Patents by Inventor Harihara M. Mehendale

Harihara M. Mehendale has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Intramural Research Program of the National Institutes of Health, National Institute of Environmental Health Sciences (NIEHS)
    Publication number: 20130253060
    Abstract: Use of sPLA2 inhibitors (for example, BPPA (5-(4-Benzyloxyphenyl)-4S-(7-phenylheptanoylamino) pentanoic acid)) within about 9 hours after poisoning with a liver toxin, for example, acetaminophen (APAP), was shown to increase survivorship. The inhibition of sPLA2 lead to markedly decreased progression of liver injury as reflected in lower alanine aminotransferase (ALT—a biomarker for liver injury) levels, and to significantly higher survival rates. Similar treatment in human patients suffering from hepatotoxicity will be effective in increasing survival, and treatment with other sPLA2 inhibitors will also be effective in decreasing liver damage and mortality.
    Type: Application
    Filed: September 13, 2012
    Publication date: September 26, 2013
    Inventor: Harihara M. Mehendale