holding module and the thermal forming module are arranged along the central longitudinal axis such that the lower longitudinal end of the thermal forming module and the upper longitudinal end of the foil holder are facing each other.

Abstract: A method includes obtaining first pass-through image data characterized by a first pose. The method includes obtaining respective pixel characterization vectors for pixels in the first pass-through image data. The method includes identifying a feature of an object within the first pass-through image data in accordance with a determination that pixel characterization vectors for the feature satisfy a feature confidence threshold. The method includes displaying the first pass-through image data and an AR display marker that corresponds to the feature. The method includes obtaining second pass-through image data characterized by a second pose. The method includes transforming the AR display marker to a position associated with the second pose in order to track the feature. The method includes displaying the second pass-through image data and maintaining display of the AR display marker that corresponds to the feature of the object based on the transformation.

Abstract: A multi-layer low-pass filter is used to filter a first frame of video data representing at least a portion of an environment of an individual. A first layer of the filter has a first filtering resolution setting for a first subset of the first frame, while a second layer of the filter has a second filtering resolution setting for a second subset. The first subset includes a data element positioned along a direction of a gaze of the individual, and the second subset of the frame surrounds the first subset. A result of the filtering is compressed and transmitted via a network to a video processing engine configured to generate a modified visual representation of the environment.

Abstract: A method jointly optimizes a passive metasurface and a multiple input multiple output (MIMO) antenna array to achieve dynamic adaptation and high RSS. The passive metasurface consists of one or more conductive layers and dielectric layers. The metasurface supports dual band communication. For the uplink, the outgoing signals is generated by jointly optimizing antenna array and metasurface design. For the downlink, the designed metasurface is used together with incident-angle-insensitive meta cells to effectively combine arriving signals at the receiving antennas from all incident angles.

Abstract: A constant-temperature water supply system employing a carbon dioxide heat pump includes a primary side loop, a secondary side water supply pipeline, a carbon dioxide heat pump water heater in the primary side loop, and a heat exchanger between the primary side loop and the secondary side water supply pipeline; the temperature of return water is detected and the temperature of a return water tank is detected, so even if the temperature of return water flowing out of a first heat exchange tube fluctuates, the return water can be input at a position in the return water tank having a close temperature, such that water in the return water tank is always in a stably layered state, and therefore allows for constant-temperature water supply.

Abstract: The present disclosure provides a method for sericin removal. Since sodium borohydride has a high hydrogen storage performance, a convenient hydrogen release, and relatively-stable chemical properties, the sodium borohydride in a sodium borohydride aqueous solution reacts with water slowly to release hydrogen. A large number of accumulated hydrogen bubbles pass through silk fibers, and produce an upward pulling force to the sericin on a fiber surface along the silk fibers under the action of inertial force and surface tension, thereby achieving the sericin removal at room temperature. Moreover, the method for sericin removal has a simple process, a complete sericin removal effect, and no damage to the structure of silk fibroin fibers, and can prepare the silk fibroin fibers with high flexibility and bright color.

Abstract: A hot water system with transcritical carbon dioxide single-stage or double-stage compression and a control method therefor is provided. The hot water system includes a first-stage compressor, a first heat exchanger for exchanging heat with cooling water on user side, a second-stage compressor, a second heat exchanger for exchanging heat with the cooling water on user side, a third heat exchanger for exchanging heat between a liquid phase refrigerant and a gas phase refrigerant, an expansion valve, a fourth heat exchanger for exchanging heat with ambient air, a buffer water tank, a first proportional valve, a second proportional valve, a third proportional valve, a fourth proportional valve, a defrosting valve, and a refrigerant circuit bypass valve. The hot water system can switch between the single-stage compression ad the double-stage compression in high-temperature and low-temperature weather, ensuring that the system has good heating capacity and energy efficiency ratio.

Abstract: The present application provides a chain-type roller coating apparatus, including a liquid coating roller and a synchronizing wheel. The synchronizing wheel is provided with a mounting hole. A proximity switch is arranged on an outer side of the synchronizing wheel. The synchronizing wheel is further provided with a trigger element which is configured to be sensed by the proximity switch. The liquid coating roller is assembled with the mounting hole of the synchronizing wheel by a connecting shaft. A shaft main body of the connecting shaft is equipped with a rotation support device configured to support a rotation of the shaft main body. The rotation support device is equipped with a first lifting driving device configured to drive the rotation support device to ascend or descend vertically. A ranging sensor is arranged exactly above the liquid coating roller.

Abstract: A multi-layer low-pass filter is used to filter a first frame of video data representing at least a portion of an environment of an individual. A first layer of the filter has a first filtering resolution setting for a first subset of the first frame, while a second layer of the filter has a second filtering resolution setting for a second subset. The first subset includes a data element positioned along a direction of a gaze of the individual, and the second subset of the frame surrounds the first subset. A result of the filtering is compressed and transmitted via a network to a video processing engine configured to generate a modified visual representation of the environment.

Abstract: Systems within materials handling facilities or retail establishments are programmed to receive images from cameras, process clips of the images to generate sets of features representing product spaces and actors depicted within such images, and to classify the clips as depicting or not depicting a shopping event. The images are dynamically cropped to reduce amounts of data that must be processed to in order to determine whether the images depict shopping events. The images are cropped by calculating a center point based on positions of points on product spaces and detected overlaps of hands and the product spaces. Features of clips determined to depict a shopping event are combined into a sequence and transferred, along with classifications of such clips, to a multi-camera system that generates a shopping hypothesis based on such features.

Abstract: Various implementations disclosed herein include devices, systems, and methods that incorporate enhanced metadata into spatial and/or mixed reality capture environments. For example, a process may include capturing an original video content recording that includes one or more frames depicting a first view provided by a head mounted device (HMD) at one or more instants in time. The process may further generate an adapted video content recording by adapting brightness of the one or more frames of the original video content recording to account for a difference between a first viewing condition associated with the first view and a second viewing condition associated with non-immersive viewing. The process may further generate metadata comprising information associated with the first viewing condition and the metadata may be associated with the adapted video content recording.

Abstract: An internal and external coupling shear resistance locking control system and monitoring method of tunnel surrounding rocks, comprises an internal shear resistance and monitoring system of tunnel surrounding rocks, an external shear resistance and monitoring system of tunnel surrounding rocks, a relative shear displacement monitoring system of the tunnel walls and the roof and floor layers, and an anchor agent installation system; holes are expanded in the anchor cable drilling holes passing through coal-rock interface areas of the coal walls and roof and floor rock layers to form shear misalignment tolerance cavities; monitoring pressure values of measuring bags and liquid discharge in the shear misalignment tolerance cavities to determine shear deformations of the shear misalignment tolerance cavities, monitoring forces on anchor cables, compensating pull rods and shear resistance steel strips, and adjusting the shear resistance of the anchor cable and steel belt through the compensation rod structure.

Abstract: The present disclosure relates to data transmission methods, systems, and apparatuses. In one example method, a first device sends first information of a first data block to a second device. The second device searches, based on the first information, a first index for a second data block similar to the first data block, and sends second information of the second data block to the first device. The first device locally obtains, based on the second information, a reference block that is the same as the second data block, compresses a difference part of the first data block relative to the reference block to obtain first compressed information, and sends the first compressed information to the second device. The second device obtains the first data block based on the first compressed information and the second data block.

Abstract: The present disclosure provides a method for roller-coating a liquid material, including roller-coating the liquid material on a silicon wafer with a liquid coating roller, and controlling a thickness of the liquid material carried on the liquid coating roller with a liquid taking roller, where a liquid retaining structure is provided at two ends of the liquid coating roller and/or two ends of the liquid taking roller, and the liquid retaining structure is configured to prevent the liquid material from flowing out from the two ends of the liquid coating roller and the two ends of the liquid taking roller.