Patents by Inventor Hao Zhuge

Hao Zhuge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SPIRO AROMATIC RING COMPOUND AND USE THEREOF
    Publication number: 20240116949
    Abstract: Provided is a compound of formula I or a pharmaceutically acceptable salt, enantiomer, diastereomer, tautomer, solvate, isotopic substituent, polymorph, prodrug, or metabolite thereof. Also provided is a method for preparing the compound of formula I. The compound of formula I has higher inhibitory activity against SHP2, and thus can be used to prevent or treat a disease related to SHP2.
    Type: Application
    Filed: May 11, 2023
    Publication date: April 11, 2024
    Inventors: Qiangang Zheng, Ming Xu, Qinglong Zeng, Jing Li, Hao Zhuge
  • CRYSTALLINE FORM OF SHP2 INHIBITOR, AND COMPOSITION THEREOF, PREPARATION METHOD THEREFOR, AND USE THEREOF
    Publication number: 20230339975
    Abstract: The present application relates to a compound 1 ((S)-1?-(8-((2-amino-3-chloropyridin-4-yl)thio)imidazo[1,2-c]pyrimidin-5-yl)-5,7-dihydrospiro[cyclopenta[b]pyridine-6,4?-piperidine]-5-amine) represented by formula (I), a novel crystalline form of a hydrate or a solvate thereof, and a pharmaceutical composition comprising the novel crystalline form. The present application further relates to a preparation method for the novel crystalline form and a use of the novel crystalline form.
    Type: Application
    Filed: June 17, 2021
    Publication date: October 26, 2023
    Inventors: Qiangang ZHENG, Hao ZHUGE, Ye ZHAO
  • Spiro aromatic ring compound and application thereof
    Patent number: 11685748
    Abstract: Provided is a compound of formula I or a pharmaceutically acceptable salt, enantiomer, diastereomer, tautomer, solvate, isotopic substituent, polymorph, prodrug, or metabolite thereof. Also provided is a method for preparing the compound of formula I. The compound of formula I has higher inhibitory activity against SHP2, and thus can be used to prevent or treat a disease related to SHP2.
    Type: Grant
    Filed: September 8, 2020
    Date of Patent: June 27, 2023
    Assignee: ETERN BIOPHARMA (SHANGHAI) CO., LTD.
    Inventors: Qiangang Zheng, Ming Xu, Qinglong Zeng, Jing Li, Hao Zhuge
  • SPIRO AROMATIC RING COMPOUND AND APPLICATION THEREOF
    Publication number: 20210238196
    Abstract: Provided are compounds having SHP2 inhibitory activity, preparation methods and use thereof. Specifically, provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, or enantiomers, diastereoisomers, tautomers, solvates, isotope-substituted derivative, polymorphs, prodrugs or metabolites thereof, wherein the groups are as defined in the description. The compounds have high inhibitory acitivity against SHP2, and thus can be used for preventing or treating SHP2-related diseases.
    Type: Application
    Filed: September 8, 2020
    Publication date: August 5, 2021
    Inventors: Qiangang Zheng, Ming Xu, Qinglong Zeng, Jing Li, Hao Zhuge
  • Spiro aromatic ring compound and application thereof
    Patent number: 10844079
    Abstract: Provided is a compound of formula I or a pharmaceutically acceptable salt, enantiomer, diastereomer, tautomer, solvate, isotopic substituent, polymorph, prodrug, or metabolite thereof. Also provided is a method for preparing the compound of formula I. The compound of formula I has higher inhibitory activity against SHP2, and thus can be used to prevent or treat a disease related to SHP2.
    Type: Grant
    Filed: June 22, 2020
    Date of Patent: November 24, 2020
    Assignee: Etern Biopharma (Shanghai) Co., Ltd.
    Inventors: Qiangang Zheng, Ming Xu, Qinglong Zeng, Jing Li, Hao Zhuge
  • SPIRO AROMATIC RING COMPOUND AND APPLICATION THEREOF
    Publication number: 20200317695
    Abstract: Provided is a compound of formula I or a pharmaceutically acceptable salt, enantiomer, diastereomer, tautomer, solvate, isotopic substituent, polymorph, prodrug, or metabolite thereof. Also provided is a method for preparing the compound of formula I. The compound of formula I has higher inhibitory activity against SHP2, and thus can be used to prevent or treat a disease related to SHP2.
    Type: Application
    Filed: June 22, 2020
    Publication date: October 8, 2020
    Inventors: Qiangang Zheng, Ming Xu, Qinglong Zeng, Jing Li, Hao Zhuge