Patents by Inventor Harald Juppner

Harald Juppner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tip39 polypeptides
    Publication number: 20040176285
    Abstract: The invention relates to truncated TIP39 polypeptides and chimeric PTHrP/TIP polypeptides. The polypeptides are used as agonists or antagonists of PTH receptors in various medical conditions.
    Type: Application
    Filed: February 17, 2004
    Publication date: September 9, 2004
    Inventors: Harald Juppner, Thomas J Gardella, Kenneth P Jonsson, Markus R John, Robert C Gensure
  • Pth analogs for renal osteodystrophy and related uses
    Publication number: 20040014150
    Abstract: The invention relates to a mammalian cell lacking type-1 parathyroid hormone (PTH)/parathyroid hormone-related peptide(PTHrP)) receptor(PTH1R) activity and containing carboxyl-terminal parathyroid hormone receptor (CPTHR) activity. The invention also relates to a method of screening of agonists for antagonists for CPTHR.
    Type: Application
    Filed: July 8, 2003
    Publication date: January 22, 2004
    Inventors: F. Richard Bringhurst, Paola Divieti, Harald Juppner
  • Bioactive peptides and peptide derivatives of parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP)
    Publication number: 20030166838
    Abstract: Novel parathyroid hormone peptide (PTH) and parathyroid hormone related peptide (PTHrP) or derivatives thereof which are biologically active are disclosed, as are pharmaceutical compositions containing said peptides, and synthetic and recombinant methods for producing said peptides. Also disclosed are methods for treating mammalian conditions characterized by decreases in bone mass using therapeutically effective pharmaceutical compositions containing said peptides. Also disclosed are methods for screening candidate compounds of the invention for antagonistic or agonistic effects on parathyroid hormone receptor action. Also disclosed are diagnostic and therapeutic methods of said compounds.
    Type: Application
    Filed: July 11, 2002
    Publication date: September 4, 2003
    Inventors: Thomas J. Gardella, Henry M. Kronenberg, John T. Potts, Harald Juppner
  • PTH1R and PTH3R receptors, methods and uses thereof
    Publication number: 20030162256
    Abstract: The present invention relates to novel parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrP) receptors (PTH1R and PTH3R) isolated from zebrafish. The receptors of the present invention share homology with previously identified parathyroid hormone (PTH)/parathyroid related protein (PTHrP) receptors. Isolated nucleic acid molecules are provided encoding the zebrafish PTH1R and PTH3R receptors. PTH1R and PTH3R receptor polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of PTH1R and PTH3R receptor activity and to diagnostic and therapeutic methods.
    Type: Application
    Filed: February 25, 2003
    Publication date: August 28, 2003
    Applicant: The Massachusetts General Hospital
    Inventors: Harald Juppner, David A. Rubin
  • Parathyroid hormone receptor and DNA encoding same
    Publication number: 20030153041
    Abstract: DNA encoding a parathyroid hormone receptor; production and isolation of recombinant and synthetic parathyroid hormone receptor polypeptides and fragments; antibodies to parathyroid hormone receptors and receptor fragments; methods for screening candidate compounds for antagonistic or agonistic effects on parathyroid hormone receptor action; and diagnostic and therapeutic methods of these compounds are disclosed.
    Type: Application
    Filed: October 9, 2002
    Publication date: August 14, 2003
    Applicant: The General Hospital Corporation, a Massachusetts corporation
    Inventors: Gino V. Segre, Henry M. Kronenberg, Abdul-Badi Abou-Samra, Harald Juppner, John T. Potts, Ernestina Schipani
  • Nucleic acid encoding PTH1R receptor
    Patent number: 6541220
    Abstract: The present invention relates to novel parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrP) receptors (PTH1R and PTH3R) isolated from zebrafish. The receptors of the present invention share homology with previously identified parathyroid hormone (PTH)/parathyroid related protein (PTHrP) receptors. Isolated nucleic acid molecules are provided encoding the zebrafish PTH1R and PTH3R receptors. PTH1R and PTH3R receptor polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of PTH1R and PTH3R receptor activity and to diagnostic and therapeutic methods.
    Type: Grant
    Filed: November 30, 1999
    Date of Patent: April 1, 2003
    Assignee: The General Hospital Corporation
    Inventors: Harald Jüppner, David A. Rubin
  • Bioactive peptides and peptide derivatives of parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP)
    Patent number: 6495662
    Abstract: Novel parathyroid hormone peptide (PTH) and parathyroid hormone related peptide (PTHrP) or derivatives thereof which are biologically active are disclosed, as are pharmaceutical compositions containing said peptides, and synthetic and recombinant methods for producing said peptides. Also disclosed are methods for treating mammalian conditions characterized by decreases in bone mass using therapeutically effective pharmaceutical compositions containing said peptides. Also disclosed are methods for screening candidate compounds of the invention for antagonistic or agonistic effects on parathyroid hormone receptor action. Also disclosed are diagnostic and therapeutic methods of said compounds.
    Type: Grant
    Filed: October 20, 1999
    Date of Patent: December 17, 2002
    Assignee: The General Hospital Corporation
    Inventors: Thomas J. Gardella, Henry M. Kronenberg, John T. Potts, Jr., Harald Jüppner
  • Parathyroid hormone-related peptide analogs
    Patent number: 6362163
    Abstract: The present invention relates to novel PTHrP analogs that have been converted into potent PTH-2 receptor agonists or antagonists by the substitution of one or more amino acid residues of PTHrP to the corresponding residue(s) of PTH. A method of treating various disease states associated with altered function of the PTH-2 receptor, using these PTHrP analogs, is also described.
    Type: Grant
    Filed: August 9, 2000
    Date of Patent: March 26, 2002
    Assignee: The General Hospital Corporation
    Inventors: Thomas J. Gardella, Harald Jüppner
  • Parathyroid hormone-related peptide analogs
    Patent number: 6147186
    Abstract: The present invention relates to novel PTHrP analogs that have been converted into potent PTH-2 receptor agonists or antagonists by the substitution of one or more amino acid residues of PTHrP to the corresponding residue(s) of PTH. A method of treating various disease states associated with altered function of the PTH-2 receptor, using these PTHrP analogs, is also described.
    Type: Grant
    Filed: July 30, 1997
    Date of Patent: November 14, 2000
    Assignee: The General Hospital Corporation
    Inventors: Thomas J. Gardella, Harald Juppner
  • Parathyroid hormone receptor
    Patent number: 5886148
    Abstract: DNA encoding a parathyroid hormone receptor; production and isolation of recombinant and synthetic parathyroid hormone receptor polypeptides and fragments; antibodies to parathyroid hormone receptors and receptor fragments; methods for screening candidate compounds for antagonistic or agonistic effects on parathyroid hormone receptor action; and diagnostic and therapeutic methods of these compounds are disclosed.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: March 23, 1999
    Assignee: The General Hospital Corporation
    Inventors: Gino V. Segre, Henry M. Kronenberg, Abdul-Badi Abou-Samra, Harald Juppner, John T. Potts, Jr., Ernestina Schipani
  • Parathyroid hormone receptor and DNA encoding same
    Patent number: 5840853
    Abstract: DNA encoding a parathyroid hormone receptor; production and isolation of recombinant and synthetic parathyroid hormone receptor polypeptides and fragments; antibodies to parathyroid hormone receptors and receptor fragments; methods for screening candidate compounds for antagonistic or agonistic effects on parathyroid hormone receptor action; and diagnostic and therapeutic methods of these compounds are disclosed.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: November 24, 1998
    Assignee: The General Hospital Corporation
    Inventors: Gino V. Segre, Henry M. Kronenberg, Abdul-Badi Abou-Samra, Harald Juppner, John T. Potts, Jr., Ernestina Schipani
  • DNA and vectors encoding the parathyroid hormone receptor, transformed cells, and recombinant production of PTHR proteins and peptides
    Patent number: 5494806
    Abstract: DNA encoding a parathyroid hormone receptor; production and isolation of recombinant and synthetic parathyroid hormone receptor polypeptides and fragments; antibodies to parathyroid hormone receptors and receptor fragments; methods for screening candidate compounds for antagonistic or agonistic effects on parathyroid hormone receptor action; and diagnostic and therapeutic methods of these compounds are disclosed.
    Type: Grant
    Filed: April 6, 1992
    Date of Patent: February 27, 1996
    Assignee: The General Hospital Corporation
    Inventors: Gino V. Segre, Henry M. Kronenberg, Abdul-Badi Abou-Samra, Harald Juppner, John T. Potts, Jr., Ernestina Schipani