Abstract: A method, apparatus, a computer readable medium, and an electronic device of speech synthesis. The method includes: obtaining a phoneme sequence corresponding to text to be synthesized; generating a phonemic-level TOBI representation sequence and a prosodic-acoustic feature corresponding to the text to be synthesized based on the phoneme sequence and the text to be synthesized, and generating acoustic feature information corresponding to the text to be synthesized based on the TOBI representation sequence and the prosodic-acoustic feature; and generating first audio information corresponding to the text to be synthesized based on the acoustic feature information. The method enables the synthesized audio to be more natural, cadenced, and aligned with the intended semantics of a speaker.