Patents by Inventor Harbaksh Sidhu
Harbaksh Sidhu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9731219Abstract: A supercritical fluid chromatography system comprises a first pump for pumping a first flow stream comprising a compressible fluid and a second pump for pumping a second flow stream comprising a modifier fluid. The second pump is in parallel with the first pump. A column is located in a combined flow stream. The column is located downstream of the first and second pumps. The combined flow stream comprises the first flow stream, the second flow stream, and a sample. A detector is located downstream of the column. A gas-liquid separator is located downstream of the detector. The gas-liquid separator is configured to vent a majority of the compressible fluid while maintaining a majority of the sample, thus preventing aerosolization of the flow stream and minimizing sample loss as well as cross contamination. An open bed collector is located after the gas-liquid separator.Type: GrantFiled: June 15, 2012Date of Patent: August 15, 2017Assignee: Waters Technologies CorporationInventors: Ziqiang Wang, Steven L. Zulli, Daniel Rolle, Chuping Luo, Harbaksh Sidhu
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Patent number: 9205350Abstract: A collection system for collecting samples from a flowstream (5) exiting a supercritical fluid chromatography system is provided. The collection system comprises: (i) a first back pressure regulator (10) on the flowstream as it exits the chromatography system, (ii) a gas-liquid separator (30) having a tapered and angled dripper (65), which introduces the flow into the separator at an angle tangential to the separator wall; and (iii) one or more fraction collectors (15), wherein the fraction collector is at a reduced pressure collection point, between 100 bar and atmospheric pressure. A collection system for HPLC is also provided, as well as a process for collection of samples from a flowstream.Type: GrantFiled: November 12, 2009Date of Patent: December 8, 2015Assignee: Waters Technologies CorporationInventors: Harbaksh Sidhu, Ziqiang Wang, Steven L. Zulli
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Patent number: 9205351Abstract: A collection system for collecting samples from a flowstream (5) exiting a supercritical fluid chromatography system is provided. The collection system comprises: (i) a first back pressure regulator (10) on the flowstream as it exits the chromatography system, (ii) a gas-liquid separator (30) having a tapered and angled dripper (65), which introduces the flow into the separator at an angle tangential to the separator wall; and (iii) one or more fraction collectors (15), wherein the fraction collector is at a reduced pressure collection point, between 100 bar and atmospheric pressure. A collection system for HPLC is also provided, as well as a process for collection of samples from a flowstream.Type: GrantFiled: November 20, 2013Date of Patent: December 8, 2015Assignee: Waters Technologies CorporationInventors: Harbaksh Sidhu, Ziqiang Wang, Steven L. Zulli
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Publication number: 20140230528Abstract: A mixing device for use in a chromatography system, the device includes an exterior housing having a first end and a second end and a hydraulic flow connector at the first end of the exterior housing. A cartridge including a chamber is enclosed within the exterior housing. The chamber has at least one wall defining an interior volume having a shape, wherein the shape of the interior volume creates a turbulent flow condition to mix at least two fluids and provide flow through the cartridge during operation of the chromatography system. The chamber also retains the sample, thereby ensuring that the sample is focused in the chamber such that a more narrow bolus of sample enters the chromatography column.Type: ApplicationFiled: June 15, 2012Publication date: August 21, 2014Applicant: WATERS TECHNOLOGIES CORPORATIONInventors: Ziqiang Wang, Chuping Luo, Harbaksh Sidhu
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Publication number: 20140217031Abstract: A supercritical fluid chromatography system comprises a first pump for pumping a first flow stream comprising a compressible fluid and a second pump for pumping a second flow stream comprising a modifier fluid. The second pump is in parallel with the first pump. A column is located in a combined flow stream. The column is located downstream of the first and second pumps. The combined flow stream comprises the first flow stream, the second flow stream, and a sample. A detector is located downstream of the column. A gas-liquid separator is located downstream of the detector. The gas-liquid separator is configured to vent a majority of the compressible fluid while maintaining a majority of the sample, thus preventing aerosolization of the flow stream and minimizing sample loss as well as cross contamination. An open bed collector is located after the gas-liquid separator.Type: ApplicationFiled: June 15, 2012Publication date: August 7, 2014Applicant: Waters Technologies CorporationInventors: Ziqiang Wang, Steve Zulli, Daniel Rolle, Chuping Luo, Harbaksh Sidhu
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Publication number: 20140190890Abstract: A collection system for collecting samples from a flowstream (5) exiting a supercritical fluid chromatography system is provided. The collection system comprises: (i) a first back pressure regulator (10) on the flowstream as it exits the chromatography system, (ii) a gas-liquid separator (30) having a tapered and angled dripper (65), which introduces the flow into the separator at an angle tangential to the separator wall; and (iii) one or more fraction collectors (15), wherein the fraction collector is at a reduced pressure collection point, between 100 bar and atmospheric pressure. A collection system for HPLC is also provided, as well as a process for collection of samples from a flowstream.Type: ApplicationFiled: November 20, 2013Publication date: July 10, 2014Applicant: Waters Technologies CorporationInventors: Harbaksh Sidhu, Ziqiang Wang, Steven L. Zulli
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Publication number: 20130186831Abstract: A collection system for collecting samples from a flowstream (5) exiting a supercritical fluid chromatography system is provided. The collection system comprises: (i) a first back pressure regulator (10) on the flowstream as it exits the chromatography system, (ii) a gas-liquid separator (30) having a tapered and angled dripper (65), which introduces the flow into the separator at an angle tangential to the separator wall; and (iii) one or more fraction collectors (15), wherein the fraction collector is at a reduced pressure collection point, between 100 bar and atmospheric pressure. A collection system for HPLC is also provided, as well as a process for collection of samples from a flowstream.Type: ApplicationFiled: November 12, 2009Publication date: July 25, 2013Applicant: THAR INSTRUMENTS, INC.Inventors: Harbaksh Sidhu, Ziqiang Wang
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Patent number: 8246834Abstract: A method for separating a sample using high pressure flash chromatography is provided. The method comprises the steps of: i) providing a pressurized vessel containing an adsorption material; ii) pressurizing a compressible fluid, optionally containing a cosolvent, to create a mobile phase; iii) premixing the sample with the mobile phase or optionally placing the sample in the pressurized vessel; iv) eluting the mobile phase through the pressurized vessel, to obtain a separated sample; v) heating the mobile phase containing the separated sample after the mobile phase exits the pressurized vessel to remove the compressible fluid; and iv) collecting the separated sample. The pressurized vessel contains an adsorption material having a particle size of 10-100 microns, and the pressure of the adsorption vessel is held at 50-350 bar during elution. Also provided is an apparatus for carrying out the above method.Type: GrantFiled: January 26, 2011Date of Patent: August 21, 2012Assignee: Waters Technologies CorporationInventors: Lalit Chordia, Harbaksh Sidhu, Todd Palcic, John Whelan
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Publication number: 20110306146Abstract: The invention provides an apparatus for supercritical fluid chromatography. The apparatus comprises a binary pump; an autosampler; a sampling valve; a first and second port switching valve; a first and second manifold; two or more channels, each having a check valve assembly, a separation column and one or more detectors operatively connected thereon; and a backpressure regulator. The apparatus also includes computer software and hardware to control distribution of fluid through the apparatus, including switching between a multi-channel mode or a single channel ode; 2) analyze data collected by the one or more detectors; and 3) optimize separation of analytes by controlling solvent combinations, concentration gradients, pressure and temperature. The apparatus excludes additional backpressure regulators or pumps on individual channels.Type: ApplicationFiled: September 29, 2009Publication date: December 15, 2011Applicant: THAR INSTRUMENTS, INC.Inventors: Harbaksh Sidhu, Ziqiang Wang, Michael Webster
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Publication number: 20110180481Abstract: A method for separating a sample using high pressure flash chromatography is provided. The method comprises the steps of: i) providing a pressurized vessel containing an adsorption material; ii) pressurizing a compressible fluid, optionally containing a cosolvent, to create a mobile phase; iii) premixing the sample with the mobile phase or optionally placing the sample in the pressurized vessel; iv) eluting the mobile phase through the pressurized vessel, to obtain a separated sample; v) heating the mobile phase containing the separated sample after the mobile phase exits the pressurized vessel to remove the compressible fluid; and iv) collecting the separated sample. The pressurized vessel contains an adsorption material having a particle size of 10-100 microns, and the pressure of the adsorption vessel is held at 50-350 bar during elution. Also provided is an apparatus for carrying out the above method.Type: ApplicationFiled: January 26, 2011Publication date: July 28, 2011Applicant: THAR INSTRUMENTS, INC.Inventors: Lalit Chordia, Harbaksh Sidhu, Todd Palcic, John Whelan
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Publication number: 20080053908Abstract: A method for separating a sample using high pressure flash chromatography is provided. The method comprises the steps of: i) providing a pressurized vessel containing an adsorption material; ii) pressurizing a compressible fluid, optionally containing a cosolvent, to create a mobile phase; iii) premixing the sample with the mobile phase or optionally placing the sample in the pressurized vessel; iv) eluting the mobile phase through the pressurized vessel, to obtain a separated sample; v) heating the mobile phase containing the separated sample after the mobile phase exits the pressurized vessel to remove the compressible fluid; and iv) collecting the separated sample. The pressurized vessel contains an adsorption material having a particle size of 10-100 microns, and the pressure of the adsorption vessel is held at 50-350 bar during elution. Also provided is an apparatus for carrying out the above method.Type: ApplicationFiled: September 4, 2007Publication date: March 6, 2008Inventors: Lalit Chordia, Harbaksh Sidhu, Todd Palcic, John Whelan
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Publication number: 20060188397Abstract: The present invention provides a method and apparatus for fraction collection from a chromatographic system. One or more substances of interest from a sample are collected in high concentration with high efficiency.Type: ApplicationFiled: January 9, 2006Publication date: August 24, 2006Inventors: Lalit Chordia, Harbaksh Sidhu, Edward Bates
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Publication number: 20050258087Abstract: The present invention provides a method and device for collecting and concentrating a desired compound from a chromatographic column exit stream. The collection chamber can be heated or cooled and washed in a forward or backward direction for efficient removal.Type: ApplicationFiled: April 22, 2005Publication date: November 24, 2005Inventors: Lalit Chordia, Harbaksh Sidhu
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Patent number: 6908557Abstract: The present invention provides a method and device for collecting and concentrating a desired compound from a chromatographic column exit stream. The collection chamber can be heated or cooled and washed in a forward or backward direction for efficient removal.Type: GrantFiled: June 24, 2003Date of Patent: June 21, 2005Assignee: Thar Technologies, Inc.Inventors: Lalit Chordia, Harbaksh Sidhu
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Publication number: 20040262222Abstract: The present invention provides a method and device for collecting and concentrating a desired compound from a chromatographic column exit stream. The collection chamber can be heated or cooled and washed in a forward or backward direction for efficient removal.Type: ApplicationFiled: June 24, 2003Publication date: December 30, 2004Inventors: Lalit Chordia, Harbaksh Sidhu