Abstract: The invention relates to novel bispecific antigen binding molecules, comprising at least two antigen binding domains capable of specific binding to OX40 and a particular antigen binding domain capable of specific binding to Fibroblast Activation Protein (FAP), and to methods of producing these molecules and to methods of using the same.

Abstract: The present invention relates to the production of adeno-associated viral vectors in insect cells. The insect cells therefore comprise a first nucleotide sequence encoding the adeno-associated virus (AAV) capsid proteins, whereby the initiation codon for translation of the AAV VP1 capsid protein is an AUG. Upstream of the VP1 open reading frame an alternative out of frame start codon is placed such that translation initiation of the VP1 protein is modified, i.e. reduced, to allow production of VP1:VP2:VP3 in a good stoichiometry resulting in AAV with high potency.

Abstract: The present invention relates to novel high-value polycarbonate polyols, to processes for the production thereof, to polyisocyanate prepolymers obtainable therefrom and also polyurethane (PUR) and polyurethane urea elastomers which under particularly demanding applications show unique combinations of processing characteristics, hydrolysis and oxidation stability, mechanical and dynamic mechanical properties.

Abstract: The present invention relates to sealing elements for blowout preventers comprising a sealing interface region, and a second region, wherein said sealing interface region is formed of a first polymer and said second region is formed of a second polymer, the first and second polymers having different Shore A hardnesses, including sealing elements made of dual hardness polyurethane.

Abstract: The present invention relates to the production of adeno-associated viral vectors in insect cells. The insect cells therefore comprise a first nucleotide sequence encoding the adeno-associated virus (AAV) capsid proteins, whereby the initiation codon for translation of the AAV VP1 capsid protein is an AUG. Upstream of the VP1 open reading frame an alternative out of frame start codon is placed such that translation initiation of the VP1 protein is modified, i.e. reduced, to allow production of VP1:VP2:VP3 in a good stoichiometry resulting in AAV with high potency.

Abstract: A computer-implemented system, platform, method and computer program product for optimizing a data analytics fraud prediction/detection pipeline that includes a combination of a classical machine learned classifier model with a quantum machine learned model to optimize the performance of the fraud prevention model. The feature selection uses different feature maps: one determined by the classic classifier and the other determined by the quantum model implementation that exploits the entanglement quantum property. The quantum method can include a quantum support vector machine implementing a built feature forward algorithm that uses a quantum kernel estimate for feature mapping. This quantum model can be run on a quantum computer or quantum simulator that can run a quantum algorithm built for extracting feature importance.

Abstract: The present invention relates to sealing elements for blowout preventers comprising a sealing interface region, and a second region, wherein said sealing interface region is formed of a first polymer and said second region is formed of a second polymer, the first and second polymers having different Shore A hardnesses, including sealing elements made of dual hardness polyurethane.

Abstract: The present invention relates to the production of adeno-associated viral vectors in insect cells. The insect cells therefore comprise a first nucleotide sequence encoding the adeno-associated virus (AAV) capsid proteins, whereby the initiation codon for translation of the AAV VP1 capsid protein is a non-ATG, suboptimal initiation codon and wherein the coding sequence for one or more amino acid residues have been inserted between the suboptimal translation initiation codon and the codon encoding the amino acid residue that corresponds to the amino acid residue at position 2 of the wild type capsid amino acid sequence of which the first amino acid residue is alanine, glycine, valine, aspartic acid or glutamic acid.

Abstract: The present invention relates to the production of adeno-associated viral vectors in insect cells. The insect cells therefore comprise a first nucleotide sequence encoding the adeno-associated virus (AAV) capsid proteins, whereby the initiation codon for translation of the AAV VP1 capsid protein is a non-ATG, suboptimal initiation codon and wherein the coding sequence for one or more amino acid residues have been inserted between the suboptimal translation initiation codon and the codon encoding the amino acid residue that corresponds to the amino acid residue at position 2 of the wild type capsid amino acid sequence of which the first amino acid residue is alanine, glycine valine, aspartic acid or glutamic acid.

Abstract: The present invention relates to the production of adeno-associated viral vectors in insect cells. The insect cells therefore comprise a first nucleotide sequence encoding the adeno-associated virus (AAV) capsid proteins, whereby the initiation codon for translation of the AAV VP1 capsid protein is an AUG. Upstream of the VP1 open reading frame an alternative out of frame start codon is placed such that translation initiation of the VP1 protein is modified, i.e. reduced, to allow production of VP1:VP2:VP3 in a good stoichiometry resulting in AAV with high potency.

Abstract: This disclosure relates to blood flow reversal valves and related systems and methods. In certain aspects of the invention, a blood flow reversal valve includes a first member having a first passage and a second passage, and a second member having a first passage and a second passage. The first and second members are rotatably fixed relative to one another such that the first passage of the first member is aligned with the first passage of the second member and the second passage of the first member is aligned with the second passage of the second member. A flow directing element is disposed in the cavity and is moveable relative to the first and second members between a first position in which the first passage of the first member and the first passage of the second member are fluidly connected and a second position in which the first passage of the first member and the second passage of the second member are fluidly connected.

Abstract: This disclosure relates to methods of reversing blood flow using a blood flow reversal valve that includes a first member having a first passage and a second passage, and a second member having a first passage and a second passage. The first and second members are rotatably fixed relative to one another such that the first passage of the first member is aligned with the first passage of the second member and the second passage of the first member is aligned with the second passage of the second member. A flow directing element is disposed in the cavity and is moveable between a first position in which the first passage of the first member and the first passage of the second member are fluidly connected and a second position in which the first passage of the first member and the second passage of the second member are fluidly connected.

Abstract: A method for manufacturing a lining part (L), which is formed from a support part (10) and a decorative layer (20), the method having the steps of: moving together a first tool part (210) with a first shaping surface (210a), against which a support part (10) lies, and a second tool part (220) with a second shaping surface (220a), against which a decorative layer (20) lies, wherein a groove section (61) of the support part (10), forming a support part longitudinal groove (50), is situated in a tool depression which is constructed in the first shaping surface (210a), extending a positioner (250) mounted in the second tool part (220) into an extended position such that the positioner (250) positions an edge section (25) of the decorative layer (20) such that said edge section projects into a region (60) bounded by the support part longitudinal groove (50), extending a slider (270) adjacent to the extended positioner (250) such that an edge section of the slider (270) presses the edge section (25) of the decor

Abstract: The present invention relates to the production of adeno-associated viral vectors in insect cells. The insect cells therefore comprise a first nucleotide sequence encoding the adeno-associated virus (AAV) capsid proteins, whereby the initiation codon for translation of the AAV VP1 capsid protein is a non-ATG, suboptimal initiation codon and wherein the coding sequence for one or more amino acid residues have been inserted between the suboptimal translation initiation codon and the codon encoding the amino acid residue that corresponds to the amino acid residue at position 2 of the wild type capsid amino acid sequence of which the first amino acid residue is alanine, glycine valine, aspartic acid or glutamic acid.

Abstract: In the automated method according to the invention for monitoring cell culture growth, in particular bacterial growth, a receiving dish (24) with a nutrient medium (38) is provided onto and/or into which is applied a cell culture, in particular a sample of human or animal tissue, such as blood, to which bacteria have been added and which also contains one or a plurality of reagents, in particular antibiotics. A microscope (10) having a camera (18) and an image acquisition plane adapted to be moved along the optical axis (20) is provided, and the receiving dish (24) is brought into the microscope (10) for monitoring a potential growth of the cell culture in the nutrient medium (38).

Abstract: An abrasion resistant multilayer liner for metal substrates with exceptional resistance to delamination, corrosion and physical wear comprises an epoxy layer formed by curing a phenolic epoxy resin with a curative comprising an anhydride adhered or bonded to a surface of the metal substrate, and an elastomeric polyurethane layer adhered or bonded to the epoxy layer. Metal surfaces lined with the inventive liner meet standards established for transport of oil sands slurries.

Abstract: This disclosure relates to methods of reversing blood flow using a blood flow reversal valve that includes a first member having a first passage and a second passage, and a second member having a first passage and a second passage. The first and second members are rotatably fixed relative to one another such that the first passage of the first member is aligned with the first passage of the second member and the second passage of the first member is aligned with the second passage of the second member. A flow directing element is disposed in the cavity and is moveable relative to the first and second members between a first position in which the first passage of the first member and the first passage of the second member are fluidly connected and a second position in which the first passage of the first member and the second passage of the second member are fluidly connected.

Abstract: This disclosure relates to blood flow reversal valves and related systems and methods. In certain aspects of the invention, a blood flow reversal valve includes a first member having a first passage and a second passage, and a second member having a first passage and a second passage. The first and second members are rotatably fixed relative to one another such that the first passage of the first member is aligned with the first passage of the second member and the second passage of the first member is aligned with the second passage of the second member. A flow directing element is disposed in the cavity and is moveable relative to the first and second members between a first position in which the first passage of the first member and the first passage of the second member are fluidly connected and a second position in which the first passage of the first member and the second passage of the second member are fluidly connected.

Abstract: An arrangement and a method for venting gases from a container containing mixture of salt concentrate and fluid for use in dialysis, including venting the gases to a hydrochamber disposed upstream of the container.

Abstract: An inner lining part for the interior of a motor vehicle, wherein the inner lining part has a carrier part, which comprises a curvature section, with a curvature running along a longitudinal direction of the carrier part. The curvature section includes a carrier part groove running in the longitudinal direction. A decorative layer overlies a first surface of the carrier part and forms a visible face of the inner lining part. The decorative layer covers the carrier part groove, thereby forming a decorative layer groove on the visible face of the inner lining part. Recesses in one or more portions of the carrier part at the carrier part groove receive folds or thickenings of the decorative layer to thereby permit the visible face of the decorative layer at the decorative layer groove to match the curvature of the curvature section at carrier side regions located adjacent the groove.