Patents by Inventor Haowen XU

Haowen XU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10385345
    Abstract: The present invention is directed to a yeast strain, or strains, secreting a full suite, or any subset of that full suite, of enzymes to hydrolyze corn starch, corn fiber, lignocellulose, (including enzymes that hydrolyze linkages in cellulose, hemicellulose, and between lignin and carbohydrates) and to utilize pentose sugars (xylose and arabinose). The invention is also directed to the set of proteins that are well expressed in yeast for each category of enzymatic activity. The resulting strain, or strains can be used to hydrolyze starch and cellulose simultaneously. The resulting strain, or strains can be also metabolically engineered to produce less glycerol and uptake acetate. The resulting strain, or strains can also be used to produce ethanol from granular starch without liquefaction.
    Type: Grant
    Filed: May 2, 2017
    Date of Patent: August 20, 2019
    Assignees: Lallemand Hungary Liquidity Management LLC, Universiteit Stellenbosch
    Inventors: Elena Brevnova, John E. McBride, Erin Wiswall, Kevin S. Wenger, Nicky Caiazza, Heidi Hau, Aaron Argyros, Frank Agbogbo, Charles F. Rice, Trisha Barrett, John S. Bardsley, Abigail Foster, Anne K. Warner, Mark Mellon, Ryan Skinner, Indraneel Shikhare, Riaan Den Haan, Chhayal V. Gandhi, Alan Belcher, Vineet B. Rajgarhia, Allan C. Froehlich, Kristen M. Deleault, Emily Stonehouse, Shital A. Tripathi, Jennifer Gosselin, Yin-Ying Chiu, Haowen Xu
  • Patent number: 10378033
    Abstract: The present application relates to reaction mixtures comprising biomass, a solid acid catalyst and cellulolytic enzymes or organisms expressing such enzymes for converting biomass to useful feedstocks and methods of forming products via fermentation using the said reaction mixture.
    Type: Grant
    Filed: April 12, 2016
    Date of Patent: August 13, 2019
    Assignee: BASF Corporation
    Inventors: Haowen Xu, Sharad Mathur, Karin Arens
  • Patent number: 10294484
    Abstract: The present invention is directed to a yeast strain, or strains, secreting a full suite, or any subset of that full suite, of enzymes to hydrolyze corn starch, corn fiber, lignocellulose, (including enzymes that hydrolyze linkages in cellulose, hemicellulose, and between lignin and carbohydrates) and to utilize pentose sugars (xylose and arabinose). The invention is also directed to the set of proteins that are well expressed in yeast for each category of enzymatic activity. The resulting strain, or strains can be used to hydrolyze starch and cellulose simultaneously. The resulting strain, or strains can be also metabolically engineered to produce less glycerol and uptake acetate. The resulting strain, or strains can also be used to produce ethanol from granular starch without liquefaction.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: May 21, 2019
    Assignees: Lallemand Hungary Liquidity Management LLC, Stellenbosch University
    Inventors: Elena Brevnova, John E. McBride, Erin Wiswall, Kevin S. Wenger, Nicky Caiazza, Heidi Lau, Aaron Argyros, Frank Agbogbo, Charles F. Rice, Trisha Barrett, John S. Bardsley, Abigail Foster, Anne K. Warner, Mark Mellon, Ryan Skinner, Indraneel Shikhare, Riaan Den Haan, Chhayal V. Gandhi, Alan Belcher, Vineet B. Rajgarhia, Allan C. Froehlich, Kristen M. Deleault, Emily Stonehouse, Shital A. Tripathi, Jennifer Gosselin, Yin-Ying Chiu, Haowen Xu
  • Publication number: 20180258449
    Abstract: The present invention is directed to cellulytic host cells. The host cells of the invention expressing heterologous cellulases and are able to produce ethanol from cellulose. According to the invention, host cells expressing a combination of heterologous cellulases can be used to produce ethanol from cellulose. In addition, multiple host cells expressing different heterologous cellulases can be co-cultured together and used to produce ethanol from cellulose. Furthermore, the invention demonstrates for the first time the ability of Kluyveromyces to produce ethanol from cellulose. The yeast strains and co-cultures of yeast strains of the invention can be used to produce ethanol on their own, or can also be used in combination with externally added cellulases to increase the efficiency of saccharification and fermentation processes.
    Type: Application
    Filed: May 21, 2018
    Publication date: September 13, 2018
    Inventors: John McBride, Elena Brevnova, Mark Mellon, Allan Froehlich, Kristen Deleault, Vineet Rajgarhia, Riaan Den Haan, Merja Penttila, Marja Ilmen, Matti Siika-Aho, Jaana Uusitalo, Emily A. Stonehouse, Alan Gilbert, Haowen Xu, Deidre Willies, John Bardsley, Anu Koivula, Sanni Voutilainen
  • Patent number: 9988652
    Abstract: The present invention is directed to cellulytic host cells. The host cells of the invention expressing heterologous cellulases and are able to produce ethanol from cellulose. According to the invention, host cells expressing a combination of heterologous cellulases can be used to produce ethanol from cellulose. In addition, multiple host cells expressing different heterologous cellulases can be co-cultured together and used to produce ethanol from cellulose. Furthermore, the invention demonstrates for the first time the ability of Kluveryomyces to produce ethanol from cellulose. The yeast strains and co-cultures of yeast strains of the invention can be used to produce ethanol on their own, or can also be used in combination with externally added cellulases to increase the efficiency of saccharification and fermentation processes.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: June 5, 2018
    Assignees: Lallemand Hungary Liquidity Management LLC, Stellenbosch University
    Inventors: John McBride, Elena Brevnova, Mark Mellon, Allan Froehlich, Kristen Deleault, Vineet Rajgarhia, Riaan Den Haan, Merja Penttila, Marja Ilmen, Matti Siika-Aho, Jaana Uusitalo, Emily A. Stonehouse, Alan Gilbert, Haowen Xu, Deidre Willes, John Bardsley, Anu Koivula, Sanni Voutilainen
  • Publication number: 20180100174
    Abstract: The present application relates to reaction mixtures comprising biomass, a solid acid catalyst and celluloytic enzymes or organisms expressing such enzymes for converting biomass to useful feedstocks and methods of forming products via fermentation using the said reaction mixture.
    Type: Application
    Filed: April 12, 2016
    Publication date: April 12, 2018
    Inventors: Haowen XU, Sharad MATHUR, Karin ARENS
  • Patent number: 9745560
    Abstract: The present invention provides a multi-component enzyme system that hydrolyzes hemicellulose oligomers from hardwood which can be expressed, for example, in yeast such as Saccharomyces cerevisiae. In some embodiments, this invention provides for the engineering of a series of biocatalysts combining the expression and secretion of components of this enzymatic system with robust, rapid xylose utilization, and ethanol fermentation under industrially relevant process conditions for consolidated bioprocessing. In some embodiments, the invention utilizes co-cultures of strains that can achieve significantly improved performance due to the incorporation of additional enzymes in the fermentation system.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: August 29, 2017
    Assignee: Lallemand Hungary Liquidity Management LLC
    Inventors: John E. McBride, Erin Wiswall, Indraneel Shikhare, Haowen Xu, Naomi Thorngren, Heidi H. Hau, Emily Stonehouse
  • Publication number: 20170240906
    Abstract: The present invention is directed to a yeast strain, or strains, secreting a full suite, or any subset of that full suite, of enzymes to hydrolyze corn starch, corn fiber, lignocellulose, (including enzymes that hydrolyze linkages in cellulose, hemicellulose, and between lignin and carbohydrates) and to utilize pentose sugars (xylose and arabinose). The invention is also directed to the set of proteins that are well expressed in yeast for each category of enzymatic activity. The resulting strain, or strains can be used to hydrolyze starch and cellulose simultaneously. The resulting strain, or strains can be also metabolically engineered to produce less glycerol and uptake acetate. The resulting strain, or strains can also be used to produce ethanol from granular starch without liquefaction.
    Type: Application
    Filed: May 2, 2017
    Publication date: August 24, 2017
    Inventors: Elena Brevnova, John E. McBride, Erin Wiswall, Kevin S. Wenger, Nicky Caiazza, Heidi Hau, Aaron Argyros, Frank Agbogbo, Charles F. Rice, Trisha Barrett, John S. Bardsley, Abigail Foster, Anne K. Warner, Mark Mellon, Ryan Skinner, Indraneel Shikhare, Riaan Den Haan, Chhayal V. Gandhi, Alan Belcher, Vineet B. Rajgarhia, Allan C. Froehlich, Kristen M. Deleault, Emily Stonehouse, Shital A. Tripathi, Jennifer Gosselin, Yin-Ying Chiu, Haowen Xu
  • Patent number: 9642284
    Abstract: Embodiments of the present invention relate to an RRU device and an assembly thereof. The RRU device includes: an enclosure, where the enclosure includes a front-end plate and a back-end plate that are respectively set on two lengthwise ends of the enclosure, multiple parallel spaced heat sinks are set on two widthwise sides of the enclosure and between the front-end plate and the back-end plate, and the front-end plate and the back-end plate extend along a widthwise direction of the enclosure by a length which is greater than a length by which the heat sinks extend; and a joint part set on the enclosure, where the joint part is used to fasten two side-by-side radio remote unit devices together.
    Type: Grant
    Filed: September 1, 2015
    Date of Patent: May 2, 2017
    Assignee: HUAWEI TECHNOLOGIES CO., LTD.
    Inventors: Jinsong Lv, Chenglong Wang, Haowen Xu, Zuojun Qin, Haizheng Tang, Lili Guo, Jin Jiang, Zhongxin Liu
  • Patent number: 9605269
    Abstract: One aspect of the invention relates to a genetically modified thermophilic or mesophilic microorganism, wherein a first native gene is partially, substantially, or completely deleted, silenced, inactivated, or down-regulated, which first native gene encodes a first native enzyme involved in the metabolic production of an organic acid or a salt thereof, thereby increasing the native ability of said thermophilic or mesophilic microorganism to produce lactate or acetate as a fermentation product. In certain embodiments, the aforementioned microorganism further comprises a first non-native gene, which first non-native gene encodes a first non-native enzyme involved in the metabolic production of lactate or acetate. Another aspect of the invention relates to a process for converting lignocellulosic biomass to lactate or acetate, comprising contacting lignocellulosic biomass with a genetically modified thermophilic or mesophilic microorganism.
    Type: Grant
    Filed: May 5, 2011
    Date of Patent: March 28, 2017
    Assignee: Lallemand Hungary Liquidity Management LLC
    Inventors: William Ryan Sillers, Hans Van Dijken, Steve Licht, Arthur J. Shaw, IV, Alan Benjamin Gilbert, Aaron Argyros, Allan C. Froehlich, John E. McBride, Haowen Xu, David A. Hogsett, Vineet B. Rajgarhia
  • Publication number: 20160068850
    Abstract: The present invention is directed to a yeast strain, or strains, secreting a full suite, or any subset of that full suite, of enzymes to hydrolyze corn starch, corn fiber, lignocellulose, (including enzymes that hydrolyze linkages in cellulose, hemicellulose, and between lignin and carbohydrates) and to utilize pentose sugars (xylose and arabinose). The invention is also directed to the set of proteins that are well expressed in yeast for each category of enzymatic activity. The resulting strain, or strains can be used to hydrolyze starch and cellulose simultaneously. The resulting strain, or strains can be also metabolically engineered to produce less glycerol and uptake acetate. The resulting strain, or strains can also be used to produce ethanol from granular starch without liquefaction.
    Type: Application
    Filed: November 10, 2015
    Publication date: March 10, 2016
    Inventors: Elena Brevnova, John E. McBride, Erin Wiswall, Kevin S. Wenger, Nicky Caiazza, Heidi Lau, Aaron Argyros, Frank Agbogbo, Charles F. Rice, Trisha Barrett, John S. Bardsley, Abigail Foster, Anne K. Warner, Mark Mellon, Ryan Skinner, Indraneel Shikhare, Riaan Den Haan, Chhayal V. Gandhi, Alan Belcher, Vineet B. Rajgarhia, Allan C. Froehlich, Kristen M. Deleault, Emily Stonehouse, Shital A. Tripathi, Jennifer Gosselin, Yin-Ying Chiu, Haowen Xu
  • Publication number: 20160010117
    Abstract: The present invention is directed to cellulytic host cells. The host cells of the invention expressing heterologous cellulases and are able to produce ethanol from cellulose. According to the invention, host cells expressing a combination of heterologous cellulases can be used to produce ethanol from cellulose. In addition, multiple host cells expressing different heterlogous cellulases can be co-cultured together and used to produce ethanol from cellulose. Furthermore, the invention demonstrates for the first time the ability of Kluveryomyces to produce ethanol from cellulose. The yeast strains and co-cultures of yeast strains of the invention can be used to produce ethanol on their own, or can also be used in combination with externally added cellulases to increase the efficiency of saccharification and fermentation processes.
    Type: Application
    Filed: July 1, 2015
    Publication date: January 14, 2016
    Inventors: John McBride, Elena Brevnova, Mark Mellon, Allan Froehlich, Kristen Deleault, Vineet Rajgarhia, Riaan Den Haan, Merja Penttila, Marja Ilmen, Matti Siika-Aho, Jaana Uusitalo, Emily A. Stonehouse, Alan Gilbert, Haowen Xu, Deidre Willes, John Bardsley, Anu Koivula, Sanni Voutilainen
  • Publication number: 20150373871
    Abstract: Embodiments of the present invention relate to an RRU device and an assembly thereof The RRU device includes: an enclosure, where the enclosure includes a front-end plate and a back-end plate that are respectively set on two lengthwise ends of the enclosure, multiple parallel spaced heat sinks are set on two widthwise sides of the enclosure and between the front-end plate and the back-end plate, and the front-end plate and the back-end plate extend along a widthwise direction of the enclosure by a length which is greater than a length by which the heat sinks extend; and a joint part set on the enclosure, where the joint part is used to fasten two side-by-side radio remote unit devices together.
    Type: Application
    Filed: September 1, 2015
    Publication date: December 24, 2015
    Inventors: Jinsong Lv, Chenglong Wang, Haowen Xu, Zuojun Qin, Haizheng Tang, Lili Guo, Jin Jiang, Zhongxin Liu
  • Patent number: 9206444
    Abstract: The present invention is directed to a yeast strain, or strains, secreting a full suite, or any subset of that full suite, of enzymes to hydrolyze corn starch, corn fiber, lignocellulose, (including enzymes that hydrolyze linkages in cellulose, hemicellulose, and between lignin and carbohydrates) and to utilize pentose sugars (xylose and arabinose). The invention is also directed to the set of proteins that are well expressed in yeast for each category of enzymatic activity. The resulting strain, or strains can be used to hydrolyze starch and cellulose simultaneously. The resulting strain, or strains can be also metabolically engineered to produce less glycerol and uptake acetate. The resulting strain, or strains can also be used to produce ethanol from granular starch without liquefaction.
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: December 8, 2015
    Assignees: Lallemand Hungary Liquidity Management LLC, Stellenbosch University
    Inventors: Elena Brevnova, John E. McBride, Erin Wiswall, Kevin S. Wenger, Nicky Caiazza, Heidi Hau, Aaron Argyros, Frank Agbogbo, Charles F. Rice, Trisha Barrett, John S. Bardsley, Abigail Foster, Anne K. Warner, Mark Mellon, Ryan Skinner, Indraneel Shikhare, Riaan Den Haan, Chhayal V. Gandhi, Alan Belcher, Vineet B. Rajgarhia, Allan C. Froehlich, Kristen M. Deleault, Emily Stonehouse, Shital A. Tripathi, Jennifer Gosselin, Yin-Ying Chiu, Haowen Xu
  • Patent number: 9167712
    Abstract: Embodiments of the present invention relate to an RRU device and an assembly thereof. The RRU device includes: an enclosure, where the enclosure includes a front-end plate and a back-end plate that are respectively set on two lengthwise ends of the enclosure, multiple parallel spaced heat sinks are set on two widthwise sides of the enclosure and between the front-end plate and the back-end plate, and the front-end plate and the back-end plate extend along a widthwise direction of the enclosure by a length which is greater than a length by which the heat sinks extend; and a joint part set on the enclosure, where the joint part is used to fasten two side-by-side radio remote unit devices together.
    Type: Grant
    Filed: May 31, 2013
    Date of Patent: October 20, 2015
    Assignee: HUAWEI TECHNOLOGIES CO., LTD.
    Inventors: Jinsong Lv, Chenglong Wang, Haowen Xu, Zuojun Qin, Haizheng Tang, Lili Guo, Jin Jiang, Zhongxin Liu
  • Publication number: 20150225705
    Abstract: The present invention provides a multi-component enzyme system that hydrolyzes hemicellulose oligomers from hardwood which can be expressed, for example, in yeast such as Saccharomyces cerevisiae. In some embodiments, this invention provides for the engineering of a series of biocatalysts combining the expression and secretion of components of this enzymatic system with robust, rapid xylose utilization, and ethanol fermentation under industrially relevant process conditions for consolidated bioprocessing. In some embodiments, the invention utilizes co-cultures of strains that can achieve significantly improved performance due to the incorporation of additional enzymes in the fermentation system.
    Type: Application
    Filed: March 15, 2013
    Publication date: August 13, 2015
    Applicant: Lallemand Hungary Liquidity Management LLC
    Inventors: John E. McBride, Erin Wiswall, Indraneel Shikhare, Haowen Xu, Naomi Thorngren, Heidi H. Hau, Emily Stonehouse
  • Patent number: 9102955
    Abstract: Host cells, comprising Kluveryomyces expressing heterologous cellulases produce ethanol from cellulose In addition, multiple host cells expressing different heterlogous cellulases can be co-cultured together and used to produce ethanol from cellulose The recombinant yeast strains and co-cultures of the yeast strains can be used to produce ethanol on their own, or can also be used in combination with externally added cellulases to increase the efficiency of sacchanfication and fermentation processes.
    Type: Grant
    Filed: November 23, 2009
    Date of Patent: August 11, 2015
    Assignee: Lallemand Hungary Liquidity Management LLC
    Inventors: John McBride, Elena Brevnova, Mark Mellon, Allan Froehlich, Kristen Deleault, Vineet Rajgarhia, Riaan Den Haan, Merja Penttila, Marja Ilmen, Matti Siika-Aho, Jaana Uusitalo, Emily A. Stonehouse, Alan Gilbert, Haowen Xu, Deidre Willes, John Bardsley, Anu Koivula, Sanni Voutilainen
  • Publication number: 20140308724
    Abstract: The present invention is directed to a yeast strain, or strains, secreting a full suite, or any subset of that full suite, of enzymes to hydrolyze corn starch, corn fiber, lignocellulose, (including enzymes that hydrolyze linkages in cellulose, hemicellulose, and between lignin and carbohydrates) and to utilize pentose sugars (xylose and arabinose). The invention is also directed to the set of proteins that are well expressed in yeast for each category of enzymatic activity. The resulting strain, or strains can be used to hydrolyze starch and cellulose simultaneously. The resulting strain, or strains can be also metabolically engineered to produce less glycerol and uptake acetate. The resulting strain, or strains can also be used to produce ethanol from granular starch without liquefaction.
    Type: Application
    Filed: February 12, 2014
    Publication date: October 16, 2014
    Applicants: Stellenbosch University, Mascoma Corporation
    Inventors: Elena BREVNOVA, John E. McBride, Erin Wiswall, Kevin S. Wenger, Nicky Caiazza, Heidi Hau, Aaron Argyros, Frank Agbogbo, Charles F. Rice, Trisha Barrett, John S. Bardsley, Abigail Foster, Anne K. Warner, Mark Mellon, Ryan Skinner, Indraneel Shikhare, Riaan Den Haan, Chhayal V. Gandhi, Alan Belcher, Vineet B. Rajgarhia, Allan C. Froehlich, Kristen M. Deleault, Emily Stonehouse, Shital A. Tripathi, Jennifer Gosselin, Yin-Ying Chiu, Haowen Xu
  • Publication number: 20140043767
    Abstract: Embodiments of the present invention relate to an RRU device and an assembly thereof. The RRU device includes: an enclosure, where the enclosure includes a front-end plate and a back-end plate that are respectively set on two lengthwise ends of the enclosure, multiple parallel spaced heat sinks are set on two widthwise sides of the enclosure and between the front-end plate and the back-end plate, and the front-end plate and the back-end plate extend along a widthwise direction of the enclosure by a length which is greater than a length by which the heat sinks extend; and a joint part set on the enclosure, where the joint part is used to fasten two side-by-side radio remote unit devices together.
    Type: Application
    Filed: May 31, 2013
    Publication date: February 13, 2014
    Applicant: Huawei Technologies Co., Ltd.
    Inventors: Jinsong Lv, Chenglong Wang, Haowen Xu, Zuojun Qin, Haizheng Tang, Lili Guo, Jin Jiang, Zhongxin Liu
  • Publication number: 20130323822
    Abstract: The present invention is directed to a yeast strain, or strains, secreting a full suite, or any subset of that full suite, of enzymes to hydrolyze corn starch, corn fiber, lignocellulose, (including enzymes that hydrolyze linkages in cellulose, hemicellulose, and between lignin and carbohydrates) and to utilize pentose sugars (xylose and arabinose). The invention is also directed to the set of proteins that are well expressed in yeast for each category of enzymatic activity. The resulting strain, or strains can be used to hydrolyze starch and cellulose simultaneously. The resulting strain, or strains can be also metabolically engineered to produce less glycerol and uptake acetate. The resulting strain, or strains can also be used to produce ethanol from granular starch without liquefaction.
    Type: Application
    Filed: June 3, 2011
    Publication date: December 5, 2013
    Applicant: Mascoma Corporation
    Inventors: Elena Brevnova, John E. McBride, Erin Wiswall, Kevin S. Wenger, Nicky Caiazza, Heidi Hau, Aaron Argyros, Frank Agbogbo, Charles F. Rice, Trisha Barrett, John S. Bardsley, Abigail S. Foster, Anne K. Warner, Mark Mellon, Ryan Skinner, Indraneel Shikhare, Riaan Den Haan, Chhayal V. Gandhi, Alan Belcher, Vineet B. Rajgarhia, Allan C. Froehlich, Kristen M. Deleault, Emily Stonehouse, Shital A. Tripathi, Jennifer Gosselin, Yin-Ying Chiu, Haowen Xu