Abstract: Disclosed compounds of general formula (1) wherein L, Q1, Q2, X, Y, Ra, Rb, Rc, R1, R2, R3 and R4 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition with the above-mentioned properties.

Abstract: Disclosed are new dihydropteridinones of general formula (I) wherein the groups R1 to R5, Ra to Rc, W, Q1 and Q2 have the meanings given in the claims and specification, the isomers thereof and the use thereof for preparing a pharmaceutical composition for the treatment of diseases characterised by excessive or abnormal cell proliferation.

Abstract: The present invention comprises compounds of general formula (1) wherein A, X, Y, Z, Ra, Rb, Rc, R1, R2 and R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or anomalous cell proliferation, and the use thereof for preparing a pharmaceutical composition with the above-mentioned properties.

Abstract: An apparatus for determining the partial pressure of a gas dissolved in a fluid which includes a catheter consisting of a double bored coaxial catheter having an outer tube and a spaced coaxial inner tube, the outer tube being permeable to the gas being measured, together with a pump for delivering a continuous flow of a carrier fluid into the space between the inner tube and the outer tube. A measuring device is located downstream of the catheter for determining the partial pressure of the gas in the carrier fluid. A mass transfer unit receives the gas after the measuring device and is arranged to bring the partial pressure of the gas in the carrier fluid to a predetermined value.