Patents by Inventor Harald Niegel

Harald Niegel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of oxazaphosphorine-2-amines
    Publication number: 20030109737
    Abstract: A process for the preparation of oxazaphosphorine-2-amines of the formula (I) described by the reaction scheme 1
    Type: Application
    Filed: January 8, 2003
    Publication date: June 12, 2003
    Inventors: Ulf Niemeyer, Harald Niegel, Bernhard Kutscher, Ion Neda
  • Process for the preparation of oxazaphosphorine-2-amines
    Publication number: 20010047103
    Abstract: A process for the preparation of oxazaphosphorine-2-amines of the formula (I) described by the reaction scheme 1
    Type: Application
    Filed: December 7, 2000
    Publication date: November 29, 2001
    Applicant: Asta Medica Aktiengesellschaft
    Inventors: Ulf Niemeyer, Harald Niegel, Bernhard Kutscher, Ion Neda
  • Process for the preparation of oxazaphosphorine-2-amines
    Patent number: 6187941
    Abstract: A process for the preparation of oxazaphosphorine-2-amines of the formula (I) described by the reaction scheme in which R1 is H, 2-bromoethyl, 2-chloroethyl, 2-hydroxyethyl, 2-mesyloxyethyl or 1-phenylethyl; R2 is H or 2-chloroethyl; R3 is H, 2-bromoethyl, 2-chloroethyl or 1-phenylethyl; and R4 is H; or R1 and R2, and also R3 and R4, together with the linked N atom, form an aziridide ring, where R1, R2 and R3 are not simultaneously H, and R1 and R3 are not simultaneously 1-phenylethyl; and Y, which is optionally present, is hydrogen chloride or hydrogen bromide. The reaction is carried out in a single vessel with phosphoryl chloride and an auxiliary base as an acid-binding agent with minimization of the effect of water and without isolation of an intermediate compound.
    Type: Grant
    Filed: September 8, 1998
    Date of Patent: February 13, 2001
    Assignee: Asta Medica Aktiengesellschaft
    Inventors: Ulf Niemeyer, Harald Niegel, Bernard Kutscher, Ion Neda