Patents by Inventor Haopeng Sun

Haopeng Sun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230165833
    Abstract: The present invention discloses a selective butyrylcholinesterase inhibitor having a general formula (I) or a pharmaceutically acceptable salt thereof, a preparation method and use thereof. The treatment efficacy of Alzheimer’s disease, especially moderate to severe Alzheimer’s disease, is tested through butyrylcholinesterase inhibitory activity, selectivity screening and toxicity to nerve cells as a carrier, and it is found that it has good target activity in vitro, extremely high selectivity and drug safety, can be used as a lead substance for further development of the treatment of Alzheimer’s disease by selectively inhibiting butyrylcholinesterase.
    Type: Application
    Filed: September 16, 2019
    Publication date: June 1, 2023
    Inventors: Haopeng SUN, Hongyu YANG, Tingkai CHEN, Yao CHEN, Feng FENG, Chenxi DU
  • Patent number: 10889546
    Abstract: The present invention relates to the field of pharmaceutical chemistry. In particular, the present invention relates to a class of alkynyl pyridine prolyl hydroxylase inhibitors (I). The experiments show that such a compound has good activity of inhibiting prolyl hydroxylase, and can enhance the generation and secretion of erythropoietin in cell or animal models, and thus can promote the generation of red cells, and can be used for the treatment or prevention of anemia, such as chronic kidney disease anemia, and ischemic diseases, including ischemic strokes, myocardial ischemia and other related diseases. The present invention also discloses a method for preparing such a compound.
    Type: Grant
    Filed: November 27, 2015
    Date of Patent: January 12, 2021
    Assignee: Jiangsu Hengrui Medicine Co., Ltd.
    Inventors: Qidong You, Xiaojin Zhang, Yonghua Lei, Tianhan Hu, Xingsen Wu, Haopeng Sun, Xiaoke Guo, Xiaoli Xu
  • Publication number: 20200407319
    Abstract: The present invention relates to the field of pharmaceutical chemistry. In particular, the present invention relates to a class of alkynyl pyridine prolyl hydroxylase inhibitors (I). The experiments show that such a compound has good activity of inhibiting prolyl hydroxylase, and can enhance the generation and secretion of erythropoietin in cell or animal models, and thus can promote the generation of red cells, and can be used for the treatment or prevention of anemia, such as chronic kidney disease anemia, and ischemic diseases, including ischemic strokes, myocardial ischemia and other related diseases. The present invention also discloses a method for preparing such a compound.
    Type: Application
    Filed: September 11, 2020
    Publication date: December 31, 2020
    Inventors: Qidong YOU, Xiaojin ZHANG, Yonghua LEI, Tianhan HU, Xingsen WU, Haopeng SUN, Xiaoke GUO, Xiaoli XU
  • Patent number: 10442759
    Abstract: Compounds of formula (I) having 1-sulfonamido-4-aryloxy as a basic backbone. A preliminary activity test showed that the compounds provide excellent interference of a binding of Nrf2 by Keap1, thereby activating Nrf2. The compounds have a potential anti-inflammatory activity and can be used to treat a plurality of inflammation-associated diseases, including chronic obstructive pulmonary disease (COPD), Alzheimer's disease, Parkinson's disease, atherosclerosis, chronic kidney disease (CKD), diabetes, gastroenteritis, rheumatoid arthritis, and the like.
    Type: Grant
    Filed: November 25, 2016
    Date of Patent: October 15, 2019
    Assignee: CHINA PHARMACEUTICAL UNIVERSITY
    Inventors: Qidong You, Zhengyu Jiang, Mengchen Lu, Zhiyun Chen, Haopeng Sun, Xiaojin Zhang, Xiaoke Guo, Xiaoli Xu
  • Publication number: 20180305317
    Abstract: The present invention relates to the field of pharmaceutical chemistry. In particular, the present invention relates to a class of alkynyl pyridine prolyl hydroxylase inhibitors (I). The experiments show that such a compound has good activity of inhibiting prolyl hydroxylase, and can enhance the generation and secretion of erythropoietin in cell or animal models, and thus can promote the generation of red cells, and can be used for the treatment or prevention of anemia, such as chronic kidney disease anemia, and ischemic diseases, including ischemic strokes, myocardial ischemia and other related diseases. The present invention also discloses a method for preparing such a compound.
    Type: Application
    Filed: November 27, 2015
    Publication date: October 25, 2018
    Inventors: Qidong YOU, Xiaojin ZHANG, Yonghua LEI, Tianhan HU, Xingsen WU, Haopeng SUN, Xiaoke GUO, Xiaoli XU
  • Publication number: 20180251423
    Abstract: Compounds of formula (I) having 1-sulfonamido-4-aryloxy as a basic backbone. A preliminary activity test showed that the compounds provide excellent interference of a binding of Nrf2 by Keap1, thereby activating Nrf2. The compounds have a potential anti-inflammatory activity and can be used to treat a plurality of inflammation-associated diseases, including chronic obstructive pulmonary disease (COPD), Alzheimer's disease, Parkinson's disease, atherosclerosis, chronic kidney disease (CKD), diabetes, gastroenteritis, rheumatoid arthritis, and the like.
    Type: Application
    Filed: November 25, 2016
    Publication date: September 6, 2018
    Applicant: CHINA PHARMACEUTICAL UNIVERSITY
    Inventors: Qidong YOU, Zhengyu JIANG, Mengchen LU, Zhiyun CHEN, Haopeng SUN, Xiaojin ZHANG, Xiaoke GUO, Xiaoli XU
  • Publication number: 20150070361
    Abstract: The present invention provides a character conversion system, comprising: a parsing unit, used to parse received data, determine at least one character contained in the data, and obtain property information corresponding to each character of the at least one character; a judging unit, used to, with respect to each character, determine a pattern bitmap of the character according to the property information, and judge whether the pattern bitmap satisfies a preset condition; a conversion unit, used to, if the judging unit judges that the preset condition is satisfied, determine an original inner code of the character according to the property information, and convert the character according to the original inner code; and if the judging unit judges that the preset condition is not satisfied, identify an actual inner code of the character according to the pattern bitmap, and convert the character according to the actual inner code.
    Type: Application
    Filed: December 3, 2013
    Publication date: March 12, 2015
    Applicants: Peking University Founder Group Co., Ltd., Founder Information Industry Group, Founder Apabi Technology Limited
    Inventors: Jianbo Xu, Haopeng Sun, Li Ding, Haitao Wang, Leilei Geng