Patents by Inventor Haozhen REN

Haozhen REN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bioartificial liver based on human iPSCs-derived hepatocyte-like cells and multilayer porous bioreactor
    Patent number: 11400199
    Abstract: A bioartificial liver (BAL) based on human induced pluripotent stem cells (iPSCs)-derived hepatocyte-like cells (HLCs) and a multilayer porous bioreactor is provided. The plasma separation/retransfusion loop part includes a blood input pipe, an exhaust pipe spring clamp, a blood input peristaltic pump, a heparin pump, a plasma separation column, a first pressure monitor, and a heater. The cell reactor/plasma component exchange double-loop part includes a plasma input peristaltic pump, and a semipermeable membrane exchange column, a plasma exchange peristaltic pump, a red blood cell (RBC) pool, a membrane lung, a multilayer porous bioreactor, a second pressure monitor, and a third pressure monitor arranged in a 37° C. dedicated incubator. An outlet of the third pressure monitor and a blood cell outlet are connected to an inlet of the first pressure monitor, and then connected to the heater and a blood output pipe in sequence.
    Type: Grant
    Filed: February 7, 2021
    Date of Patent: August 2, 2022
    Assignee: NANJING DRUM TOWER HOSPITAL
    Inventors: Jinglin Wang, Haozhen Ren, Yitao Ding, Xiaolei Shi
  • BIOARTIFICIAL LIVER BASED ON HUMAN iPSCs-DERIVED HEPATOCYTE-LIKE CELLS AND MULTILAYER POROUS BIOREACTOR
    Publication number: 20220143293
    Abstract: A bioartificial liver (BAL) based on human induced pluripotent stem cells (iPSCs)-derived hepatocyte-like cells (HLCs) and a multilayer porous bioreactor is provided. The plasma separation/retransfusion loop part includes a blood input pipe, an exhaust pipe spring clamp, a blood input peristaltic pump, a heparin pump, a plasma separation column, a first pressure monitor, and a heater. The cell reactor/plasma component exchange double-loop part includes a plasma input peristaltic pump, and a semipermeable membrane exchange column, a plasma exchange peristaltic pump, a red blood cell (RBC) pool, a membrane lung, a multilayer porous bioreactor, a second pressure monitor, and a third pressure monitor arranged in a 37° C. dedicated incubator. An outlet of the third pressure monitor and a blood cell outlet are connected to an inlet of the first pressure monitor, and then connected to the heater and a blood output pipe in sequence.
    Type: Application
    Filed: February 7, 2021
    Publication date: May 12, 2022
    Applicant: Nanjing Drum Tower Hospital
    Inventors: Xiaolei SHI, Haozhen REN, Jinglin WANG, Yitao DING