Patents by Inventor Harald Debelak

Harald Debelak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CpG oligonucleotide analogs containing hydrophobic T analogs with enhanced immunostimulatory activity
    Patent number: 10260071
    Abstract: The invention relates to oligonucleotides including at least one lipophilic substituted nucleotide analog and a pyrimidine-purine dinucleotide. The invention also relates to pharmaceutical compositions and methods of use thereof.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: April 16, 2019
    Assignee: COLEY PHARMACEUTICAL GMBH
    Inventors: Harald Debelak, Eugen Uhlmann, Marion Jurk
  • CpG Oligonucleotide Analogs Containing Hydrophobic T Analogs with Enhanced Immunostimulatory Activity
    Publication number: 20160348115
    Abstract: The invention relates to oligonucleotides including at least one lipophilic substituted nucleotide analog and a pyrimidine-purine dinucleotide. The invention also relates to pharmaceutical compositions and methods of use thereof.
    Type: Application
    Filed: May 26, 2016
    Publication date: December 1, 2016
    Inventors: Harald Debelak, Eugen Uhlmann, Marion Jurk
  • CpG oligonucleotide analogs containing hydrophobic T analogs with enhanced immunostimulatory activity
    Patent number: 9382545
    Abstract: The invention relates to oligonucleotides including at least one lipophilic substituted nucleotide analog and a pyrimidine-purine dinucleotide. The invention also relates to pharmaceutical compositions and methods of use thereof.
    Type: Grant
    Filed: October 4, 2013
    Date of Patent: July 5, 2016
    Assignee: COLEY PHARMACEUTICAL GMBH
    Inventors: Harald Debelak, Eugen Uhlmann, Marion Jurk
  • Immune stimulatory oligonucleotide analogs containing modified sugar moieties
    Patent number: 9186399
    Abstract: The invention relates to oligonucleotides including at least one FANA substituted nucleotide analog and a pyrimidine-purine dinucleotide. The invention also relates to pharmaceutical compositions and methods of use thereof.
    Type: Grant
    Filed: September 29, 2008
    Date of Patent: November 17, 2015
    Assignee: AdiutTide Pharmaceuticals GmbH
    Inventors: Eugen Uhlmann, Harald Debelak, Marion Jurk, Markus Weber
  • Immune stimulatory oligoribonucleotide analogs containing modified oligophosphate moieties
    Patent number: 9156875
    Abstract: Immunostimulatory oligoribonucleotides (ORN) featuring 5?-triphosphates and various 5?-triphosphate analogs are provided. Also provided are physiologically acceptable salts of the immunostimulatory ORN and pharmaceutical compositions containing the immunostimulatory ORN of the invention. ORN of the invention are useful as adjuvants and can be combined with an antigen to promote an antigen-specific immune response. ORN of the invention are also particularly useful for promoting a Th1-type immune response. Also provided are methods of use of the compounds and pharmaceutical compositions of the invention to enhance an immune response in a subject, as well to treat a number of conditions including cancer, infection, allergy, and asthma, and to vaccinate a subject against an antigen.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: October 13, 2015
    Assignee: AdiuTide Pharmaceuticals GmbH
    Inventors: Harald Debelak, Eugen Uhlmann
  • CpG Oligonucleotide Analogs Containing Hydrophobic T Analogs with Enhanced Immunostimulatory Activity
    Publication number: 20140163213
    Abstract: The invention relates to oligonucleotides including at least one lipophilic substituted nucleotide analog and a pyrimidine-purine dinucleotide. The invention also relates to pharmaceutical compositions and methods of use thereof.
    Type: Application
    Filed: October 4, 2013
    Publication date: June 12, 2014
    Applicant: COLEY PHARMACEUTICAL GMBH
    Inventors: Harald Debelak, Eugen Uhlmann, Marion Jurk
  • CpG oligonucleotide analogs containing hydrophobic T analogs with enhanced immunostimulatory activity
    Patent number: 8580268
    Abstract: The invention relates to oligonucleotides including at least one lipophilic substituted nucleotide analog and a pyrimidine-purine dinucleotide. The invention also relates to pharmaceutical compositions and methods of use thereof.
    Type: Grant
    Filed: September 27, 2007
    Date of Patent: November 12, 2013
    Assignee: Coley Pharmaceutical GmbH
    Inventors: Harald Debelak, Eugen Uhlmann, Marion Jurk
  • Immune stimulatory oligoribonucleotide analogs containing modified oligophosphate moieties
    Patent number: 8349812
    Abstract: Immunostimulatory oligoribonucleotides (ORN) featuring 5?-triphosphates and various 5?-triphosphate analogs are provided. Also provided are physiologically acceptable salts of the immunostimulatory ORN and pharmaceutical compositions containing the immunostimulatory ORN of the invention. ORN of the invention are useful as adjuvants and can be combined with an antigen to promote an antigen-specific immune response. ORN of the invention are also particularly useful for promoting a Th1-type immune response. Also provided are methods of use of the compounds and pharmaceutical compositions of the invention to enhance an immune response in a subject, as well to treat a number of conditions including cancer, infection, allergy, and asthma, and to vaccinate a subject against an antigen.
    Type: Grant
    Filed: October 30, 2008
    Date of Patent: January 8, 2013
    Assignee: AdiuTide Pharmaceuticals GmbH
    Inventors: Harald Debelak, Eugen Uhlmann
  • IMMUNE STIMULATORY OLIGONUCLEOTIDE ANALOGS CONTAINING MODIFIED SUGAR MOIETIES
    Publication number: 20110098456
    Abstract: The invention relates to oligonucleotides including at least one FANA substituted nucleotide analog and a pyrimidine-purine dinucleotide. The invention also relates to pharmaceutical compositions and methods of use thereof.
    Type: Application
    Filed: September 9, 2008
    Publication date: April 28, 2011
    Inventors: Eugen Uhlmann, Harald Debelak, Marion Jurk, Markus Weber
  • Immune Stimulatory Oligoribonucleotide Analogs Containing Modified Oligophosphate Moieties
    Publication number: 20100260788
    Abstract: Immunostimulatory oligoribonucleotides (ORN) featuring 5?-triphosphates and various 5?-triphosphate analogs are provided. Also provided are physiologically acceptable salts of the immunostimulatory ORN and pharmaceutical compositions containing the immunostimulatory ORN of the invention. ORN of the invention are useful as adjuvants and can be combined with an antigen to promote an antigen-specific immune response. ORN of the invention are also particularly useful for promoting a Th1-type immune response. Also provided are methods of use of the compounds and pharmaceutical compositions of the invention to enhance an immune response in a subject, as well to treat a number of conditions including cancer, infection, allergy, and asthma, and to vaccinate a subject against an antigen.
    Type: Application
    Filed: October 30, 2008
    Publication date: October 14, 2010
    Applicant: Dr. Eugen Uhlmann
    Inventors: Harald Debelak, Eugen Uhlmann
  • Compositions of TLR ligands and antivirals
    Publication number: 20100189772
    Abstract: The invention relates to methods and products for the treatment of viral infection using a combination of anti-viral agents and TLR ligands. The invention also relates to screening assays, associated products, kits, and in vitro methods.
    Type: Application
    Filed: September 27, 2007
    Publication date: July 29, 2010
    Applicants: COLEY PHARMACEUTICAL GROUP, INC, COLEY PHARMACEUTICAL GMBH, COLEY PHARMACEUTICAL GROUP, LTD
    Inventors: Jorg Vollmer, Marion Jurk, Eugen Uhlmann, Harald Debelak, Robert L. Bratzler, Alain Vicari
  • CpG Oligonucleotide Analogs Containing Hydrophobic T Analogs with Enhanced Immunostimulatory Activity
    Publication number: 20100166780
    Abstract: The invention relates to oligonucleotides including at least one lipophilic substituted nucleotide analog and a pyrimidine-purine dinucleotide. The invention also relates to pharmaceutical compositions and methods of use thereof.
    Type: Application
    Filed: September 27, 2007
    Publication date: July 1, 2010
    Inventors: Harald Debelak, Eugen Uhlmann, Marion Jurk
  • N -and c -linked purine based and structurally related heterocycles as universal nucleosides used oligonucleotides hybridization
    Patent number: 7063945
    Abstract: The present invention is directed to a nucleic acid binding compound comprising N8- or C8-linked purine bases or structurally related heterocycles, a compound useful for the preparation of such compound, a binding product of this nucleic acid binding compound with a nucleic acid, a method for the determination of a nucleic acid using said compound, and several uses of 8-linked purine bases and structurally related heterocycles. Compounds according to the present invention have advantageous properties when used in hybridization methods.
    Type: Grant
    Filed: March 27, 2001
    Date of Patent: June 20, 2006
    Assignee: Roche Molecular Systems, Inc
    Inventors: Frank Seela, Harald Debelak, Frank Bergmann, Dieter Heindl, Herbert Von Der Eltz
  • N8-and c8-linked purine based and structurally related heterocycles as universal nucleosides used oligonucleotides hybridization
    Publication number: 20040171820
    Abstract: The present invention is directed to a nucleic acid binding compound comprising N8- or C8-linked purine bases or structurally related heterocycles, a compound useful for the preparation of such compound, a binding product of this nucleic acid binding compound with a nucleic acid, a method for the determination of a nucleic acid using said compound, and several uses of 8-linked purine bases and structurally related heterocycles. Compounds according to the present invention have advantageous properties when used in hybridization methods.
    Type: Application
    Filed: September 10, 2002
    Publication date: September 2, 2004
    Inventors: Frank Seela, Harald Debelak, Frank Bergmann, Dieter Heindl, Herbert Von Der Eltz