Patents by Inventor Harel Weinstein
Harel Weinstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10859569Abstract: This disclosure is directed to methods of conducting dynamic single-molecule fluorescence studies such as smFRET on a membrane protein which permits observation and quantification of conformational dynamics of a membrane protein. Also disclosed herein are mutant membrane proteins in which one or more mutations have been introduced for affixing a fluorophore, as well as reagents and kits containing such mutant membrane proteins for conducting dynamic single-molecule fluorescence studies. The methods and compositions disclosed herein can be used in screening for compounds that enhance or reduce the activity of a membrane protein, useful for treating diseases associated with the malfunction of the membrane protein or alterations in membrane protein conformation.Type: GrantFiled: November 18, 2016Date of Patent: December 8, 2020Assignees: Cornell University, THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Scott Blanchard, Harel Weinstein, Jonathan Javitch
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Publication number: 20170138933Abstract: This disclosure is directed to methods of conducting dynamic single-molecule fluorescence studies such as smFRET on a membrane protein which permits observation and quantification of conformational dynamics of a membrane protein. Also disclosed herein are mutant membrane proteins in which one or more mutations have been introduced for affixing a fluorophore, as well as reagents and kits containing such mutant membrane proteins for conducting dynamic single-molecule fluorescence studies. The methods and compositions disclosed herein can be used in screening for compounds that enhance or reduce the activity of a membrane protein, useful for treating diseases associated with the malfunction of the membrane protein or alterations in membrane protein conformation.Type: ApplicationFiled: November 18, 2016Publication date: May 18, 2017Applicants: Cornell University, THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Scott BLANCHARD, Harel WEINSTEIN, Jonathan JAVITCH
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Publication number: 20130122525Abstract: This disclosure is directed to methods of conducting dynamic single-molecule fluorescence studies such as sm-FRET on a membrane protein which permits observation and quantification of conformational dynamics of a membrane protein. Also disclosed herein are mutant membrane proteins in which one or more mutations have been introduced for affixing a fluorophore, as well as reagents and kits containing such mutant membrane proteins for conducting dynamic single-molecule fluorescence studies. The methods and compositions disclosed herein can be used in screening for compounds that enhance or reduce the activity of a membrane protein, useful for treating diseases associated with the malfunction of the membrane protein or alterations in membrane protein conformation.Type: ApplicationFiled: May 13, 2011Publication date: May 16, 2013Applicant: CORNELL UNIVERSITYInventors: Scott Blanchard, Harel Weinstein, Jonathan Javitch
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Publication number: 20090217391Abstract: The present invention relates to the discovery, identification and characterization of a receptor protein, referred to herein as T1R3, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses T1R3 nucleotides, host cell expression systems, T1R3 proteins, fusion protein, transgenic animals that express a T1R3 transgene, and recombinant “knock-out” animals that do not express T1R3. The invention further relates to methods for identifying modulators of the T1R3-mediated taste response and the use of such modulators to either inhibit or promote the perception of bitterness or sweetness. The modulators of T1R3 activity may be used as flavor enhancers in food, beverages and pharmaceuticals.Type: ApplicationFiled: July 11, 2008Publication date: August 27, 2009Applicant: Mount Sinai School of Medicine of New York UniversityInventors: Robert MARGOLSKEE, Marianna MAX, Harel WEINSTEIN, Fabien CAMPAGNE, Y. Gopi SHANKER
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Publication number: 20040219632Abstract: The present invention relates to the discovery, identification and characterization of a receptor protein, referred to herein as T1R3, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses T1R3 nucleotides, host cell expression systems, T1R3 proteins, fusion protein, transgenic animals that express a T1R3 transgene, and recombinant “knock-out” animals that do not express T1R3. The invention further relates to methods for identifying modulators of the T1R3-mediated taste response and the use of such modulators to either inhibit or promote the perception of bitterness or sweetness. The modulators of T1R3 activity may be used as flavor enhancers in foods, beverages and pharmaceuticals.Type: ApplicationFiled: April 29, 2004Publication date: November 4, 2004Inventors: Robert Margolskee, Marianna Max, Harel Weinstein, Fabien Campagne, Gopi Y. Shanker
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Publication number: 20030157644Abstract: The present invention relates generally to the field of peptides and other small molecules (i.e. peptide mimetics) as pharmaceutical and/or therapeutic agents, and to methods for identification and design of peptides and peptide mimetics having desired functional activities. Specifically, peptides and other small molecules derived from regions of interacting intracellular signaling proteins are provided. More specifically, peptides and other small molecules derived from regions of the G&bgr; subunit of heterotrimeric GTP binding proteins are provided. Such molecules include specific agonists and antagonists of G&bgr; downstream effectors, including adenylyl cyclase and phospholipase C. Such molecules are targeted to predicted regions of interaction between intracellular signaling proteins and tested for activity in functional assays using methods of the invention.Type: ApplicationFiled: December 16, 2002Publication date: August 21, 2003Applicant: Mount Sinai School of Medicine of the City University of New YorkInventors: Srinivas Ravi V. Iyengar, Gezhi Weng, Yibang Chen, Harel Weinstein, Elizabeth Buck
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Patent number: 6555522Abstract: The present invention relates generally to the field of peptides and other small molecules (i.e. peptide mimetics) as pharmaceutical and/or therapeutic agents, and to methods for identification and design of peptides and peptide mimetics having desired functional activities. Specifically, peptides and other small molecules derived from regions of interacting intracellular signaling proteins are provided. More specifically, peptides and other small molecules derived from regions of the G&bgr; subunit of heterotrimeric GTP binding proteins are provided. Such molecules include specific agonists and antagonists of G&bgr; downstream effectors, including adenylyl cyclase and phospholipase C. Such molecules are targeted to predicted regions of interaction between intracellular signaling proteins and tested for activity in functional assays using methods of the invention.Type: GrantFiled: February 5, 1999Date of Patent: April 29, 2003Assignee: Mount Sinai School of Medicine of the City of New YorkInventors: Srinivas Ravi V. Iyengar, Gezhi Weng, Yibang Chen, Harel Weinstein, Elizabeth Buck