Abstract: The present invention relates to a siglec-6-binding polypeptide that comprises or consists of an antibody or a fragment thereof binding siglec-6 or comprises or consists of a siglec-6-binding chimeric antigen receptor (CAR), a polynucleotide encoding the siglec-6-binding polypeptide, an expression vector comprising the polynucleotide, an immune cell comprising the polypeptide, polynucleotide or expression vector, a method for producing immune cells and a pharmaceutical composition comprising immune cells. The immune cells and the pharmaceutical composition of the present invention may be used in methods for treating a disease, such as cancer, in a patient.

Abstract: Abstract: The invention generally relates to the treatment of cancer with FLT3 targeting agents and kinase inhibitors. In particular, the invention relates to adoptive immunotherapy of Acute Myeloid Leukemia (AML) with chimeric antigen receptor (CAR)-modified T cells specific for FMS-like tyrosine kinase (FLT3) in combination with FLT3 inhibitors.

Abstract: The invention generally relates to the treatment of cancer with FLT3 targeting agents and kinase inhibitors. In particular, the invention relates to adoptive immunotherapy of Acute Myeloid Leukemia (AML) with chimeric antigen receptor (CAR)-modified T cells specific for FMS-like tyrosine kinase (FLT3) in combination with FLT3 inhibitors.