Abstract: The present invention provides a model for high-throughput screening of endocrine disruptors and a method for screening the same. In the present invention, primary structural alerts, secondary structural alerts and tertiary structural alerts of compounds are extracted according to a nuclear receptor, and then the primary structural alerts, the secondary structural alerts and the tertiary structural alerts form a nuclear receptor high-throughput screening model; hierarchical structural alert matching is carried out on target compounds through the nuclear receptor high-throughput screening model, and ligand-receptor binding mode analysis and semi-quantitative prediction of binding activity and disrupting activity are performed.

Abstract: An implantation system for a cochlear implant microelectrode with remote motion center control includes: an electrode implantation device including at least one pair of forceps, and a distal end part of the forceps is used as a remote motion center; a six-degree-of-freedom motion mechanism; an input unit, configured to input a surgical trajectory; and a control unit, configured to calculate, a displacement of the forceps in a first body coordinate system, an offset compensation of each motion execution unit at the front end at a corresponding degree of freedom in the first body coordinate system, and an offset compensation of each motion execution unit at the rear end at a corresponding degree of freedom in a second body coordinate system, and drive, based on the corresponding offset compensation and a preset motion priority, the forceps and the corresponding motion execution unit to act.

Abstract: The present invention provides a model for high-throughput screening of endocrine disruptors and a method for screening the same. In the present invention, primary structural alerts, secondary structural alerts and tertiary structural alerts of compounds are extracted according to a nuclear receptor, and then the primary structural alerts, the secondary structural alerts and the tertiary structural alerts form a nuclear receptor high-throughput screening model; hierarchical structural alert matching is carried out on target compounds through the nuclear receptor high-throughput screening model, and ligand-receptor binding mode analysis and semi-quantitative prediction of binding activity and disrupting activity are performed.