Patents by Inventor Harini KALUARACHCHI

Harini KALUARACHCHI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CYSTINE KNOT SCAFFOLD PLATFORM
    Publication number: 20230174596
    Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.
    Type: Application
    Filed: June 17, 2022
    Publication date: June 8, 2023
    Inventors: Rami HANNOUSH, Harini KALUARACHCHI, Aaron NILE, Cameron NOLAND, Yingnan ZHANG, Lijuan ZHOU, Xinxin GAO
  • Cystine knot scaffold platform
    Patent number: 11407794
    Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.
    Type: Grant
    Filed: August 19, 2019
    Date of Patent: August 9, 2022
    Assignee: Genetech, Inc.
    Inventors: Rami Hannoush, Harini Kaluarachchi, Aaron Nile, Cameron Noland, Yingnan Zhang, Lijuan Zhou, Xinxin Gao
  • Cystine knot scaffold platform
    Patent number: 11155586
    Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.
    Type: Grant
    Filed: September 18, 2019
    Date of Patent: October 26, 2021
    Assignee: Genentech, Inc.
    Inventors: Rami Hannoush, Harini Kaluarachchi, Aaron Nile, Cameron Noland, Yingnan Zhang, Lijuan Zhou, Xinxin Gao
  • Cystine knot scaffold platform
    Patent number: 11078243
    Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.
    Type: Grant
    Filed: September 18, 2019
    Date of Patent: August 3, 2021
    Assignee: Genentech, Inc.
    Inventors: Rami Hannoush, Harini Kaluarachchi, Aaron Nile, Cameron Noland, Yingnan Zhang, Lijuan Zhou, Xinxin Gao
  • CYSTINE KNOT SCAFFOLD PLATFORM
    Publication number: 20200325187
    Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, Including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.
    Type: Application
    Filed: June 29, 2020
    Publication date: October 15, 2020
    Applicant: Genentech, Inc.
    Inventors: Rami HANNOUSH, Harini KALUARACHCHI, Aaron NILE, Cameron NOLAND, Yingnan ZHANG, Lijuan ZHOU, Xinxin GAO
  • CYSTINE KNOT SCAFFOLD PLATFORM
    Publication number: 20200231636
    Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.
    Type: Application
    Filed: September 18, 2019
    Publication date: July 23, 2020
    Inventors: Rami HANNOUSH, Harini KALUARACHCHI, Aaron NILE, Cameron NOLAND, Yingnan ZHANG, Lijuan ZHOU, Xinxin GAO
  • Cystine knot scaffold platform
    Patent number: 10696721
    Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: June 30, 2020
    Assignee: Genentech, Inc.
    Inventors: Rami Hannoush, Harini Kaluarachchi, Aaron Nile, Cameron Noland, Yingnan Zhang, Lijuan Zhou, Xinxin Gao
  • CYSTINE KNOT SCAFFOLD PLATFORM
    Publication number: 20200140498
    Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.
    Type: Application
    Filed: September 18, 2019
    Publication date: May 7, 2020
    Inventors: Rami HANNOUSH, Harini KALUARACHCHI, Aaron NILE, Cameron NOLAND, Yingnan ZHANG, Lijuan ZHOU, Xinxin GAO
  • CYSTINE KNOT SCAFFOLD PLATFORM
    Publication number: 20200115424
    Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.
    Type: Application
    Filed: August 19, 2019
    Publication date: April 16, 2020
    Applicant: Genentech, Inc.
    Inventors: Rami HANNOUSH, Harini KALUARACHCHI, Aaron NILE, Cameron NOLAND, Yingnan ZHANG, Lijuan ZHOU, Xinxin GAO
  • Cystine knot scaffold platform
    Patent number: 10428125
    Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.
    Type: Grant
    Filed: September 15, 2016
    Date of Patent: October 1, 2019
    Assignee: Genentech, Inc.
    Inventors: Rami Hannoush, Harini Kaluarachchi, Aaron Nile, Cameron Noland, Yingnan Zhang, Lijuan Zhou, Xinxin Gao
  • CYSTINE KNOT SCAFFOLD PLATFORM
    Publication number: 20180291069
    Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.
    Type: Application
    Filed: April 3, 2018
    Publication date: October 11, 2018
    Inventors: Rami HANNOUSH, Harini KALUARACHCHI, Aaron NILE, Cameron NOLAND, Yingnan ZHANG, Lijuan ZHOU, Xinxin GAO
  • CYSTINE KNOT SCAFFOLD PLATFORM
    Publication number: 20170129927
    Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.
    Type: Application
    Filed: September 15, 2016
    Publication date: May 11, 2017
    Inventors: Rami HANNOUSH, Harini KALUARACHCHI, Aaron NILE, Cameron NOLAND, Yingnan ZHANG, Lijuan ZHOU, Xinxin GAO