Patents by Inventor Haobing Wang
Haobing Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11844571Abstract: The technology described in this document can be embodied in systems and computer-implemented methods for determining a score representing an amount of staining of the cornea. The methods include obtaining a digital image of the cornea stained with a tracer material, receiving a selection of a portion of the image, and processing, by a processing device, the selection to exclude areas with one or more artifacts to define an evaluation area. For each of a plurality of pixels within the evaluation area, a plurality of Cartesian color components are determined and a hue value in a polar coordinate based color space is calculated from the components. An amount of staining of the cornea is then determined as a function of the hue value. The methods also include assigning a score to the evaluation area based on the amount of staining calculated for the plurality of pixels.Type: GrantFiled: May 6, 2022Date of Patent: December 19, 2023Assignee: Massachusetts Eye and Ear InfirmaryInventors: Reza Dana, Francisco L. Amparo Pulido, Haobing Wang
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Publication number: 20230110760Abstract: The object of the invention is to provide a novel olefin-based molded product useful for various applications. An olefin-based molded product comprising a polymer including a structural unit of at least one polar olefin monomer represented by the general formula (I) CH2=CH—R2—Z(R1)n is provided. In the formula, Z is a hetero atom selected from the group consisting of nitrogen, oxygen, phosphorus, sulfur, and selenium; R1 is a substituted or unsubstituted hydrocarbyl group having 1 to 30 carbon atoms; n is an integer of 1 or 2 depending on the atomic species of Z; and R2 is a substituted or unsubstituted hydrocarbylene group having 2 to 20 carbon atoms.Type: ApplicationFiled: November 17, 2022Publication date: April 13, 2023Applicant: RIKENInventors: Haobing WANG, Yang YANG, Masayoshi NISHIURA, Zhaomin HOU
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Patent number: 11603417Abstract: An object of the present invention is to provide a novel method of producing a nonpolar olefin polymer (e.g., a copolymer of a nonpolar olefin and a polar olefin). The present invention provides a method of producing a polar olefin polymer or copolymer, the method including the polymerization step of polymerizing a polar olefin monomer using, as a catalyst, a polymerization catalyst composition containing: 1) a metallocene complex represented by Formula (I), which contains a central metal M that is scandium (Sc) or yttrium (Y), a ligand Cp* containing a cyclopentadienyl derivative and being bound to the central metal, monoanionic ligands Q1 and Q2, and W neutral Lewis bases L wherein W is an integer of 0 to 3; and 2) an ionic compound composed of a non-coordinating anion and a cation.Type: GrantFiled: March 14, 2018Date of Patent: March 14, 2023Assignee: RIKENInventors: Chunxiang Wang, Haobing Wang, Yang Yang, Masayoshi Nishiura, Zhaomin Hou
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Patent number: 11535688Abstract: The object of the invention is to provide a novel olefin-based molded product useful for various applications. An olefin-based molded product comprising a polymer including a structural unit of at least one polar olefin monomer represented by the general formula (I) CH2?CH—R2—Z(R1)n is provided. In the formula, Z is a hetero atom selected from the group consisting of nitrogen, oxygen, phosphorus, sulfur, and selenium; R1 is a substituted or unsubstituted hydrocarbyl group having 1 to 30 carbon atoms; n is an integer of 1 or 2 depending on the atomic species of Z; and R2 is a substituted or unsubstituted hydrocarbylene group having 2 to 20 carbon atoms.Type: GrantFiled: March 14, 2019Date of Patent: December 27, 2022Assignee: RIKENInventors: Haobing Wang, Yang Yang, Masayoshi Nishiura, Zhaomin Hou
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Publication number: 20220265137Abstract: The technology described in this document can be embodied in systems and computer-implemented methods for determining a score representing an amount of staining of the cornea. The methods include obtaining a digital image of the cornea stained with a tracer material, receiving a selection of a portion of the image, and processing, by a processing device, the selection to exclude areas with one or more artifacts to define an evaluation area. For each of a plurality of pixels within the evaluation area, a plurality of Cartesian color components are determined and a hue value in a polar coordinate based color space is calculated from the components. An amount of staining of the cornea is then determined as a function of the hue value. The methods also include assigning a score to the evaluation area based on the amount of staining calculated for the plurality of pixels.Type: ApplicationFiled: May 6, 2022Publication date: August 25, 2022Inventors: Reza Dana, Francisco L. Amparo Pulido, Haobing Wang
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Patent number: 11350820Abstract: The technology described in this document can be embodied in systems and computer-implemented methods for determining a score representing an amount of staining of the cornea. The methods include obtaining a digital image of the cornea stained with a tracer material, receiving a selection of a portion of the image, and processing, by a processing device, the selection to exclude areas with one or more artifacts to define an evaluation area. For each of a plurality of pixels within the evaluation area, a plurality of Cartesian color components are determined and a hue value in a polar coordinate based color space is calculated from the components. An amount of staining of the cornea is then determined as a function of the hue value. The methods also include assigning a score to the evaluation area based on the amount of staining calculated for the plurality of pixels.Type: GrantFiled: December 2, 2019Date of Patent: June 7, 2022Assignee: Massachusetts Eye and Ear InfirmaryInventors: Reza Dana, Francisco L. Amparo Pulido, Haobing Wang
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Patent number: 11298018Abstract: The present application includes methods, systems and computer readable storage devices for determining a color score for at least a portion of a biological tissue. The subject matter of the application is embodied in a method that includes obtaining a digital image of the biological tissue, and receiving a selection of a portion of the image as an evaluation area. The method also includes determining for each of a plurality of pixels within the evaluation area, a plurality of color components that are based on a Cartesian color space, and determining, from the color components, a hue value in a polar coordinate based color space. The method further includes determining a color value based on the hue value for each of the plurality of pixels, and assigning a color score to the evaluation area based on an average of the color values of the plurality of pixels.Type: GrantFiled: December 18, 2019Date of Patent: April 12, 2022Assignee: Massachusetts Eye and Ear InfirmaryInventors: Reza Dana, Francisco L. Amparo Pulido, Haobing Wang
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Publication number: 20210047447Abstract: The object of the invention is to provide a novel olefin-based molded product useful for various applications. An olefin-based molded product comprising a polymer including a structural unit of at least one polar olefin monomer represented by the general formula (I) CH2?CH—R2—Z(R1)n is provided. In the formula, Z is a hetero atom selected from the group consisting of nitrogen, oxygen, phosphorus, sulfur, and selenium; R1 is a substituted or unsubstituted hydrocarbyl group having 1 to 30 carbon atoms; n is an integer of 1 or 2 depending on the atomic species of Z; and R2 is a substituted or unsubstituted hydrocarbylene group having 2 to 20 carbon atoms.Type: ApplicationFiled: March 14, 2019Publication date: February 18, 2021Applicant: RIKENInventors: Haobing WANG, Yang YANG, Masayoshi NISHIURA, Zhaomin HOU
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Publication number: 20200229695Abstract: The present application includes methods, systems and computer readable storage devices for determining a color score for at least a portion of a biological tissue. The subject matter of the application is embodied in a method that includes obtaining a digital image of the biological tissue, and receiving a selection of a portion of the image as an evaluation area. The method also includes determining for each of a plurality of pixels within the evaluation area, a plurality of color components that are based on a Cartesian color space, and determining, from the color components, a hue value in a polar coordinate based color space. The method further includes determining a color value based on the hue value for each of the plurality of pixels, and assigning a color score to the evaluation area based on an average of the color values of the plurality of pixels.Type: ApplicationFiled: December 18, 2019Publication date: July 23, 2020Inventors: Reza Dana, Francisco L. Amparo Pulido, Haobing Wang
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Publication number: 20200107715Abstract: The technology described in this document can be embodied in systems and computer-implemented methods for determining a score representing an amount of staining of the cornea. The methods include obtaining a digital image of the cornea stained with a tracer material, receiving a selection of a portion of the image, and processing, by a processing device, the selection to exclude areas with one or more artifacts to define an evaluation area. For each of a plurality of pixels within the evaluation area, a plurality of Cartesian color components are determined and a hue value in a polar coordinate based color space is calculated from the components. An amount of staining of the cornea is then determined as a function of the hue value. The methods also include assigning a score to the evaluation area based on the amount of staining calculated for the plurality of pixels.Type: ApplicationFiled: December 2, 2019Publication date: April 9, 2020Inventors: Reza Dana, Francisco L. Amparo Pulido, Haobing Wang
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Patent number: 10548474Abstract: The present application includes methods, systems and computer readable storage devices for determining a color score for at least a portion of a biological tissue. The subject matter of the application is embodied in a method that includes obtaining a digital image of the biological tissue, and receiving a selection of a portion of the image as an evaluation area. The method also includes determining for each of a plurality of pixels within the evaluation area, a plurality of color components that are based on a Cartesian color space, and determining, from the color components, a hue value in a polar coordinate based color space. The method further includes determining a color value based on the hue value for each of the plurality of pixels, and assigning a color score to the evaluation area based on an average of the color values of the plurality of pixels.Type: GrantFiled: December 28, 2017Date of Patent: February 4, 2020Assignee: Massachusetts Eye & Ear InfirmaryInventors: Reza Dana, Francisco L. Amparo Pulido, Haobing Wang
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Publication number: 20200010581Abstract: An object of the present invention is to provide a novel method of producing a nonpolar olefin polymer (e.g., a copolymer of a nonpolar olefin and a polar olefin). The present invention provides a method of producing a polar olefin polymer or copolymer, the method including the polymerization step of polymerizing a polar olefin monomer using, as a catalyst, a polymerization catalyst composition containing: 1) a metallocene complex represented by Formula (I), which contains a central metal M that is scandium (Sc) or yttrium (Y), a ligand Cp* containing a cyclopentadienyl derivative and being bound to the central metal, monoanionic ligands Q1 and Q2, and W neutral Lewis bases L wherein W is an integer of 0 to 3; and 2) an ionic compound composed of a non-coordinating anion and a cation.Type: ApplicationFiled: March 14, 2018Publication date: January 9, 2020Applicant: RIKENInventors: Chunxiang WANG, Haobing WANG, Yang YANG, Masayoshi NISHIURA, Zhaomin HOU
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Patent number: 10492674Abstract: The technology described in this document can be embodied in systems and computer-implemented methods for determining a score representing an amount of staining of the cornea. The methods include obtaining a digital image of the cornea stained with a tracer material, receiving a selection of a portion of the image, and processing, by a processing device, the selection to exclude areas with one or more artifacts to define an evaluation area. For each of a plurality of pixels within the evaluation area, a plurality of Cartesian color components are determined and a hue value in a polar coordinate based color space is calculated from the components. An amount of staining of the cornea is then determined as a function of the hue value. The methods also include assigning a score to the evaluation area based on the amount of staining calculated for the plurality of pixels.Type: GrantFiled: June 25, 2018Date of Patent: December 3, 2019Assignee: Massachusetts Eye and Ear InfirmaryInventors: Reza Dana, Francisco L. Amparo Pulido, Haobing Wang
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Publication number: 20190021586Abstract: The technology described in this document can be embodied in systems and computer-implemented methods for determining a score representing an amount of staining of the cornea. The methods include obtaining a digital image of the cornea stained with a tracer material, receiving a selection of a portion of the image, and processing, by a processing device, the selection to exclude areas with one or more artifacts to define an evaluation area. For each of a plurality of pixels within the evaluation area, a plurality of Cartesian color components are determined and a hue value in a polar coordinate based color space is calculated from the components. An amount of staining of the cornea is then determined as a function of the hue value. The methods also include assigning a score to the evaluation area based on the amount of staining calculated for the plurality of pixels.Type: ApplicationFiled: June 25, 2018Publication date: January 24, 2019Inventors: Reza Dana, Francisco L. Amparo Pulido, Haobing Wang
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Publication number: 20180184898Abstract: The present application includes methods, systems and computer readable storage devices for determining a color score for at least a portion of a biological tissue. The subject matter of the application is embodied in a method that includes obtaining a digital image of the biological tissue, and receiving a selection of a portion of the image as an evaluation area. The method also includes determining for each of a plurality of pixels within the evaluation area, a plurality of color components that are based on a Cartesian color space, and determining, from the color components, a hue value in a polar coordinate based color space. The method further includes determining a color value based on the hue value for each of the plurality of pixels, and assigning a color score to the evaluation area based on an average of the color values of the plurality of pixels.Type: ApplicationFiled: December 28, 2017Publication date: July 5, 2018Inventors: Reza Dana, Francisco L. Amparo Pulido, Haobing Wang
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Patent number: 10004395Abstract: The technology described in this document can be embodied in systems and computer-implemented methods for determining a score representing an amount of staining of the cornea. The methods include obtaining a digital image of the cornea stained with a tracer material, receiving a selection of a portion of the image, and processing, by a processing device, the selection to exclude areas with one or more artifacts to define an evaluation area. For each of a plurality of pixels within the evaluation area, a plurality of Cartesian color components are determined and a hue value in a polar coordinate based color space is calculated from the components. An amount of staining of the cornea is then determined as a function of the hue value. The methods also include assigning a score to the evaluation area based on the amount of staining calculated for the plurality of pixels.Type: GrantFiled: May 1, 2015Date of Patent: June 26, 2018Assignee: Massachusetts Eye and Ear InfirmaryInventors: Reza Dana, Francisco L. Amparo Pulido, Haobing Wang
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Patent number: 9854970Abstract: The present application includes methods, systems and computer readable storage devices for determining a color score for at least a portion of a biological tissue. The subject matter of the application is embodied in a method that includes obtaining a digital image of the biological tissue, and receiving a selection of a portion of the image as an evaluation area. The method also includes determining for each of a plurality of pixels within the evaluation area, a plurality of color components that are based on a Cartesian color space, and determining, from the color components, a hue value in a polar coordinate based color space. The method further includes determining a color value based on the hue value for each of the plurality of pixels, and assigning a color score to the evaluation area based on an average of the color values of the plurality of pixels.Type: GrantFiled: February 21, 2013Date of Patent: January 2, 2018Assignee: Massachusetts Eye & Ear InfirmaryInventors: Reza Dana, Francisco L. Amparo Pulido, Haobing Wang
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Publication number: 20170055822Abstract: The technology described in this document can be embodied in systems and computer-implemented methods for determining a score representing an amount of staining of the cornea. The methods include obtaining a digital image of the cornea stained with a tracer material, receiving a selection of a portion of the image, and processing, by a processing device, the selection to exclude areas with one or more artifacts to define an evaluation area. For each of a plurality of pixels within the evaluation area, a plurality of Cartesian color components are determined and a hue value in a polar coordinate based color space is calculated from the components. An amount of staining of the cornea is then determined as a function of the hue value. The methods also include assigning a score to the evaluation area based on the amount of staining calculated for the plurality of pixels.Type: ApplicationFiled: May 1, 2015Publication date: March 2, 2017Inventors: Reza Dana, Francisco L. Amparo Pulido, Haobing Wang