Patents by Inventor Haofan Wang

Haofan Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Red fluorescent aldehyde dehydrogenase (ALDH) substrate
    Patent number: 10156521
    Abstract: A detectable substrate for aldehyde dehydrogenase (ALDH) can be used for selecting cells that express ALDH. The detectable substrate can have a fluorescent moiety that has an excitation wavelength, an emission wavelength, or both, that does not overlap with the excitation wavelength, emission wavelength, or both, of green fluorescent protein.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: December 18, 2018
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Martin G. Pomper, Haofan Wang, Il Minn, Steven D. Leach, Ronnie C. Mease
  • Synthesis and application of novel imaging agents conjugated to DPA 713 analogs for imaging inflammation
    Patent number: 9498546
    Abstract: The present invention provides analog compounds of DPA-713 which specifically bind the translocator protein (TSPO), which is upregulated in activated leukocytes, some malignant tumors and tissues involved in steroid biogenesis. These compounds are linked via a linking moiety to a variety of imaging agents, including, for example, near infra-red dyes. The compounds of the present invention are useful for both pre-clinical near-IR fluorescence imaging (NIRF) and use in optically-guided interventions including NIRF endoscopy. Methods of use in diagnosis and treatment of TSPO related disease are also provided.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: November 22, 2016
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Martin Gilbert Pomper, Haofan Wang, Catherine Anne Foss
  • RADIOACTIVE SUBSTRATES FOR ALDEHYDE DEHYDROGENASE
    Publication number: 20160008493
    Abstract: A detectable substrate for aldehyde dehydrogenase (ALDH) can include a radiolabel. When acted upon by ALDH in an ALDH-expressing cell, e.g., cancer cells, the radiolabeled substrate accumulates in the ALDH-expressing cell. ALDH-expressing cells can be distinguished by the accumulated radioactivity. When combined with suitable imaging technique, the detectable substrate can be used for in vivo imaging of cancer cells.
    Type: Application
    Filed: March 17, 2014
    Publication date: January 14, 2016
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: MARTIN C. POMPER, HAOFAN WANG, IL MINN, RONNIE C. MEASE
  • TSPO-targeting compounds and uses thereof
    Patent number: 9233178
    Abstract: Translocator protein (TSPO) targeting compounds are described. Methods of making the compounds, and uses of the compounds for imaging are also described.
    Type: Grant
    Filed: July 14, 2014
    Date of Patent: January 12, 2016
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Martin G. Pomper, Haofan Wang, Tomas R. Guilarte
  • RED FLUORESCENT ALDEHYDE DEHYDROGENASE (ALDH) SUBSTRATE
    Publication number: 20150369738
    Abstract: A detectable substrate for aldehyde dehydrogenase (ALDH) can be used for selecting cells that express ALDH. The detectable substrate can have a fluorescent moiety that has an excitation wavelength, an emission wavelength, or both, that does not overlap with the excitation wavelength, emission wavelength, or both, of green fluorescent protein.
    Type: Application
    Filed: February 21, 2014
    Publication date: December 24, 2015
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: MARTIN G. POMPER, HAOFAN WANG, IL MINN, STEVEN D. LEACH, RONNIE C. MEASE
  • SYNTHESIS AND APPLICATION OF NOVEL IMAGING AGENTS CONJUGATED TO DPA 713 ANALOGS FOR IMAGING INFLAMMATION
    Publication number: 20150044141
    Abstract: The present invention provides analog compounds of DPA-713 which specifically bind the translocator protein (TSPO), which is upregulated in activated leukocytes, some malignant tumors and tissues involved in steroid biogenesis. These compounds are linked via a linking moiety to a variety of imaging agents, including, for example, near infra-red dyes. The compounds of the present invention are useful for both pre-clinical near-IR fluorescence imaging (NIRF) and use in optically-guided interventions including NIRF endoscopy. Methods of use in diagnosis and treatment of TSPO related disease are also provided.
    Type: Application
    Filed: March 14, 2013
    Publication date: February 12, 2015
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Martin Gilbert Pomper, Haofan Wang, Catherine Anne Foss
  • TSPO-TARGETING COMPOUNDS AND USES THEREOF
    Publication number: 20140322133
    Abstract: Translocator protein (TSPO) targeting compounds are described. Methods of making the compounds, and uses of the compounds for imaging are also described.
    Type: Application
    Filed: July 14, 2014
    Publication date: October 30, 2014
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: MARTIN G. POMPER, HAOFAN WANG, TOMAS R. GUILARTE
  • TSPO-targeting compounds and uses thereof
    Patent number: 8778304
    Abstract: Translocator protein (TSPO) targeting compounds are described. Methods of making the compounds, and uses of the compounds for imaging are also described.
    Type: Grant
    Filed: February 24, 2011
    Date of Patent: July 15, 2014
    Assignee: The Johns Hopkins University
    Inventors: Martin G. Pomper, Haofan Wang, Tomas R. Guilarte
  • TSPO-TARGETING COMPOUNDS AND USES THEREOF
    Publication number: 20110212025
    Abstract: Translocator protein (TSPO) targeting compounds are described. Methods of making the compounds, and uses of the compounds for imaging are also described.
    Type: Application
    Filed: February 24, 2011
    Publication date: September 1, 2011
    Applicant: The Johns Hopkins University
    Inventors: Martin G. Pomper, Haofan Wang, Tomas R. Guilarte