Abstract: Disclosed is a pyridazinone compound represented by Formula (I), or a pharmaceutically acceptable salt, prodrug, hydrate, solvate, polymorph, stereoisomer, or isotopic variant thereof. The compound can be used for preparation of medicinal products for treatment and/or prophylaxis of a disease or condition associated with thyroid hormone abnormalities. The compound has higher selectivity to TH?, better pharmacokinetic parameters, desired stability, and higher agonistic activity toward TH?.

Abstract: A display panel includes a display region and a photoelectric sensing region which includes a light transmitting region and a frame region surrounding the light transmitting region; the frame region includes a first region surrounding the light transmitting region, a second region on a side of the first region away from the light transmitting region and surrounding the first region, and a third region between the second region and the display region. The spacers are in an array and in the display region but not in the light transmitting region. A plurality of first support pillars are in the first region, arranged around the light transmitting region, and spaced from each other. A plurality of second support pillars are in the second region, around the second region, and spaced from each other. A plurality of third support pillars are in the third region in an array.

Abstract: A method for preparing a non-human mammal or progeny thereof, and the use thereof. The preparation method includes making a CH1 domain of an IgM heavy chain constant region not expressed or incorrectly expressed in the non-human mammal; and making one, two, three, four or more genes encoding an IgG heavy chain constant region in the non-human mammal not express or incorrectly express a CH1 domain during expression. The obtained non-human mammal or progeny thereof can be used for preparing a heavy chain antibody. The non-human mammal obtained by using the preparation method of the present application does not introduce any exogenous gene encoding heavy chain variable and constant regions of an antibody, and can directly use all VDJ genes encoding the heavy chain variable region of the antibody in its own genome, so as to produce more diverse heavy chain antibodies.

Abstract: An intelligent control gas suction-type electric propulsion system applicable to multi-flow regimes: an ultra-low orbit rare gas is used as a working medium for attitude orbit control and resistance compensation propulsion, the gas is collected and inputted into an intelligent feedback pressurization system by means of a parabolic gas intake duct, intelligent feedback and pressurization are performed on the gas working medium by a molecular pump and a gas pump and the medium is stored in a working fluid storage tank so as to supply a hybrid thruster system that consists of seven sets of electric thrusters to generate thrust, which may achieve multiple thrust modes, and achieve the purpose of attitude orbit control and resistance compensation.

Abstract: Provided are engineered transposable elements, gene transfer systems comprising the engineered transposable elements, as well as methods and kits for using the same. The compositions, systems, and methods are useful for inserting a heterologous nucleic acid into a target nucleic acid in vitro or in a cell.

Abstract: The invention described herein provides compositions and reagents for assembling a tripartite complex at a specific location of a target DNA. The invention also provides methods for using the complex to, for example, label a specific genomic locus, to regulate the expression of a target gene, or to create a gene regulatory network.

Abstract: The invention described herein provides compositions and reagents for assembling a tripartite complex at a specific location of a target DNA. The invention also provides methods for using the complex to, for example, label a specific genomic locus, to regulate the expression of a target gene, or to create a gene regulatory network.

Abstract: An intelligent control gas suction-type electric propulsion system applicable to multi-flow regimes: an ultra-low orbit rare gas is used as a working medium for attitude orbit control and resistance compensation propulsion, the gas is collected and inputted into an intelligent feedback pressurization system by means of a parabolic gas intake duct, intelligent feedback and pressurization are performed on the gas working medium by a molecular pump and a gas pump and the medium is stored in a working fluid storage tank so as to supply a hybrid thruster system that consists of seven sets of electric thrusters to generate thrust, which may achieve multiple thrust modes, and achieve the purpose of attitude orbit control and resistance compensation.

Abstract: The present invention relates to the field of gene editing and tumor immunotherapy. In particular, the invention relates to methods for preparing modified T cells, such as CAR-T cells, by gene editing, and modified T cells prepared by the methods and uses thereof.

Abstract: The invention described herein provides high throughput methods and reagents for generating transgenic animals (e.g., non-human mammals) through introducing a CRISPR/Cas9 system comprising a Cas9 protein into gametes or preimplantation stage embryos (e.g., one-cell embryos or zygotes) via multiple cycles (e.g., 4-10 cycles) of electroporation, leading to genetically inheritable modification to the genome of the animal.

Abstract: The invention described herein provides compositions and reagents for assembling a tripartite complex at a specific location of a target DNA. The invention also provides methods for using the complex to, for example, label a specific genomic locus, to regulate the expression of a target gene, or to create a gene regulatory network.

Abstract: The invention described herein provides high throughput methods and reagents for generating transgenic animals (e.g., mammals) through introducing materials into gametes or preimplantation stage (e.g., one-cell embryo or zygotes) via electroporation, leading to genetically inheritable modification to the genome of the animal.

Abstract: The invention is directed to a method of mutating one or more target nucleic acid sequences in a stem cell or a zygote comprising introducing into the stem cell or zygote (i) ribonucleic acid (RNA) sequences that comprise a portion that is complementary to a portion of each of the target nucleic acid sequences and comprise a binding site for a CRISPR associated (Cas) protein; and a Cas nucleic acid sequence or a variant thereof that encodes a Cas protein having nuclease activity. The stem cell or zygote is maintained under conditions in which the target nucleic acid sequences are mutated in the stem cell or zygote. The invention is also directed to methods of producing a non human mammal carrying mutations and methods of modulating the expression and/or activity target nucleic acid sequences and cells or zygotes.