Abstract: Provided are a fibroblast activation protein inhibitor (FAPI) dimer compound, an FAPI dimer-based positron emission tomography (PET) imaging agent for tumor diagnosis, and a preparation method and use thereof. An amphiphilic polyethylene glycol (PEG) chain and a dimerized structure of FAPI in the FAPI dimer compound with a structure shown in formula I can improve the in vivo kinetic properties of the compound and prolong a residence time of the compound in a tumor, thereby improving the uptake and imaging effects in the tumor. The accurate tumor diagnosis can be achieved by labeling the FAPI dimer compound with a diagnostic nuclide (68Ga), which has promising application prospects in PET imaging for diagnosis and in the preparation of a therapeutic nuclide (such as 177Lu or 90Y)-labeled drug for treating a FAP-?-expressing tumor.

Abstract: Airway adapters, suction catheter systems, and methods of using the same are described herein. An exemplary airway adapter assembly may comprise a connector body portion having a first end and a second end, an elongate cavity having an axial center can be defined between the first and the second end, and a valve can be coupled to the second end of the connector body. The exemplary airway adapter assembly may also comprise a ventilation base member comprising a tubular portion coupled to the second end of the connector body portion and ventilator port. The ventilator port may comprises a conduit having a first conduit end and a second conduit end, and the first conduit end may be coupled to the tubular portion through an articulable connection. An exemplary closed suction catheter system may comprise a suction control valve assembly and a closed suction catheter sheath.

Abstract: An exemplary suction catheter adaptor includes an adaptor body having a passageway between a proximal end and a distal end of the adaptor body. The proximal end of the adaptor body receives an instrument and, when coupled with an airway adaptor having a valve within a passageway between a proximal end and a distal end of the airway adaptor, the distal end of the adaptor body deflects the valve to permit the instrument to be advanced or retracted through the valve. A seal within the passageway of the adaptor body is biased to engage the valve during advancement of an instrument toward the valve, and the seal is disengaged when the instrument is retracted away from the valve. The valve, when not engaged, occludes the passageway between a proximal end and a distal end of the airway adaptor.

Abstract: An exemplary suction catheter adaptor includes an adaptor body having a passageway between a proximal end and a distal end of the adaptor body. The proximal end of the adaptor body receives an instrument and, when coupled with an airway adaptor having a valve within a passageway between a proximal end and a distal end of the airway adaptor, the distal end of the adaptor body deflects the valve to permit the instrument to be advanced or retracted through the valve. A seal within the passageway of the adaptor body is biased to engage the valve during advancement of an instrument toward the valve, and the seal is disengaged when the instrument is retracted away from the valve. The valve, when not engaged, occludes the passageway between a proximal end and a distal end of the airway adaptor.

Abstract: Airway adapters and suction catheter systems, and methods of using the same, are described herein. An exemplary airway adapter assembly may comprise a connector body portion having a first end and a second end. The connector body portion may define an elongate cavity having an axial center between the first and the second end. The exemplary airway adapter assembly may also comprise a valve coupled to the second end of the connector body. The exemplary airway adapter assembly may also comprise a ventilation base member comprising a tubular portion coupled to the second end of the connector body portion and ventilator port. The ventilator port may comprises a conduit having a first conduit end and a second conduit end, and the first conduit end may be coupled to the tubular portion through an articulable connection. An exemplary closed suction catheter system may comprise a suction control valve assembly and a closed suction catheter sheath.

Abstract: Airway adapters and suction catheter systems, and methods of using the same, are described herein. An exemplary airway adapter assembly may comprise a connector body portion having a first end and a second end. The connector body portion may define an elongate cavity having an axial center between the first and the second end. The exemplary airway adapter assembly may also comprise a valve coupled to the second end of the connector body. The exemplary airway adapter assembly may also comprise a ventilation base member comprising a tubular portion coupled to the second end of the connector body portion and ventilator port. The ventilator port may comprises a conduit having a first conduit end and a second conduit end, and the first conduit end may be coupled to the tubular portion through an articulable connection. An exemplary closed suction catheter system may comprise a suction control valve assembly and a closed suction catheter sheath.

Abstract: An exemplary suction catheter adaptor includes an adaptor body having a passageway between a proximal end and a distal end of the adaptor body. The proximal end of the adaptor body receives an instrument and, when coupled with an airway adaptor having a valve within a passageway between a proximal end and a distal end of the airway adaptor, the distal end of the adaptor body deflects the valve to permit the instrument to be advanced or retracted through the valve. A seal within the passageway of the adaptor body is biased to engage the valve during advancement of an instrument toward the valve, and the seal is disengaged when the instrument is retracted away from the valve. The valve, when not engaged, occludes the passageway between a proximal end and a distal end of the airway adaptor.

Abstract: Airway adapters and suction catheter systems, and methods of using the same, are described herein. An exemplary airway adapter assembly may comprise a connector body portion having a first end and a second end. The connector body portion may define an elongate cavity having an axial center between the first and the second end. The exemplary airway adapter assembly may also comprise a valve coupled to the second end of the connector body. The exemplary airway adapter assembly may also comprise a ventilation base member comprising a tubular portion coupled to the second end of the connector body portion and ventilator port. The ventilator port may comprises a conduit having a first conduit end and a second conduit end, and the first conduit end may be coupled to the tubular portion through an articulable connection. An exemplary closed suction catheter system may comprise a suction control valve assembly and a closed suction catheter sheath.

Abstract: Wash port assemblies for airway adapters and methods are described. An example wash port valve assembly may include a multi-part housing defining a cavity and comprising a cap portion having a first hardness, and a base portion having a second hardness that has a hardness value greater than the first hardness. The cap portion may define an inlet port and the base portion may define an outlet port. The valve assembly may include an elastomeric valve disposed within the cavity and may be configured to be movably retained within the multi-part housing. The elastomeric valve may comprise a valve tip portion and a valve end portion distal of the valve tip portion. An example airway adapter assembly may include an adapter housing defining a cleaning chamber, and a wash port coupling assembly coupled to the wash port of the cleaning chamber.

Abstract: The present invention relates to methods and apparatuses for the detection of positional freedom of particles used in biological, biochemical, physical, biophysical, and chemical analyses. In particular, the present invention relates to methods and apparatuses which can detect and characterize a population of particles/cells based upon their detected mobility. In one embodiment consistent with the invention, detection of certain cells is based on differences detected in populations of cells that bind to a substrate and those that exhibit weaker binding forces. Initially, cells are settled on the substrate, and in the presence of gravitational, natural thermodynamic pressure fluctuations, and other random or applied forces, some of the particles may exhibit translational movement. Particle movement is detected, and measurements are computed, according to the methods and apparatuses of the present invention, to determine the binding of specific analytes.

Abstract: A rotor is provided for use in a centrifuge system configured to spin the rotor for separating complex fluids. The rotor includes a housing configured to be secured by the centrifuge system and several chambers formed in the housing. Each chamber includes a first chamber portion having a port formed therein and a second chamber portion in fluid communication with the port of the first chamber portion. The second chamber portion may be disposed generally below the port of the first chamber portion. Other rotor designs and methods for separating complex fluids are further disclosed.

Abstract: An incubator including a container having an interior chamber capable of receiving a sample holder having samples, a lower heated surface disposed within the interior chamber of the container, and a movement mechanism coupled to the container and the lower heated surface. In one embodiment, the movement mechanism is configured to move the lower heated surface to a position in which the lower heated surface essentially contacts the sample holder. A method of rapidly heating and incubating a sample for biochemical or immunological testing is further disclosed.

Abstract: The present invention relates to methods and apparatuses for the detection of positional freedom of particles used in biological, biochemical, physical, biophysical, and chemical analyses. In particular, the present invention relates to methods and apparatuses which can detect and characterize a population of particles/cells based upon their detected mobility. In one embodiment consistent with the invention, detection of certain cells is based on differences detected in populations of cells that bind to a substrate and those that exhibit weaker binding forces. Initially, cells are settled on the substrate, and in the presence of gravitational, natural thermodynamic pressure fluctuations, and other random or applied forces, some of the particles may exhibit translational movement. Particle movement is detected, and measurements are computed, according to the methods and apparatuses of the present invention, to determine the binding of specific analytes.

Abstract: Methods and devices for evaluating a sample from a subject for detecting a target red blood cell protein or antibody are disclosed. In one embodiment, optimized antibody screening methods and devices significantly reduce the level of non-specific binding to a surface (e.g., a test surface bound with a red blood cell preparation), thus allowing for more efficient detection and reduced test time. In other embodiments, the invention provides methods and devices for target capturing that include a substantially planar surface, optionally having an optimized angle, for capture. Alternative solid phase geometries for capture are disclosed. Optimized methods for cell deposition are also disclosed. Thus, optimized methods, devices, kits, assays for evaluating a sample are disclosed.

Abstract: A rotor is provided for use in a centrifuge system configured to spin the rotor for separating complex fluids. The rotor includes a housing configured to be secured by the centrifuge system and several chambers formed in the housing. Each chamber includes a first chamber portion having a port formed therein and a second chamber portion in fluid communication with the port of the first chamber portion. The second chamber portion may be disposed generally below the port of the first chamber portion. Other rotor designs and methods for separating complex fluids are further disclosed.