Abstract: An ophthalmic diagnostic system, method and medium for determining the lens crystallin index includes: focused delivery of a coherent source to a measurement volume in the interior of the lens; a second focused delivery of a coherent source is combined with the first source for precise location of the measurement volume; a third coherent optical path collects the backward scattered signal from the random movement of crystallins within the lens; a power splitter obtains two copies of the backward scattered signal; cross/auto correlation of the backward scattered signal is performed and modulated over a time scale; and various time scale signatures are processed obtain the lens crystalline index. The system, method, and medium are self-correcting and account for abnormal counter values.

Abstract: Provided are an apparatus and method for hair removal. The apparatus includes a light source, a coherent imaging fiber, a plurality of multimode optical fibers that transmit energy from the light source, and an applicator housing each proximal end of each optical fiber of the plurality of multimode optical fibers, with the coherent imaging fiber transmitting an image of a hair follicle from among a plurality of hair follicles, for viewing on a display.

Abstract: A photoepilation device including a compact hand piece applicator and a portable electronics module for use in a non-medical setting. The hand piece, which contains no electrical signals, allows the user to focus on individual hair follicles by observing a magnified image provided on a semiconductor display. The image from the hand piece is transported to a remote CCD through a coherent imaging fiber. which also delivers the therapeutic energy pulse from a remotely located source to the localized target. Destruction of pluripotential follicular stems cells found in the hair bulb and bulge regions is possible via a single low power laser diode. Control of pulse width and spot size attains a range of fluence levels up to 85 J·cm?2.

Abstract: A method for fluorescence detection that provides control of experimental and molecular factors and reliably predicts of concentration from fluorescence intensity measurements utilizing capillary-based flow sensors utilizing a dual detector approach to provide instantaneous normalization of the fluorescent intensity by the Rayleigh scattered intensity measured from the same sensing volume, insensitive to various experimental parameters for prediction of absolute concentrations of fluorescent solutes.

Abstract: A photoepilation device including a compact hand piece applicator and a portable electronics module for use in a non-medical setting. The hand piece, which contains no electrical signals, allows the user to focus on individual hair follicles by observing a magnified image provided on a semiconductor display. The image from the hand piece is transported to a remote CCD through a coherent imaging fiber, which also delivers the therapeutic energy pulse from a remotely located source to the localized target. Destruction of pluripotential follicular stems cells found in the hair bulb and bulge regions is possible via a single low power laser diode. Control of pulse width and spot size attains a range of fluence levels up to 85 J·cm?2.

Abstract: A capillary waveguide fluorescence sensor which includes a capillary and an optical/fluid connector connected to an end of the capillary. The optical/fluid connector includes a fluid sample injection port for longitudinally injecting a fluid sample into the capillary bore and at least one optical fiber for either longitudinally delivering light energy into the capillary or longitudinally collecting fluorescence emission from the fluid sample injected into the capillary bore. The sensor may also include at least one capillary outer surface collection optical fiber for perpendicularly collecting fluorescence emission from the fluid sample injected into the capillary bore. The capillary outer surface collection optical fiber is positioned adjacent the outer surface of the capillary wall such that the central axis of the collection optical fiber is substantially perpendicular to the central axis of the capillary bore.

Abstract: A capillary waveguide fluorescence sensor which includes a capillary and an optical/fluid connector connected to an end of the capillary. The optical/fluid connector includes a fluid sample injection port for longitudinally injecting a fluid sample into the capillary bore and at least one optical fiber for either longitudinally delivering light energy into the capillary or longitudinally collecting fluorescence emission from the fluid sample injected into the capillary bore. The sensor may also include at least one capillary outer surface collection optical fiber for perpendicularly collecting fluorescence emission from the fluid sample injected into the capillary bore. The capillary outer surface collection optical fiber is positioned adjacent the outer surface of the capillary wall such that the central axis of the collection optical fiber is substantially perpendicular to the central axis of the capillary bore.

Abstract: An apparatus for determining the size or other physical properties of particles executing Brownian motion is provided. An integrated fiber optic probe, including a length of a gradient index multimode optical fiber fusion spliced to a monomode optical fiber, delivers laser light to a scattering medium such that the light scattered in the backward direction is collected by another integrated fiber optic probe mounted into the same cylindrical housing. A step index fiber may be fusion spliced between the monomode and gradient index multimode fibers. The axes of the fibers may be collinear or offset. The scattered light, after conversion to a series of photoelectron pulses, is processed to determine the mean particle diameter. The temporal coherence of the scattered field from submicroscopic particles illuminated by laser light is a function of both the integration time and the particle diameter.

Abstract: A system and method are disclosed for efficient laser illumination of the interiors of multiple capillaries simultaneously, and collection of light emitted from them. Capillaries in a parallel array can form an optical waveguide wherein refraction at the cylindrical surfaces confines side-on illuminating light to the core of each successive capillary in the array. Methods are provided for determining conditions where capillaries will form a waveguide and for assessing and minimizing losses due to reflection. Light can be delivered to the arrayed capillaries through an integrated fiber optic transmitter or through a pair of such transmitters aligned coaxially at opposite sides of the array. Light emitted from materials within the capillaries can be carried to a detection system through optical fibers, each of which collects light from a single capillary, with little cross talk between the capillaries.

Abstract: A method and apparatus of determining the size of particles executing Brownian motion is provided. An integrated fiber optic probe, including a length of a gradient index multimode optical fiber fusion spliced to a monomode optical fiber, delivers laser light to a scattering medium such that the light scattered in the backward direction is collected by another integrated fiber optic probe mounted into the same cylindrical housing. The scattered light, after conversion to a series of photoelectron pulses, is processed to determine the mean particle diameter. The temporal coherence of the scattered field from submicroscopic particles illuminated by laser light is a function of both the integration time and the particle diameter. The temporal degree of coherence of the time averaged scattered intensity decreases as the integration time increases. Statistical processing of the scattered photons leads to a new method of particle sizing, which circumvents the need for digital autocorrelation.

Abstract: A method and apparatus for determining the physical characteristics of ocular tissue is provided. A lens-less monomode fiber is caused to generate an expanding beam of monochromatic laser light into ocular tissue such that the light is scattered by the tissue in the backward direction. A second optical fiber, which is multimode at the wavelength of the light passing through the monomode transmission fiber, coherently detects light scattered by the ocular tissue. The scattered light received by the second optical fiber is converted into an electrical signal, which is subsequently analyzed to determine whether changes in the molecular structure of the ocular tissue have occurred.

Abstract: A system for determining the physical properties of materials through the use of dynamic light scattering is disclosed. The system includes a probe, a laser source for directing a laser beam into the probe, and a photodetector for converting scattered light detected by the probe into electrical signals. The probe includes at least one optical fiber connected to the laser source and a second optical fiber connected to the photodetector. Each of the fibers may adjoin a gradient index microlens which is capable of providing a collimated laser beam into a scattering medium. The position of the second optical fiber with respect to the optical axis of the probe determines whether homodyne or self-beating detection is provided. Self-beating detection may be provided without a gradient index microlens. This allows a very small probe to be constructed which is insertable through a hypodermic needle or the like into a droplet extending from such a needle.

Abstract: A laser light scattering and spectroscopic detector is provided which includes a probe comprising an optical fiber coupled to a graded index microlens. The angular aperture and the divergence of the probe are designed specifically to satisfy the scattering volume and coherence requirements for laser light scattering and spectroscopic measurements. The detector includes a housing which defines an elongate cell therein and a selected number of detector ports extending at various angles with respect to the cell. A method is provided for detecting scattered light which includes the steps of positioning the probe inside or outside the scattering medium at a selected angle with respect to the laser beam.

Abstract: A capillary viscometer is provided which includes a fiber-optic probe and a phototransistor which produces an output signal as a liquid meniscus falls through the field of view of a detecting fiber bundle. An analog circuit is employed for receiving the signal and starting or stopping a digital counter in response thereto. The circuit includes first and second differentiators and a zero detection portion for detecting zero value outputs from the second differentiator. The counter is started or stopped upon the generation of a triggering pulse at the time such zero value is detected.