Abstract: A method treats patient with treatment resistant depression, adjunct to standard antidepressant treatment or as monotherapy. These patients will be identified by non-response to at least one pharmacological antidepressant treatment with a sufficient dose and over a sufficient period of time. Further, one embodiment of the method includes a procedure to identify patients who would benefit from a combination of standard antidepressants with the described compounds from the start of the treatment in order to maximize the likelihood of response. Another embodiment of the method combines the described compounds with forms of Magnesium salts in order to overcome longer term tolerability issues with the compounds.

Abstract: A method treats patient with treatment resistant depression, adjunct to standard antidepressant treatment or as monotherapy. These patients will be identified by non-response to at least one pharmacological antidepressant treatment with a sufficient dose and over a sufficient period of time. Further, one embodiment of the method includes a procedure to identify patients who would benefit from a combination of standard antidepressants with the described compounds from the start of the treatment in order to maximize the likelihood of response. Another embodiment of the method combines the described compounds with forms of Magnesium salts in order to overcome longer term tolerability issues with the compounds.

Abstract: Methods for treating severe melancholic depression, comprising administering, to a subject, a preparation comprising EPA, or metabolite(s) thereof.

Abstract: The invention relates to the novel use of plants and plant extracts for treating schizophrenia. Said plants and plant extracts are selected from St John's wort, gingko, saffron and ginseng. The use of said substances occurs preferably in conjunction with conventional psychotherapeutic drugs, i.e. in the form of a preparation combining standard medicaments for treating schizophrenia for the simultaneous, separate or graduated use in case of schizophrenia. The invention also relates to methods for treating schizophrenia.