Abstract: A method for investigating biological cells or cell cultures in a microplate reader receives at least one microplate with wells containing biological cells or cell cultures by a receiving device; positions the wells with respect to measuring devices of the microplate reader and detects integral measurement signals by at least one of the measuring devices. The biological cells or cell cultures in the specific wells of the microplate(s) are transilluminated by an illumination source of the microplate reader and imaged by an imaging camera. Each of the detected integral signals is compared with the image of the biological cells or cell cultures in the corresponding wells of the microplate(s) by a processor and is related to the imaged number, adherence, confluence or morphology of these biological cells or cell cultures.

Abstract: A closure element with at least one vent opening is a sealing plug that has a pin-shaped lower part with an underside. The at least one vent opening is formed by a duct in the sealing plug which, starting at an inlet opening into the duct, extends upwards from the underside of the pin-shaped lower part in the interior of the sealing plug and leads out of the sealing plug through a lateral outlet opening. A method is also disclosed for the complete and bubble-free filling of a container with a closure element and to the use of a filled container provided with a closure.

Abstract: A microplate reader comprises a housing; at least one optical measuring/detection device; a microplate support; a moving unit; and an integrated lid holding apparatus. The lid holding apparatus is arranged to move the microplate lid and/or the microplate support is arranged to move the microplate in one respective, in an at least approximately vertical direction for moving the microplate lid away from the microplate. The lid holding apparatus is arranged inside the housing as a magnetic lifter and comprises a non-array arrangement of at least one permanent magnet, or at least three electromagnets, or at least one switchable permanent magnet. Each microplate lid to be moved away from the microplate comprises magnetizable material.

Abstract: Microplate reader has measuring space, action source, measuring device for biological structure signals of microplate wells, transport support for positioning wells in relation to an optical axis of the device and controller for the action source, the measuring device and the transport support. An incubation apparatus with a frame accommodates a microplate with wells having bottoms for reducing liquid evaporation. The frame has a first opening surrounded by an inner wall for the microplate and an outer wall parallel to the inner wall and connected thereto by an intermediate bottom so that a channel is formed and the intermediate bottom for accommodating a liquid adjusted to the content of the microplate wells. The incubation apparatus has a support surface with a second opening for a microplate and, as a result, at least a portion of the well bottoms is freely accessible by the second opening.

Abstract: Microplate reader has a housing, at least one optical measuring/detection device, a microplate support, a moving unit and an integrated lid holding apparatus. The lid holding apparatus moves the microplate in one respective, at least approximately vertical direction for moving the microplate lid away from the microplate. The lid holding apparatus is arranged inside the housing as a magnetic lifter and comprises a non-array arrangement of at least one permanent magnet, or at least three electro magnets, or at least one switchable permanent magnet. Each microplate lid to be moved away from the microplate comprises magnetizable material with a physical area. A projected area of the at least one permanent magnet, electro magnet, or switchable permanent magnet is smaller than the physical area of the magnetizable material of the microplate lid.

Abstract: Microplate reader has measuring space, action source, measuring device for biological structure signals of microplate wells, transport support for positioning wells in relation to an optical axis of the device and controller for the action source, the measuring device and the transport support. An incubation apparatus with a frame accommodates a microplate with wells having bottoms for reducing liquid evaporation. The frame has a first opening surrounded by an inner wall for the microplate and an outer wall parallel to the inner wall and connected thereto by an intermediate bottom so that a channel is formed and the intermediate bottom for accommodating a liquid adjusted to the content of the microplate wells. The incubation apparatus has a support surface with a second opening for a microplate and, as a result, at least a portion of the well bottoms is freely accessible by the second opening.

Abstract: Microplate reader has a housing, at least one optical measuring/detection device, a microplate support, a moving unit and an integrated lid holding apparatus. The lid holding apparatus moves the microplate in one respective, at least approximately vertical direction for moving the microplate lid away from the microplate. The lid holding apparatus is arranged inside the housing as a magnetic lifter and comprises a non-array arrangement of at least one permanent magnet, or at least three electro magnets, or at least one switchable permanent magnet. Each microplate lid to be moved away from the microplate comprises magnetizable material with a physical area. A projected area of the at least one permanent magnet, electro magnet, or switchable permanent magnet is smaller than the physical area of the magnetizable material of the microplate lid.

Abstract: A microplate reader (1) comprises a housing (3); at least one optical measuring/detection device (2); a microplate support (4); a moving unit (5); and an integrated lid holding apparatus (6). The lid holding apparatus (6) is arranged to move the microplate lid (7) and/or the microplate support (4) is arranged to move the microplate (8) in one respective, at least approximately vertical direction for moving the microplate lid (7) away from the microplate (8). The lid holding apparatus (6) is arranged inside the housing (3) as a magnetic lifter (6?) and comprises a non-array arrangement of at least one permanent magnet (9?), or at least three electro magnets (10?), or at least one switchable permanent magnet (11). Each microplate lid (7) to be moved away from the microplate (8) comprises magnetizable material (12).

Abstract: Microplate reader with optical measuring/detection device has housing, a microplate support and a moving unit. The moving unit moves the microplate support out and into the housing and horizontally within the housing. The reader has an integrated lid holding apparatus within the housing for lifting and placing a microplate lid on the microplate. The lid holding apparatus moves the microplate lid and/or the microplate support for moving the microplate in one respective vertical direction. A method for optically measuring a microplate in such a microplate reader places a covered microplate on the microplate support, retracts it into the housing, lifts the lid from the microplate, measures the microplate with the lifted lid, replaces the lid, and extends the support and the covered microplate out of the housing.

Abstract: Microplate reader with optical measuring/detection device has housing, a microplate support and a moving unit. The moving unit moves the microplate support out and into the housing and horizontally within the housing. The reader has an integrated lid holding apparatus within the housing for lifting and placing a microplate lid on the microplate. The lid holding apparatus moves the microplate lid and/or the microplate support for moving the microplate in one respective vertical direction. A method for optically measuring a microplate in such a microplate reader places a covered microplate on the microplate support, retracts it into the housing, lifts the lid from the microplate, measures the microplate with the lifted lid, replaces the lid, and extends the support and the covered microplate out of the housing.

Abstract: A method for investigating biological cells or cell cultures in a microplate reader receives at least one microplate with wells containing biological cells or cell cultures by a receiving device; positions the wells with respect to measuring devices of the microplate reader and detects integral measurement signals by at least one of the measuring devices. The biological cells or cell cultures in the specific wells of the microplate(s) are transilluminated by an illumination source of the microplate reader and imaged by an imaging camera. Each of the detected integral signals is compared with the image of the biological cells or cell cultures in the corresponding wells of the microplate(s) by a processor and is related to the imaged number, adherence, confluence or morphology of these biological cells or cell cultures.

Abstract: A slide transfer mechanism for a laser scanner device for imaging and measuring fluorescent samples is located in a sample plane on sample slides. The device includes a first optical system for providing laser beams and at least one detector for detecting an emission beam bundle coming from the sample, and a second optical system for forwarding the emission beam bundle to the at least one detector. The slide transfer mechanism has a motorized transport device for transferring a sample slide to the sample table and back. The storage unit of the laser scanner device includes a positioning plate for mounting a sample part magazine that has an open insertion side for storing sample slides in specific depositories. At a corner opposite to the insertion side, the sample part magazine includes a check opening for monitoring the presence or absence of a sample slide in a specific depository.

Abstract: A laser scanner device (1) for imaging and/or measuring fluorescent samples located on slides and treated using fluorescent pigments includes a sample table (2) defining a sample plane (49) and a motorized transport device (3) for moving a slide from a storage unit (4) to the sample table (2) and back. The storage unit (4) includes one sample part (7) for sample slides (8) and one test part (9) for test slides (10), each having at least one depository (6) and being accessible during the operation of the laser scanner device (1) for the transport device (3). The test part (9) is implemented separately from the sample part (7) and as a test part magazine (9?) that is permanently connected to the laser scanner device (1) for one or more test slides (10).

Abstract: Laser scanner and method images or measures fluorescent samples on specimen slides treated with different fluorescent dyes. Motor-driveable sample table for the slides includes a laser and first optical system creating two laser beams of differing wavelength, a scanner with movable head and an optical deflection element for deflecting the beams toward the sample. Scanner has second optical system for forwarding emission beam bundles to two detectors for detecting emission beam bundles coming from the samples. A drive and counter oscillator connected to the drive by connecting rods drives the head for rapid back-and-forth movement and the counter oscillator has a mass at least equivalent to the head for compensation by opposite movement to the head. The optical deflection element causes spatial separation of two resulting focal points and a spatial separation of the two beam bundles in the direction of the detectors.

Abstract: A slide transfer mechanism for a laser scanner device (1) is proposed. The laser scanner device (1) is configured for imaging and/or measuring fluorescent samples which are located in a sample plane (49) on sample slides (8). The laser scanner device (1) comprises a motor-drivable sample table (2) for holding a sample slide (8); a first optical system (53) for providing at least one laser beam (54); a scanner apparatus (72) for deflecting the laser beam (54) toward the sample, wherein the scanner head (50) is configured to be moveable back and forth in a direction of a scanning axis or X axis of a coordinate system. The laser scanner device (1) also comprises at least one detector (61) for detecting an emission beam bundle (59) coming from the sample and a second optical system (58) for forwarding the emission beam bundle (59) to the at least one detector (61).

Abstract: The invention relates to a laser scanner apparatus (1) for imaging and/or measuring fluorescent samples which are located on specimen slides (8) and treated with two different fluorescent dyes and also to a corresponding method. This laser scanner apparatus (1) comprises a motor-driveable sample table (2) with a receptacle (34) for specimen slides (8) in a sample plane (49); at least one laser (51,52) and a first optical system (53) for providing two laser beams (54,55) of differing wavelength; a scanner means (72) comprising a scanner head (50) which can move in a direction of movement (75) and has an optical deflection element (56) for deflecting the laser beams (54,55) toward the sample; and a first objective (57) for focusing the laser beams (54,55) on the sample in the plane (49).

Abstract: A laser scanner apparatus images and/or measures a fluorescent sample on a moveable table. At least one laser and an optical system provide two laser beams at differing wavelengths parallel to the fluorescent sample. A moveable wedge-shaped dichroic mirror deflects the laser beams through an objective toward the sample causing spatial separation of the focal points and two non-parallel emission beams. The emission beams are guided through an optical system to two detectors.

Abstract: Microplate reader (21) with a computer for controlling the components of said microplate reader (21), comprising a light source (15) for emitting light for irradiating samples (22) or transmitting light through samples (22), and a filter slide (1) situated in the excitation or detection beam path. The microplate reader (21) in accordance with the invention is characterized in that said filter slide (1) comprises an electronic memory (4) for recording and/or retrieving filter-specific data, with said filter-specific data comprising the number and intensity of the light flashes impinging upon a certain filter (2) of said filter slide (1) and/or the intensity and duration of all exposures performed, and that said filter slide (1) comprises a contact point (5,7) jointly with the microplate reader (21) for transmitting such filter-specific data from the computer to the electronic memory (4) of the filter slide (1) and for retrieving such filter-specific data with the computer.

Abstract: The invention relates to a laser scanner apparatus (1) for imaging and/or measuring fluorescent samples which are located on specimen slides (8) and treated with two different fluorescent dyes and also to a corresponding method. This laser scanner apparatus (1) comprises a motor-drivable sample table (2) with a receptacle (34) for specimen slides (8) in a sample plane (49); at least one laser (51,52) and a first optical system (53) for providing two laser beams (54,55) of differing wavelength oriented parallel to each other and extending parallel to this plane (49); a scanner means (72) comprising a scanner head (50) which can move back and forth parallel to this plane (49) and in a direction of movement (75) and has an optical deflection element (56) for deflecting the laser beams (54,55) toward the sample; and a first objective (57) for focusing the laser beams (54,55) on the sample in the plane (49).

Abstract: Relates to a laser scanner device (1) for imaging and/or measuring fluorescent samples located on slides and treated using fluorescent pigments. Such a device comprises a sample table (2) defining a sample plane (49) and a motorized transport device (3) for moving a slide from a storage unit (4) to the sample table (2) and back. The storage unit (4) comprises one sample part (7) for sample slides (8) and one test part (9) for test slides (10), each having at least one depository (6) and being accessible during the operation of the laser scanner device (1) for the transport device (3).