Abstract: The present application relates to compounds of formula (I) wherein A represents oxygen, sulfur or —NH—, m is 0-2, and R1, R2, R3, R6 and R7 have the meanings given in the specification, to a process for their preparation, as well as to their use in the inhibition of cyclooxygenase II.

Abstract: Compounds of the formula (I) in which A is oxygen, sulphur or NH; B is a group of the formula (IIa) or (IIb); and the other variables have the meaning given in claim 1, may be used as inhibitors of the enzyme cyclooxygenase II ##STR1##

Abstract: The invention relates to new piperazinylalkyl-3(2H)-pyridazinones of the formula ##STR1## in which the radicals R.sub.1 represents hydrogen, phenyl, benzyl, or (C.sub.1 -C.sub.6)-alkyl which is unsubstituted or substituted one or more times by hydroxyl, piperidine, morpholine or by a group NR.sub.4 R.sub.5 in which R.sub.4 and R.sub.5 can be identical or different and which represent hydrogen, methyl or ethyl,R.sub.2 and R.sub.3 represent hydrogen, halogen, (C.sub.1 -C.sub.6)-alkoxy or (C.sub.1 -C.sub.6)-alkyl, where at least one of the radicals R.sub.2 or R.sub.3 denotes hydrogen,R.sub.6 represents hydrogen, (C.sub.1 -C.sub.4)-alkyl, phenyl, benzyl or phenylethyl,B represents (C.sub.1 -C.sub.7)-alkylene which is unsubstituted or substituted one or more times by hydroxyl, (C.sub.1 -C.sub.4)-alkyl or by the group NR.sub.4 R.sub.5 and which can optionally be closed to form an alicyclic 4- to 7-membered ring,R.sub.8 and R.sub.9, which can be identical or different, represent hydrogen or (C.sub.1 -C.sub.