Abstract: The disclosure provides compositions comprising an inhibitory nucleic acid targeting IncExACTI, and methods of use thereof to improve cardiac function in a subject in need thereof. Specifically, the disclosure provides a cardiac long noncoding RNA (IncRNA), referred as IncExACT 1 (SEQ ID NO: 1), and inhibitory nucleic acids targeting IncExACT 1 for reducing expression of IncExACT 1 and/or Dachsous cadherin-related 2 (DCHS2) in a cell, e.g., a cell in a subject for improving cardiac function in a subject, wherein the subject has pathological cardiac hypertrophy and/or heart failure.

Abstract: A porous-structure device includes a semi-submersible platform consisting of four columns, two pontoons, two horizontal supports and a deck. Fillets on middle portions of the columns have a square section, a radius of the fillets, close to the deck and the pontoons, of the columns is gradually decreased to 0, a porous device is disposed outside each column and is formed by combining and connecting four single components, and each single component is formed by combining and connecting a plurality of porous laminated plates and a plurality of connecting pieces. The parameters, such as the pore type, porosity, number of layers, interlayer spacing and installation height, of the porous laminated plates are set according to the wave characteristics in different sea areas.

Abstract: A porous-structure device includes a semi-submersible platform consisting of four columns, two pontoons, two horizontal supports and a deck. Fillets on middle portions of the columns have a square section, a radius of the fillets, close to the deck and the pontoons, of the columns is gradually decreased to 0, a porous device is disposed outside each column and is formed by combining and connecting four single components, and each single component is formed by combining and connecting a plurality of porous laminated plates and a plurality of connecting pieces. The parameters, such as the pore type, porosity, number of layers, interlayer spacing and installation height, of the porous laminated plates are set according to the wave characteristics in different sea areas.

Abstract: A computer system for processing of data related to a permanent life insurance policy includes a data storage device storing data indicative of a policy owner, an insured under the policy, and a death benefit amount, payable under the policy to a beneficiary upon death of the insured, and a processor in communication with the data storage device. A withdrawal benefit providing periodic payments to the owner, each payment reducing the amount of the death benefit until reaching a residual death benefit amount, is available on owner request, at a minimum age of the insured, on meeting a condition related to a likelihood of policy lapse prior to death of the insured. The processor is configured to determine whether premium payments in accordance with a schedule will cause the condition to be met.