Abstract: The application relates to a composition comprising a hyperbranched polymer attached to a core and a biologically active moiety. The biologically active moiety is attached to the core by means of a substantially non-enzymatically cleavable linker L. The composition can be used to deliver the biologically active moiety to its target.

Abstract: A polymeric prodrug composition including a hydrogel, a biologically active moiety and a reversible prodrug linker. The prodrug linker covalently links the hydrogel and the biologically active moiety at a position and the hydrogel has a plurality of pores with openings on its surface. The diameter of the pores is larger than that of the biologically active moiety at least at all points of the pore between at least one of the openings and the position of the biologically active moiety.

Abstract: The present invention relates to sensors for the detection of molecular interactions between immobilized ligands and non-immobilized interaction partners (receptors). These surfaces use novel ligand-anchor conjugates which allow highly specific interaction with suitable interaction partners. Furthermore the invention relates to methods of providing the sensing surface and in particular methods of synthesising the ligand-anchor conjugates (LAC).

Abstract: Disclosed is a method for the identification of active compounds interacting with a target molecule, comprising the steps of: (a) forming a binding matrix comprising at least two different ligands on a solid support by immobilising said ligands via a common intermediate molecule on the support; (b) contacting a target of interest with said binding matrix; (c) parallely determining a binding value of the ligand/target interaction for each type of ligand comprised in the binding matrix; (d) selecting those ligands the binding value of which in an immobilised state with the target exceeds a predetermined threshold; (e) replacing the common intermediate molecule by a replacing fragment in order to form new ligands of increased molecular weight, with the replacing fragment being coupled to the ligand(s) of step (d) at the common binding position between the ligand and the intermediate molecule; (f) determining the affinity of the ligands formed in step (e) towards the target.

Abstract: The present invention relates to binding surfaces for the immobilization of ligands, ligand surfaces and structured surface arrays which present a plurality of identical or different ligands. The invention further relates to a process for the production and the use of such surfaces and to specific binder molecules which can be used for the preparation thereof.

Abstract: The present invention relates to a synthesis apparatus, especially for use in combinatorial chemistry (e.g., solid phase synthesis) as well as a method of manufacturing the same. The synthesis apparatus according to the present invention comprises essentially a vessel, e.g., a microtiterplate, with wall and/or bottom sections as well as a solid phase support, e.g., membranes, which are suitable for use in solid phase synthesis. By thermal effects in an area, preferably a very limited area, of the solid phase support the support is fixed to at least one section of the vessel.

Abstract: A parallel high throughput screening method on a solid support is disclosed that allows the detection of low affinity binding partners, comprising the steps of:(a) providing a library of different ligands;(b) forming a binding matrix comprising the ligands on a solid support by immobilising said ligands on the support; (c) contacting a target of interest with said binding matrix; (d) parallely determining a binding value of the ligand/target interaction for each type of ligand comprised in the binding matrix; (e) selecting those ligands the binding value of which in an immobilised state towards the target exceeds a predetermined threshold; (f) evaluating the affinity of each of the ligands selected in step (e) in a non-immobilised state towards the target; (g) identifying at least one ligand of step (f) as low affinity binding ligand.

Abstract: The present invention relates to binding surfaces for the immobilization of ligands, ligand surfaces and structured surface arrays which present a plurality of identical or different ligands. The invention further relates to a process for the production and the use of such surfaces and to specific binder molecules which can be used for the preparation thereof.

Abstract: Process for the preparation of polyaspartic acid derivatives of the general formula (I) 1

Abstract: The present invention relates to sensors for the detection of molecular interactions between immobilized ligands and non-immobilized interaction partners (receptors). These surfaces use novel ligand-anchor conjugates which allow highly specific interaction with suitable interaction partners. Furthermore the invention relates to methods of providing the sensing surface and in particular methods of synthesising the ligand-anchor conjugates (LAC).

Abstract: Probabilities of usage of specific words are evaluated based on frequency of usage in the selected language, such as English. Syntax type probabilities of word sequencing are evaluated through (i) rules based on transitional probability of use of two particular words in sequence in English usage and (ii) rules based on probability of relative positioning of words of particular word categories (e.g., nouns and adjectives) in a sentence structure in English usage. A word trellis or lattice represents choice paths for alternative sentence structures. By selecting the path with the highest probability values, highly accurate sentence reconstruction is provided.

Abstract: Copolymers derived from polyamino acids with at least 75% of the units present selected from the group consisting of structural units having the general formulas (I) and (II) in which the structural elements A are identical or different trifunctional hydrocarbon radicals with 2 or 3 C atoms, wherein the copolymer contains at least three units of formula (I).

Abstract: Single stroke text entry via a telephone keypad is subject to ambiguities resulting from the overloading of three letters on one key. After text is entered the three letter per position code block represented by the key strokes for a word position is hashed to all matches in a stored dictionary type word list. The resulting word group of alternative word choices for that word position is subjected to probability analysis. Probabilities of usage of specific words are evaluated based on frequency of usage in the selected language, such as English. Syntax type probabilities of word sequencing are evaluated through (i) rules based on transitional probability of use of two particular words in sequence in English usage and (ii) rules based on probability of relative positioning of words of particular word categories (e.g., nouns and adjectives) in a sentence structure in English usage. A word trellis or lattice represents choice paths for alternative sentence structures.

Abstract: A preparation for the abhesive coating of baking tins, baking molds, frying pans, metal pots and the like is disclosed. The preparation which comprises predominantly a heat-curable, polyol-modified polysiloxane A and 0.05 to 4% by weight, based on polysiloxane A, of a linear siloxane B that is capable of reacting with polysiloxane A. The modified polysiloxane A is obtained by reaction of a polysiloxane A1 of the general formula. ##STR1## wherein OR.sup.1 is an alkoxy group, derived from a primary or scondary alcohol with 1 to 4 carbon atoms,R.sup.2 is alkyl and/or phenyl,a=1 to 1.5,b=0.1 to 0.08,with a multihydric alcohol A2, with the characteristic feature that, as multihydric alcohol A2, is used an ester group-containing polyo of the general formula ##STR2## which can be obtained by the esterification of 1 mole of dicarboxylic acid HOOC--R.sup.7 --COOH with 2 moles of alcohol of formula R.sup.6 OH, the R.sup.6 groups in the molecule being the same or different and representing the groups ##STR3## wherein R.

Abstract: A continuous process for the preparation of alkoxypolysiloxane in which silane or a silane mixture and a mixture of hydrogen chloride-containing alcohol and water is fed continuously into the lower region of preferably cylindrical stirred reactor, the reaction product formed together with excess hydrogen chloride-containing alcohol is drawn off continuously after residence time of 30 to 180 minutes at the upper end of the reactor and the undissolved, gaseous portion of hydrogen chloride is carried off at the head of the reactor, the temperature of the reaction mixture or the reaction product, as it flows through the reactor, being raised from a range of -17.degree. to +30.degree. C. to range of +30.degree. to +80.degree. C., the temperature gradient having to be at least 10.degree. C.

Abstract: Heat-curable vehicles and a process for their preparation which can be diluted with water after neutralization, by the partial reaction of a low molecular weight alkoxysiloxane with a low molecular weight polyol having carboxyl groups and at least two hydroxyl groups. The vehicle dissolves in water, optionally in the presence of slight amounts of auxiliary solvents, highly concentrated solutions being obtained with a solids content of 80 weight percent or higher, yet a relatively low viscosity.

Abstract: The invention relates to a process for heat-curable silicone resins and their synthesis by reacting a low molecular weight alkoxysilane with a low molecular weight polyol with 2 to 6 hydroxyl groups in the molecule. The reaction products have a very low viscosity, which is suitable for processing when about 20% of solvent, based on the non-volatile resin, are added.

Abstract: The invention relates to a process for the preparation of heat-curable resins, usable especially as electrically insulating resins, by the reaction of alkoxy siloxanes of the formula ##STR1## in which OR.sup.1 represents an alkoxy group of primary or secondary aliphatic alcohols with 1 to 4 carbon atoms,R.sup.2 represents an alkyl or a phenyl group,a has a value of 1.0 to 1.5,b has a value of 0.1 to 1.0; witha mixture of low molecular weight, multihydric alcohols consisting of(a) 25 to 95 mole percent of neopentylglycol hydroxypivalate, and(b) 75 to 5 mole percent of a low molecular weight, at least trihydric alcoholat temperatures of 80.degree. to 200.degree. C. The resins thus prepared can be utilized advantageously for the insulation of generators, transformers and the like. They possess high elasticity and excellent adhesion.

Abstract: A process for the preparation of aqueous solutions of alkali organosiliconates in which organoalkoxypolysiloxanes of the formula ##EQU1## in which R.sup.1 is an alkyl residue with 1 to 3 carbon atoms, a vinyl residue and/or a phenyl residue,R.sup.2 is an alkyl residue with 1 to 4 carbon atoms,a is a number .ltoreq.2, andx is 1 to 1.25,are reacted with aqueous solutions of sodium hydroxide or potassium hydroxide having a concentration of 0.7 to 0.9 mole/100 g at temperatures .gtoreq.80.degree. C. The liberated alcohol R.sup.2 OH may be distilled and/or the concentration adjusted to the desired value by the addition of water. With the present invention, alkali chloride-free alkali organosiliconate solutions having high concentration can be obtained while avoiding a filtration step.