Patents by Inventor Haobing Wang

Haobing Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11844571
    Abstract: The technology described in this document can be embodied in systems and computer-implemented methods for determining a score representing an amount of staining of the cornea. The methods include obtaining a digital image of the cornea stained with a tracer material, receiving a selection of a portion of the image, and processing, by a processing device, the selection to exclude areas with one or more artifacts to define an evaluation area. For each of a plurality of pixels within the evaluation area, a plurality of Cartesian color components are determined and a hue value in a polar coordinate based color space is calculated from the components. An amount of staining of the cornea is then determined as a function of the hue value. The methods also include assigning a score to the evaluation area based on the amount of staining calculated for the plurality of pixels.
    Type: Grant
    Filed: May 6, 2022
    Date of Patent: December 19, 2023
    Assignee: Massachusetts Eye and Ear Infirmary
    Inventors: Reza Dana, Francisco L. Amparo Pulido, Haobing Wang
  • Publication number: 20230110760
    Abstract: The object of the invention is to provide a novel olefin-based molded product useful for various applications. An olefin-based molded product comprising a polymer including a structural unit of at least one polar olefin monomer represented by the general formula (I) CH2=CH—R2—Z(R1)n is provided. In the formula, Z is a hetero atom selected from the group consisting of nitrogen, oxygen, phosphorus, sulfur, and selenium; R1 is a substituted or unsubstituted hydrocarbyl group having 1 to 30 carbon atoms; n is an integer of 1 or 2 depending on the atomic species of Z; and R2 is a substituted or unsubstituted hydrocarbylene group having 2 to 20 carbon atoms.
    Type: Application
    Filed: November 17, 2022
    Publication date: April 13, 2023
    Applicant: RIKEN
    Inventors: Haobing WANG, Yang YANG, Masayoshi NISHIURA, Zhaomin HOU
  • Patent number: 11603417
    Abstract: An object of the present invention is to provide a novel method of producing a nonpolar olefin polymer (e.g., a copolymer of a nonpolar olefin and a polar olefin). The present invention provides a method of producing a polar olefin polymer or copolymer, the method including the polymerization step of polymerizing a polar olefin monomer using, as a catalyst, a polymerization catalyst composition containing: 1) a metallocene complex represented by Formula (I), which contains a central metal M that is scandium (Sc) or yttrium (Y), a ligand Cp* containing a cyclopentadienyl derivative and being bound to the central metal, monoanionic ligands Q1 and Q2, and W neutral Lewis bases L wherein W is an integer of 0 to 3; and 2) an ionic compound composed of a non-coordinating anion and a cation.
    Type: Grant
    Filed: March 14, 2018
    Date of Patent: March 14, 2023
    Assignee: RIKEN
    Inventors: Chunxiang Wang, Haobing Wang, Yang Yang, Masayoshi Nishiura, Zhaomin Hou
  • Patent number: 11535688
    Abstract: The object of the invention is to provide a novel olefin-based molded product useful for various applications. An olefin-based molded product comprising a polymer including a structural unit of at least one polar olefin monomer represented by the general formula (I) CH2?CH—R2—Z(R1)n is provided. In the formula, Z is a hetero atom selected from the group consisting of nitrogen, oxygen, phosphorus, sulfur, and selenium; R1 is a substituted or unsubstituted hydrocarbyl group having 1 to 30 carbon atoms; n is an integer of 1 or 2 depending on the atomic species of Z; and R2 is a substituted or unsubstituted hydrocarbylene group having 2 to 20 carbon atoms.
    Type: Grant
    Filed: March 14, 2019
    Date of Patent: December 27, 2022
    Assignee: RIKEN
    Inventors: Haobing Wang, Yang Yang, Masayoshi Nishiura, Zhaomin Hou
  • Publication number: 20220265137
    Abstract: The technology described in this document can be embodied in systems and computer-implemented methods for determining a score representing an amount of staining of the cornea. The methods include obtaining a digital image of the cornea stained with a tracer material, receiving a selection of a portion of the image, and processing, by a processing device, the selection to exclude areas with one or more artifacts to define an evaluation area. For each of a plurality of pixels within the evaluation area, a plurality of Cartesian color components are determined and a hue value in a polar coordinate based color space is calculated from the components. An amount of staining of the cornea is then determined as a function of the hue value. The methods also include assigning a score to the evaluation area based on the amount of staining calculated for the plurality of pixels.
    Type: Application
    Filed: May 6, 2022
    Publication date: August 25, 2022
    Inventors: Reza Dana, Francisco L. Amparo Pulido, Haobing Wang
  • Patent number: 11350820
    Abstract: The technology described in this document can be embodied in systems and computer-implemented methods for determining a score representing an amount of staining of the cornea. The methods include obtaining a digital image of the cornea stained with a tracer material, receiving a selection of a portion of the image, and processing, by a processing device, the selection to exclude areas with one or more artifacts to define an evaluation area. For each of a plurality of pixels within the evaluation area, a plurality of Cartesian color components are determined and a hue value in a polar coordinate based color space is calculated from the components. An amount of staining of the cornea is then determined as a function of the hue value. The methods also include assigning a score to the evaluation area based on the amount of staining calculated for the plurality of pixels.
    Type: Grant
    Filed: December 2, 2019
    Date of Patent: June 7, 2022
    Assignee: Massachusetts Eye and Ear Infirmary
    Inventors: Reza Dana, Francisco L. Amparo Pulido, Haobing Wang
  • Patent number: 11298018
    Abstract: The present application includes methods, systems and computer readable storage devices for determining a color score for at least a portion of a biological tissue. The subject matter of the application is embodied in a method that includes obtaining a digital image of the biological tissue, and receiving a selection of a portion of the image as an evaluation area. The method also includes determining for each of a plurality of pixels within the evaluation area, a plurality of color components that are based on a Cartesian color space, and determining, from the color components, a hue value in a polar coordinate based color space. The method further includes determining a color value based on the hue value for each of the plurality of pixels, and assigning a color score to the evaluation area based on an average of the color values of the plurality of pixels.
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: April 12, 2022
    Assignee: Massachusetts Eye and Ear Infirmary
    Inventors: Reza Dana, Francisco L. Amparo Pulido, Haobing Wang
  • Publication number: 20210047447
    Abstract: The object of the invention is to provide a novel olefin-based molded product useful for various applications. An olefin-based molded product comprising a polymer including a structural unit of at least one polar olefin monomer represented by the general formula (I) CH2?CH—R2—Z(R1)n is provided. In the formula, Z is a hetero atom selected from the group consisting of nitrogen, oxygen, phosphorus, sulfur, and selenium; R1 is a substituted or unsubstituted hydrocarbyl group having 1 to 30 carbon atoms; n is an integer of 1 or 2 depending on the atomic species of Z; and R2 is a substituted or unsubstituted hydrocarbylene group having 2 to 20 carbon atoms.
    Type: Application
    Filed: March 14, 2019
    Publication date: February 18, 2021
    Applicant: RIKEN
    Inventors: Haobing WANG, Yang YANG, Masayoshi NISHIURA, Zhaomin HOU
  • Publication number: 20200229695
    Abstract: The present application includes methods, systems and computer readable storage devices for determining a color score for at least a portion of a biological tissue. The subject matter of the application is embodied in a method that includes obtaining a digital image of the biological tissue, and receiving a selection of a portion of the image as an evaluation area. The method also includes determining for each of a plurality of pixels within the evaluation area, a plurality of color components that are based on a Cartesian color space, and determining, from the color components, a hue value in a polar coordinate based color space. The method further includes determining a color value based on the hue value for each of the plurality of pixels, and assigning a color score to the evaluation area based on an average of the color values of the plurality of pixels.
    Type: Application
    Filed: December 18, 2019
    Publication date: July 23, 2020
    Inventors: Reza Dana, Francisco L. Amparo Pulido, Haobing Wang
  • Publication number: 20200107715
    Abstract: The technology described in this document can be embodied in systems and computer-implemented methods for determining a score representing an amount of staining of the cornea. The methods include obtaining a digital image of the cornea stained with a tracer material, receiving a selection of a portion of the image, and processing, by a processing device, the selection to exclude areas with one or more artifacts to define an evaluation area. For each of a plurality of pixels within the evaluation area, a plurality of Cartesian color components are determined and a hue value in a polar coordinate based color space is calculated from the components. An amount of staining of the cornea is then determined as a function of the hue value. The methods also include assigning a score to the evaluation area based on the amount of staining calculated for the plurality of pixels.
    Type: Application
    Filed: December 2, 2019
    Publication date: April 9, 2020
    Inventors: Reza Dana, Francisco L. Amparo Pulido, Haobing Wang
  • Patent number: 10548474
    Abstract: The present application includes methods, systems and computer readable storage devices for determining a color score for at least a portion of a biological tissue. The subject matter of the application is embodied in a method that includes obtaining a digital image of the biological tissue, and receiving a selection of a portion of the image as an evaluation area. The method also includes determining for each of a plurality of pixels within the evaluation area, a plurality of color components that are based on a Cartesian color space, and determining, from the color components, a hue value in a polar coordinate based color space. The method further includes determining a color value based on the hue value for each of the plurality of pixels, and assigning a color score to the evaluation area based on an average of the color values of the plurality of pixels.
    Type: Grant
    Filed: December 28, 2017
    Date of Patent: February 4, 2020
    Assignee: Massachusetts Eye & Ear Infirmary
    Inventors: Reza Dana, Francisco L. Amparo Pulido, Haobing Wang
  • Publication number: 20200010581
    Abstract: An object of the present invention is to provide a novel method of producing a nonpolar olefin polymer (e.g., a copolymer of a nonpolar olefin and a polar olefin). The present invention provides a method of producing a polar olefin polymer or copolymer, the method including the polymerization step of polymerizing a polar olefin monomer using, as a catalyst, a polymerization catalyst composition containing: 1) a metallocene complex represented by Formula (I), which contains a central metal M that is scandium (Sc) or yttrium (Y), a ligand Cp* containing a cyclopentadienyl derivative and being bound to the central metal, monoanionic ligands Q1 and Q2, and W neutral Lewis bases L wherein W is an integer of 0 to 3; and 2) an ionic compound composed of a non-coordinating anion and a cation.
    Type: Application
    Filed: March 14, 2018
    Publication date: January 9, 2020
    Applicant: RIKEN
    Inventors: Chunxiang WANG, Haobing WANG, Yang YANG, Masayoshi NISHIURA, Zhaomin HOU
  • Patent number: 10492674
    Abstract: The technology described in this document can be embodied in systems and computer-implemented methods for determining a score representing an amount of staining of the cornea. The methods include obtaining a digital image of the cornea stained with a tracer material, receiving a selection of a portion of the image, and processing, by a processing device, the selection to exclude areas with one or more artifacts to define an evaluation area. For each of a plurality of pixels within the evaluation area, a plurality of Cartesian color components are determined and a hue value in a polar coordinate based color space is calculated from the components. An amount of staining of the cornea is then determined as a function of the hue value. The methods also include assigning a score to the evaluation area based on the amount of staining calculated for the plurality of pixels.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: December 3, 2019
    Assignee: Massachusetts Eye and Ear Infirmary
    Inventors: Reza Dana, Francisco L. Amparo Pulido, Haobing Wang
  • Publication number: 20190021586
    Abstract: The technology described in this document can be embodied in systems and computer-implemented methods for determining a score representing an amount of staining of the cornea. The methods include obtaining a digital image of the cornea stained with a tracer material, receiving a selection of a portion of the image, and processing, by a processing device, the selection to exclude areas with one or more artifacts to define an evaluation area. For each of a plurality of pixels within the evaluation area, a plurality of Cartesian color components are determined and a hue value in a polar coordinate based color space is calculated from the components. An amount of staining of the cornea is then determined as a function of the hue value. The methods also include assigning a score to the evaluation area based on the amount of staining calculated for the plurality of pixels.
    Type: Application
    Filed: June 25, 2018
    Publication date: January 24, 2019
    Inventors: Reza Dana, Francisco L. Amparo Pulido, Haobing Wang
  • Publication number: 20180184898
    Abstract: The present application includes methods, systems and computer readable storage devices for determining a color score for at least a portion of a biological tissue. The subject matter of the application is embodied in a method that includes obtaining a digital image of the biological tissue, and receiving a selection of a portion of the image as an evaluation area. The method also includes determining for each of a plurality of pixels within the evaluation area, a plurality of color components that are based on a Cartesian color space, and determining, from the color components, a hue value in a polar coordinate based color space. The method further includes determining a color value based on the hue value for each of the plurality of pixels, and assigning a color score to the evaluation area based on an average of the color values of the plurality of pixels.
    Type: Application
    Filed: December 28, 2017
    Publication date: July 5, 2018
    Inventors: Reza Dana, Francisco L. Amparo Pulido, Haobing Wang
  • Patent number: 10004395
    Abstract: The technology described in this document can be embodied in systems and computer-implemented methods for determining a score representing an amount of staining of the cornea. The methods include obtaining a digital image of the cornea stained with a tracer material, receiving a selection of a portion of the image, and processing, by a processing device, the selection to exclude areas with one or more artifacts to define an evaluation area. For each of a plurality of pixels within the evaluation area, a plurality of Cartesian color components are determined and a hue value in a polar coordinate based color space is calculated from the components. An amount of staining of the cornea is then determined as a function of the hue value. The methods also include assigning a score to the evaluation area based on the amount of staining calculated for the plurality of pixels.
    Type: Grant
    Filed: May 1, 2015
    Date of Patent: June 26, 2018
    Assignee: Massachusetts Eye and Ear Infirmary
    Inventors: Reza Dana, Francisco L. Amparo Pulido, Haobing Wang
  • Patent number: 9854970
    Abstract: The present application includes methods, systems and computer readable storage devices for determining a color score for at least a portion of a biological tissue. The subject matter of the application is embodied in a method that includes obtaining a digital image of the biological tissue, and receiving a selection of a portion of the image as an evaluation area. The method also includes determining for each of a plurality of pixels within the evaluation area, a plurality of color components that are based on a Cartesian color space, and determining, from the color components, a hue value in a polar coordinate based color space. The method further includes determining a color value based on the hue value for each of the plurality of pixels, and assigning a color score to the evaluation area based on an average of the color values of the plurality of pixels.
    Type: Grant
    Filed: February 21, 2013
    Date of Patent: January 2, 2018
    Assignee: Massachusetts Eye & Ear Infirmary
    Inventors: Reza Dana, Francisco L. Amparo Pulido, Haobing Wang
  • Publication number: 20170055822
    Abstract: The technology described in this document can be embodied in systems and computer-implemented methods for determining a score representing an amount of staining of the cornea. The methods include obtaining a digital image of the cornea stained with a tracer material, receiving a selection of a portion of the image, and processing, by a processing device, the selection to exclude areas with one or more artifacts to define an evaluation area. For each of a plurality of pixels within the evaluation area, a plurality of Cartesian color components are determined and a hue value in a polar coordinate based color space is calculated from the components. An amount of staining of the cornea is then determined as a function of the hue value. The methods also include assigning a score to the evaluation area based on the amount of staining calculated for the plurality of pixels.
    Type: Application
    Filed: May 1, 2015
    Publication date: March 2, 2017
    Inventors: Reza Dana, Francisco L. Amparo Pulido, Haobing Wang