Abstract: An apparatus for imaging a target and a process of making the apparatus are provided. The apparatus includes a housing and a distal portion. The distal portion includes an acoustic subarray on a first substrate configured to transmit acoustic signals toward the target. The distal portion includes an optical subarray on a second substrate, configured to detect acoustic signals from the target. The distal portion includes an input/output (I/O) region including one or more optical I/O channels. The one or more optical I/O channels is configured to bend optical signals between the optical subarray and the one or more optical I/O channels.

Abstract: A system and method for imaging biological material is disclosed. The imaging system may comprise: a multi-well assay plate having a plurality of wells, each well of the plurality of wells defining a cavity that is configured to hold a biological material; an imaging module having a plurality of transducers; and a processor coupled to the imaging module. The processor may be configured to: activate the plurality of transducers to emit energy within the plurality of wells to stimulate the biological material, and generate an image of or analyze the biological material within each well. The method may comprise: adding a thin layer of acoustic coupling material; inserting the microwell plate into a support frame of an enclosure; mechanically translating the support frame; interrogating each of the wells of the microwell plate with ultrasound; and outputting results of the interrogation to an output device.