Abstract: Disclosed is a computer-implemented method for modelling human or animal patient tissue. The method includes: acquiring a stressed patient topography data set, the stressed patient topography data set describing a topography of at least one patient tissue surface under mechanical stress; determining an input data set; evaluating a statistic model for the input data set, thereby obtaining an output data set; determining, from the output data set, a relaxed patient topography data set. The statistic model includes a set of Gaussian Processes and is defined by a pre-determined model parameter set, the model parameter set including at least one Gaussian Process parameter for each Gaussian Process, and wherein the statistic model is independent from the patient tissue to be modelled. Disclosed is further a computerized device for carrying out such method. Disclosed are further a computer-implemented method and a computerized device for determining a parameter set.

Abstract: A patient-specific finite element model of the cornea is generated for the purposes of modeling a cornea for simulating tissue cuts in the cornea. A first group of tissue fibers, with main fibers that extend parallel to the surface of the cornea, is distributed in the finite element model in accordance with a first distribution function. Moreover, a second group of tissue fibers, with inclined cross-linked fibers that do not extend parallel to the surface of the cornea, is distributed in the finite element model in accordance with a second distribution function. Here, the second distribution function distributes the cross-linked fibers with a non-uniform weighting function over the depth of the cornea, from the outer surface of the cornea to the inner surface of the cornea.

Abstract: A patient-specific finite element model of the cornea is generated for the purposes of modeling a cornea for simulating tissue cuts in the cornea. A first group of tissue fibers, with main fibers that extend parallel to the surface of the cornea, is distributed in the finite element model in accordance with a first distribution function. Moreover, a second group of tissue fibers, with inclined cross-linked fibers that do not extend parallel to the surface of the cornea, is distributed in the finite element model in accordance with a second distribution function. Here, the second distribution function distributes the cross-linked fibers with a non-uniform weighting function over the depth of the cornea, from the outer surface of the cornea to the inner surface of the cornea.