Abstract: The present invention discloses a fabrication method and use of a ?40 mm large-size and high-contrast fiber optic image inverter, belonging to the field of manufacturing of fiber optic imaging elements. The light-absorbing glass for preparing the ?40 mm large-size and high-contrast fiber optic image inverter consists of the following components in molar percentage: SiO2 60-69.9, Al2O3 1.0-10.0, B2O3 10.1-15.0, Na2O 1.0-8.0, K2O 3.0-10.0, MgO 0.1-1.0, CaO 0.5-5.0, ZnO 0-0.1, TiO2 0-0.1, ZrO2 0.1-1.0, Fe2O3 3.0-6.5, Co2O3 0.1-0.5, V2O5 0.51-1.5 and MoO3 0.1-1.0. The fiber optic image inverter has the advantages of low crosstalk of stray light, high resolution and high contrast.

Abstract: The present invention discloses a glass with high refractive index for fiber optic imaging elements with medium-expansion and fabrication method therefor, the glass comprising the following components in percentage by weight: SiO2 5-9%, Al2O3 0-1%, B2O3 23-28%, CaO 0-3%, BaO 6-12%, La2O3 30-34%, Nb2O5 4-8%, Ta2O5 0-1%, Y2O3 0-1%, ZnO 4-9%, TiO2 4-8%, ZrO2 4-6%, SnO2 0-1%. The present invention further provides a fabrication method for the glass with a high refractive index, comprising: putting raw materials quartz sand, aluminum hydroxide, boric acid or boric anhydride, calcium carbonate, barium carbonate or barium nitrate, lanthanum oxide, niobium oxide, tantalum oxide, yttrium oxide, zinc oxide, titanium dioxide, zirconium oxide and stannic oxide, etc. into a platinum crucible according to the requirement of dosing, melting at a high temperature, cooling and fining, leaking and casting to form a glass rod, and then annealing, cooling and chilling the molded glass rod.

Abstract: A fiber optic imaging element includes medium-expansion and a fabrication method including: (1) matching a core glass rod with a cladding glass tube to perform mono fiber drawing; (2) arranging the mono fibers into a mono fiber bundle rod, and then drawing the mono fiber bundle rod into a multi fiber; (3) arranging the multi fiber into a multi fiber bundle rod, and then drawing the multi fiber bundle rod into a multi-multi fiber; (4) cutting the multi-multi fiber, and then arranging the multi-multi fiber into a fiber assembly buddle, then putting the fiber assembly buddle into a mold of heat press fusion process, and performing the heat press fusion process to prepare a block of the fiber optic imaging element with medium-expansion; and (5) edged rounding, cutting and slicing, face grinding and polishing the prepared medium-expansion block into a billet.

Abstract: The present invention discloses a glass with high refractive index for fiber optic imaging elements with medium-expansion and fabrication method therefor, the glass comprising the following components in percentage by weight: SiO2 5-9%, Al2O3 0-1%, B2O3 23-28%, CaO 0-3%, BaO 6-12%, La2O3 30-34%, Nb2O5 4-8%, Ta2O5 0-1%, Y2O3 0-1%, ZnO 4-9%, TiO2 4-8%, ZrO2 4-6%, SnO2 0-1%. The present invention further provides a fabrication method for the glass with a high refractive index, comprising: putting raw materials quartz sand, aluminum hydroxide, boric acid or boric anhydride, calcium carbonate, barium carbonate or barium nitrate, lanthanum oxide, niobium oxide, tantalum oxide, yttrium oxide, zinc oxide, titanium dioxide, zirconium oxide and stannic oxide, etc. into a platinum crucible according to the requirement of dosing, melting at a high temperature, cooling and fining, leaking and casting to form a glass rod, and then annealing, cooling and chilling the molded glass rod.

Abstract: A fiber optic imaging element includes medium-expansion and a fabrication method including: (1) matching a core glass rod with a cladding glass tube to perform mono fiber drawing; (2) arranging the mono fibers into a mono fiber bundle rod, and then drawing the mono fiber bundle rod into a multi fiber; (3) arranging the multi fiber into a multi fiber bundle rod, and then drawing the multi fiber bundle rod into a multi-multi fiber; (4) cutting the multi-multi fiber, and then arranging the multi-multi fiber into a fiber assembly buddle, then putting the fiber assembly buddle into a mold of heat press fusion process, and performing the heat press fusion process to prepare a block of the fiber optic imaging element with medium-expansion; and (5) edged rounding, cutting and slicing,

Abstract: Provided in the present invention is a bispecific antibody which comprises an anti-MUC1 VHH antibody fragment and an anti-CD16 VHH antibody fragment. The antibody fragment used in the present invention is a variable region sequence derived from a heavy chain camelid antibody and has a high binding affinity to the antigen. Antibody fragments recognizing MUC1 and CD16 are constructed in the same antibody molecule by the invention, so that the antibody molecule can specifically bind to MUC1 and CD16 molecules to promote the killing effect of NK cells on MUC1-positive expression cells and has an inhibiting effect on the growth of MUC1-positive tumors. Also provided is a conjugate of the bispecific antibodies, a related pharmaceutical composition and use.

Abstract: The present invention relates to a multi-specific antibody conjugate (such as, a bispecific antibody conjugate), and a related composition, therapeutic method and use thereof. The antibody conjugate comprises a multispecific antibody, such as a bispecific antibody, conjugated to a nanomaterial. The antibody conjugate can be used to modulate an immune response, treat or prevent a disease or condition (e.g., a cancer, autoimmune disease, pathogen infection or inflammatory disease), etc.

Abstract: The present invention relates to a multi-specific binding conjugate, a related composition and use. The binding conjugate comprises binding moieties for two or more different receptors, co-receptors, antigens or cellular markers which moieties are coupled by a nanomaterial. The multi-specific binding conjugate can be used to modulate an immune response, treat or prevent a disease or condition (e.g., a cancer, autoimmune disease, pathogen infection or inflammatory disease).

Abstract: The present invention relates to a multi-specific binding conjugate, a related composition and use. The binding conjugate comprises binding moieties for two or more different receptors, co-receptors, antigens or cellular markers which moieties are coupled by a nanomaterial. The multi-specific binding conjugate can be used to modulate an immune response, treat or prevent a disease or condition (e.g., a cancer, autoimmune disease, pathogen infection or inflammatory disease).

Abstract: The present invention provides a bispecific antibody capable of being combined with immune cells to enhance a targeting tumor killing capability, and a preparation method therefor and an application thereof. Antibodies and degradable nanoparticles are connected by using a chemical method, so as to make the one nanoparticle be connected to two or more antibody molecules at the same time, wherein one antibody can be specifically bound with immune cells, and the other antibody or the other antibodies can be specifically bound to tumor cells so as to achieve the effect of enhancing the capability of the immune cells for specifically killing tumor cells in a targeting way.

Abstract: The present invention provides a bispecific antibody capable of being combined with immune cells to enhance a targeting tumor killing capability, and a preparation method therefor and an application thereof. Antibodies and degradable nanoparticles are connected by using a chemical method, so as to make the one nanoparticle be connected to two or more antibody molecules at the same time, wherein one antibody can be specifically bound with immune cells, and the other antibody or the other antibodies can be specifically bound to tumor cells so as to achieve the effect of enhancing the capability of the immune cells for specifically killing tumor cells in a targeting way.

Abstract: The present invention relates to a multi-specific antibody conjugate (such as, a bispecific antibody conjugate), and a related composition, therapeutic method and use thereof. The antibody conjugate comprises a multispecific antibody, such as a bispecific antibody, conjugated to a nanomaterial. The antibody conjugate can be used to modulate an immune response, treat or prevent a disease or condition (e.g., a cancer, autoimmune disease, pathogen infection or inflammatory disease), etc.

Abstract: Provided in the present invention is a bispecific antibody which comprises an antibody fragment of anti-MUC1 VHH and an antibody fragment of anti-CD16 VHH. The antibody fragment used in the present invention is a variable region sequence derived from a heavy chain camelid antibody and has a high binding affinity to the antigen. Antibody fragments recognizing MUC1 and CD16 are constructed in the same antibody molecule by the invention, so that the antibody molecule can specifically bind to MUC1 and CD16 molecules to promote the killing effect of NK cells on MUC1-positive expression cells and has an inhibiting effect on the growth of MUC1-positive tumors. Also provided is a conjugate of the bispecific antibodies, a related pharmaceutical composition and use.

Abstract: The present invention relates to a multi-specific binding conjugate, a related composition and use. The binding conjugate comprises binding moieties for two or more different receptors, co-receptors, antigens or cellular markers which moieties are coupled by a nanomaterial. The multi-specific binding conjugate can be used to modulate an immune response, treat or prevent a disease or condition (e.g., a cancer, autoimmune disease, pathogen infection or inflammatory disease).

Abstract: The present invention provides a marker used for detecting colon cancer, and also provides application of said marker in the detection of colon cancer, as well as an associated kit and detection method.

Abstract: Provided herein are apparatus and methods for power enhancement of self-biased distributed amplifiers with gate bias networks. By sampling output power a gate bias network with a filter network can adjust gate bias so as to improve the P1 dB compression point and the Psat saturation power level of a self-biased distributed amplifier. Advantageously the filter network can be derived using passive components thereby making it an easy to implement and cost effective approach to improve linearity and output power.

Abstract: The present invention provides a bispecific antibody capable of being combined with immune cells to enhance a targeting tumor killing capability, and a preparation method therefor and an application thereof. Antibodies and degradable nanoparticles are connected by using a chemical method, so as to make the one nanoparticle be connected to two or more antibody molecules at the same time, wherein one antibody can be specifically bound with immune cells, and the other antibody or the other antibodies can be specifically bound to tumor cells so as to achieve the effect of enhancing the capability of the immune cells for specifically killing tumor cells in a targeting way.

Abstract: The present invention provides a marker used for detecting colon cancer, and also provides application of said marker in the detection of colon cancer, as well as an associated kit and detection method.

Abstract: Provided herein are apparatus and methods for power enhancement of self-biased distributed amplifiers with gate bias networks. By sampling output power a gate bias network with a filter network can adjust gate bias so as to improve the P1 dB compression point and the Psat saturation power level of a self-biased distributed amplifier. Advantageously the filter network can be derived using passive components thereby making it an easy to implement and cost effective approach to improve linearity and output power.

Abstract: This invention provides a homologous recombination-based nucleic acid molecular cloning method. According to the method of the present invention, a target DNA is cloned into a vector through homologous recombination by providing a linearized vector with both ends respectively added with a sequence (namely, a target DNA-specific homologous arm) homologous with sequences of both ends of the target DNA or a flank sequence thereof, or by utilizing a ligation fragment containing both the target DNA-specific homologous arm and a vector-specific homologous arm (a sequence homologous with a specific region of the vector). The method of the present invention is especially applicable to the cloning of a large DNA fragment and to the studies of single nucleotide polymorphism. The present invention further provides a related kit.