Patents by Inventor Haridas Pudavar

Haridas Pudavar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7413341
    Abstract: A method of local temperature measurement in a sample is provided. The method comprises the stimulation, at a location in the sample, of anti-Stokes and Stokes emission from fluorophores which are present at the location in the sample, measuring the intensities of the stimulated radiation and calculating the temperature at the location from the measured intensities. The method can be used to obtain a thermal image of the sample.
    Type: Grant
    Filed: August 16, 2005
    Date of Patent: August 19, 2008
    Assignee: The Research Foundation of State University of New York
    Inventors: Aliaksandr Kachynski, Andrey Kuzmin, Haridas Pudavar, Paras N. Prasad
  • Patent number: 7364754
    Abstract: The present invention provides methods and compositions for photodynamic therapy. The composition comprises ceramic nanoparticles in which a photosensitive drug/dye is entrapped. The ceramic nanoparticles are made by formation of a micellar composition of the dye. The ceramic material is added to the micellar composition and the ceramic nanoparticles are precipitated by alkaline hydrolysis. The precipitated nanoparticles in which the photosensitive dye/drug is entrapped can be isolated by dialysis. The resulting drug doped nanoparticles are spherical, highly monodispersed, and stable in aqueous system. Irradiation with light of suitable wavelength of the photosensitizing drug entrapped inside nanoparticles resulted in generation of singlet oxygen, which was able to diffuse out through the pores of the ceramic matrix. The drug loaded ceramic nanoparticles of the present invention can be used as drug carriers for photodynamic therapy.
    Type: Grant
    Filed: January 26, 2004
    Date of Patent: April 29, 2008
    Assignee: Research Foundation of the State University of New York
    Inventors: Paras Prasad, Indrajit Roy, Earl J. Bergey, Tymish Y. Ohulchansky, Haridas Pudavar
  • Publication number: 20070134340
    Abstract: This invention provides nanocrystals or polymer doped nanocrystals of hydrophobic drug molecules as stably dispersed in an aqueous system which are prepared without stabilizers like surfactants and the like. In one embodiment, the drug is a tetra-pyrrole compound. An example is the hydrophobic photosensitizing anticancer drug 2-devinyl-2-(1-hexyloxyethyl)pyropheophorbide (HPPH). Pharmaceutical compositions comprising nanocrystals or polymer doped nanocrystals of hydrophobic drugs can be used for therapeutic purposes. For example pyropheophorbides such as HPPH can be used for photodynamic therapy. Drug efficacy of these nanocrystals were found to be comparable with that of same drug formulated in conventional delivery vehicles under in vitro and in vivo conditions.
    Type: Application
    Filed: June 20, 2006
    Publication date: June 14, 2007
    Inventors: Paras Prasad, Haridas Pudavar, Koichi Baba, Indrajit Roy, Tymish Ohulchanskyy, Ravindra Pandey, Allan Oseroff
  • Publication number: 20070086949
    Abstract: This invention provides nanocrystals or polymer doped nanocrystals of hydrophobic organic fluorescent dyes as stable dispersions in an aqueous system. The dispersions can be prepared without stabilizers such as surfactants and the like. The aqueous dispersions of the nanocrystals or the polymer doped nanocrystals can be used for bioimaging.
    Type: Application
    Filed: June 20, 2006
    Publication date: April 19, 2007
    Inventors: Paras Prasad, Koichi Baba, Haridas Pudavar, Indrajit Roy, Tymish Ohulchanskyy, Hachiro Nakanishi, Akito Masuhara, Hitoshi Kasai
  • Publication number: 20040180096
    Abstract: The present invention provides methods and compositions for photodynamic therapy. The composition comprises ceramic nanoparticles in which a photosensitive drug/dye is entrapped. The ceramic nanoparticles are made by formation of a micellar composition of the dye. The ceramic material is added to the micellar composition and the ceramic nanoparticles are precipitated by alkaline hydrolysis. The precipitated nanoparticles in which the photosensitive dye/drug is entrapped can be isolated by dialysis. The resulting drug doped nanoparticles are spherical, highly monodispersed, and stable in aqueous system. Irradiation with light of suitable wavelength of the photosensitizing drug entrapped inside nanoparticles resulted in generation of singlet oxygen, which was able to diffuse out through the pores of the ceramic matrix. The drug loaded ceramic nanoparticles of the present invention can be used as drug carriers for photodynamic therapy.
    Type: Application
    Filed: January 26, 2004
    Publication date: September 16, 2004
    Inventors: Paras Prasad, Indrajit Roy, Earl J. Bergey, Tymish Y. Ohulchansky, Haridas Pudavar