Patents by Inventor Haode Chen

Haode Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240302386
    Abstract: The present invention is directed to an immunoassay method for detecting an analyte in a liquid sample; and provides accuracy and reproducibility for both high concentration and low concentration samples. The method uses both fluorescence marker and chemiluminescence marker, and reads both fluorescence signal and chemiluminescence signal. The analyte concentration is determined based on either a calibration curve for the fluorescence signal, or a calibration curve chemiluminescence signal, using a pre-established analyte concentration value.
    Type: Application
    Filed: December 21, 2021
    Publication date: September 12, 2024
    Inventors: Haode Chen, Heng Wu, Hong Tan, Robert F. Zuk
  • Publication number: 20240272153
    Abstract: The present invention is directed biochemical assay methods with regenerated substrate surface for immunoassay reactions. The methods clean a ceramic or glass substrate surface with atmospheric gas plasma and then coat the cleaned surface directly (without further modification of the cleaned surface) with a hapten-polymer conjugate, a protein, or an anti-non-human IgG antibody as a first layer on the substrate surface for subsequence assay reactions. After the completion of each cycle of reactions, the substrate is cleaned by the same plasma cleaning procedure, to elute the organic molecules formed on the substrate surface and to regenerate the substrate for another cycle of immunoassay reactions. The regeneration protocols can be repeated 1-10 times and maintains acceptable assay performance.
    Type: Application
    Filed: April 5, 2024
    Publication date: August 15, 2024
    Inventors: Haode Chen, Robert F. Zuk
  • Publication number: 20240082836
    Abstract: Introduced here are rotors that can be placed inside of microplate wells that include liquid samples. Each rotor can be comprised of a ferromagnetic material. Accordingly, when a rotor is subjected to an external rotational magnetic field, the rotor spins and agitates the liquid sample inside the corresponding well. The spin speed may be adjusted by changing the rotation speed, direction, and/or orientation of the external rotational magnetic field. The rotor typically includes a central cavity within which a probe can be suspended during the biochemical test.
    Type: Application
    Filed: November 22, 2023
    Publication date: March 14, 2024
    Inventors: Hong Tan, Haode Chen, Genqian Li
  • Publication number: 20230104035
    Abstract: The present invention is directed to a method of measuring the dissociation rate of the binding of an antibody to an antigen. The method has two phases: a first phase of binding and a second phase of dissociation. The first phase of the assay has a probe coated with an antigen, or protein G, or an anti-human IgG Fc antibody. The probe is immersed in a sample solution containing an antibody, followed by a wash sequence, then the probe is transferred to a reagent with a biotinylated antigen. After an incubation, the antibody bound on the probe binds to the biotinylated antigen to form an immune complex. Fluorescent signal is produced by immersing the probe in a reagent having a fluorescent tagged streptavidin. The last step of the first phase is a measurement of fluorescent on the probe tip.
    Type: Application
    Filed: December 5, 2022
    Publication date: April 6, 2023
    Inventors: Robert F. Zuk, Mohsen Karbaschi, Heng Wu, Haode Chen
  • Publication number: 20210041428
    Abstract: The present invention is directed to methods for increasing sensitivities of immunoassays. The invention utilizes an acid elution condition that preferentially elute specifically bound immune complexes over non-specifically bound complexes from a solid phase, and designs immunoassay protocols that improve the ratio of specific binding to non-specific binding and thereby improving assay sensitivity. The protocol determines the signal of the labeled immunocomplexes eluted from a solid phase.
    Type: Application
    Filed: October 13, 2020
    Publication date: February 11, 2021
    Inventors: Robert F. Zuk, Hong Tan, Qing Xia, Pu Li, Haode Chen, Heng Wu
  • Patent number: 10809251
    Abstract: The present invention is directed to methods for increasing sensitivities of immunoassays. The invention utilizes an acid elution condition that preferentially elute specifically bound immune complexes over non-specifically bound complexes from a solid phase, and designs immunoassay protocols that improve the ratio of specific binding to non-specific binding and thereby improving assay sensitivity. The protocol determines the signal of the labeled immunocomplexes eluted from a solid phase.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: October 20, 2020
    Assignee: ACCESS MEDICAL SYSTEMS, LTD.
    Inventors: Robert F. Zuk, Hong Tan, Qing Xia, Pu Li, Haode Chen, Heng Wu
  • Publication number: 20200197887
    Abstract: Introduced here are rotors that can be placed inside of microplate wells that include liquid samples. Each rotor can be comprised of a ferromagnetic material. Accordingly, when a rotor is subjected to an external rotational magnetic field, the rotor spins and agitates the liquid sample inside the corresponding well. The spin speed may be adjusted by changing the rotation speed, direction, and/or orientation of the external rotational magnetic field. The rotor typically includes a central cavity within which a probe can be suspended during the biochemical test.
    Type: Application
    Filed: March 5, 2020
    Publication date: June 25, 2020
    Inventors: Hong TAN, Haode CHEN, Genqian LI
  • Publication number: 20180180606
    Abstract: The present invention is directed to methods for increasing sensitivities of immunoassays. The invention utilizes an acid elution condition that preferentially elute specifically bound immune complexes over non-specifically bound complexes from a solid phase, and designs immunoassay protocols that improve the ratio of specific binding to non-specific binding and thereby improving assay sensitivity. The protocol determines the signal of the labeled immunocomplexes eluted from a solid phase.
    Type: Application
    Filed: February 23, 2018
    Publication date: June 28, 2018
    Inventors: Robert F. Zuk, Hong Tan, Qing Xia, Pu Li, Haode Chen, Heng Wu