Abstract: A single-operator laparoscope auxiliary operating device is provided, including a laparoscope and universal rotating mechanisms, wherein two universal rotating mechanisms are provided on the laparoscope, each of the universal rotating mechanisms includes a ball sleeve and a sleeve plate, the ball sleeve is slidably sleeved on the laparoscope, the sleeve plate is sleeved in a middle of the ball sleeve, and the ball sleeve is universally rotatable on the sleeve plate; a direction controlling mechanism; a moving mechanism; a supporting mechanism; a connecting frame, one end of the connecting frame is fixedly connected to the sleeve plate close to the lens of the laparoscope, and another end of the connecting frame is fixedly connected to the supporting mechanism; and a foot controller connected to the direction controlling mechanism and the moving mechanism.

Abstract: Crystalline forms of free base 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-phenylamino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone and preparation methods thereof are provided; the pharmaceutical formulations containing the crystalline forms and their use in the treatment of diseases, particularly angiogenic eye diseases are also provided.

Abstract: Crystalline forms of free base 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-phenylamino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone and preparation methods thereof are provided; the pharmaceutical formulations containing the crystalline forms and their use in the treatment of diseases, particularly angiogenic eye diseases are also provided.