Patents by Inventor Haris J. Sih
Haris J. Sih has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9173586Abstract: A system and method for assessing a degree of coupling between an electrode and tissue in a body is provided. Values for first and second components of a complex impedance (e.g., resistance and reactance or impedance magnitude and phase angle) between the electrode and the tissue are obtained. These values are used together with a standardization value indicative of a deviation from a reference standard by a parameter associated with at least one of the body, the electrode and another component of the system to calculate a coupling index that is indicative of a degree of coupling between the electrode and the tissue. The coupling index may be displayed to a clinician in a variety of ways to indicate the degree of coupling to the clinician. The system and method find particular application in ablation of tissue by permitting a clinician to create lesions in the tissue more effectively and safely.Type: GrantFiled: February 26, 2013Date of Patent: November 3, 2015Assignee: St. Jude Medical, Atrial Fibrillation Division, Inc.Inventors: Don Curtis Deno, Stephan P. Miller, Lewis C. Hill, Yuriy Malinin, Haris J. Sih
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Patent number: 9031792Abstract: A system and device are provided which include a gene regulatory system controlling expression of one or more expression cassettes present in or released by the device, by emitting one or more stimulations. An expression cassette includes a regulatable transcription control element that is responsive to the emitted stimulations linked to an open reading frame of interest. The system optionally includes a sensor to sense a parameter indicative of a need, a telemetry module to receive an external command, or a programmable device, for regulating gene expression of the open reading frame.Type: GrantFiled: March 27, 2006Date of Patent: May 12, 2015Assignee: Cardiac Pacemakers, Inc.Inventors: Darrell O. Wagner, Haris J. Sih, Jihong Qu, Jeffrey Ross, Steven D. Girouard, Ronald W. Heil, Jr.
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Patent number: 8874204Abstract: Implantable devices containing extracellular matrix and methods of using the devices are provided.Type: GrantFiled: December 20, 2004Date of Patent: October 28, 2014Assignee: Cardiac Pacemakers, Inc.Inventors: Haris J. Sih, Joseph M. Pastore
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Patent number: 8874207Abstract: A stimulation system delivers stimulation to protect an ischemic region of a body from tissue damage caused by ischemia. The stimulation is delivered to one or more stimulation sites remote from the ischemic region to elicit a physiological effect that protects the ischemic region from the tissue damage caused by ischemia. In one embodiment, the stimulation system delivers cardioprotective stimulation to one or more stimulation sites remote from the heart to protect the heart from injuries associated with cardiac ischemic events. In another embodiment, the stimulation system delivers remote conditioning stimulation to one or more stimulation sites in or on the heart to protect a non-cardiac region from injuries associated with non-cardiac ischemic events.Type: GrantFiled: December 8, 2010Date of Patent: October 28, 2014Assignee: Cardiac Pacemakers, Inc.Inventors: Haris J. Sih, Tamara Colette Baynham, Darrell O. Wagner
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Patent number: 8831726Abstract: Methods and devices for classifying a cardiac response to pacing involve establishing a plurality of classification windows relative to and following a pacing pulse. One or more characteristics of a cardiac signal sensed following the pacing pulse are detected within one or more particular classification windows. The characteristics may be compared to one or more references. Classification of the cardiac response may be performed based on the comparison of the one or more characteristics to the one or more references and the particular classification windows in which the one or more characteristics are detected.Type: GrantFiled: January 15, 2008Date of Patent: September 9, 2014Assignee: Cardiac Pacemakers, Inc.Inventors: Jaeho Kim, Joseph Bocek, Scott A. Meyer, Paul A. Haefner, Haris J. Sih
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Publication number: 20140107430Abstract: A system and method for assessing a degree of coupling between an electrode and tissue in a body is provided. Values for first and second components of a complex impedance (e.g., resistance and reactance or impedance magnitude and phase angle) between the electrode and the tissue are obtained. These values are used together with a standardization value indicative of a deviation from a reference standard by a parameter associated with at least one of the body, the electrode and another component of the system to calculate a coupling index that is indicative of a degree of coupling between the electrode and the tissue. The coupling index may be displayed to a clinician in a variety of ways to indicate the degree of coupling to the clinician. The system and method find particular application in ablation of tissue by permitting a clinician to create lesions in the tissue more effectively and safely.Type: ApplicationFiled: February 26, 2013Publication date: April 17, 2014Applicant: St. Jude Medical, Atrial Fibrillation Division, Inc.Inventors: Don Curtis Deno, Stephan P. Miller, Lewis C. Hill, Yuriy Malinin, Haris J. Sih
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Patent number: 8585641Abstract: Devices to treat nerves which innervate blood vessels are provided.Type: GrantFiled: November 2, 2011Date of Patent: November 19, 2013Assignee: Cardiac Pacemakers, Inc.Inventor: Haris J. Sih
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Patent number: 8568286Abstract: A system for controlling the location of a therapeutic agent administered to a mammal is provided. The system employs a device that is capable of generating a magnetic field and a therapeutic agent labeled with a magnetically responsive moiety. Methods which employ the device and the therapeutic agent are also provided.Type: GrantFiled: June 14, 2006Date of Patent: October 29, 2013Assignee: Cardiac Pacemakers, Inc.Inventors: Haris J. Sih, Craig Stolen, Jihong Ou, Darrell O. Wagner
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Patent number: 8521284Abstract: Methods and devices for classifying a cardiac pacing response involve using a first electrode combination for pacing and a second electrode combination for sensing a cardiac signal following pacing. The cardiac response to pacing may be classified using the sensed cardiac signal. One process involves using the sensed cardiac signal to detect the cardiac response as a fusion/pseudofusion beat. Another process involves using the sensed cardiac signal to classify the cardiac response to pacing as one of at least three cardiac response types.Type: GrantFiled: December 12, 2003Date of Patent: August 27, 2013Assignee: Cardiac Pacemakers, Inc.Inventors: Jaeho Kim, Joseph Bocek, Scott A. Meyer, Paul A. Haefner, Haris J. Sih
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Patent number: 8311620Abstract: The invention provides a cardiac rhythm management system which includes a tachyarrhythmia detection and classification circuit programmed to detect and classify a tachyarrhythmia, a biologic therapy delivery device configured to deliver or regulate an expression cassette suitable for terminating or preventing atrial fibrillation (AF), and a control circuit coupled to the tachyarrhythmia detection and classification circuit and the biologic therapy delivery device. Also provided is an implantable medical device for use in a body having a cardiovascular system, which includes an implantable device body including at least a cardiovascular portion configured to be in the cardiovascular system, and an expression cassette incorporated into the cardiovascular portion of the implantable device body, the expression cassette selected to express a gene product that terminates or prevents AF. Further provided are methods which employ particular expression cassettes to prevent, inhibit or treat AF.Type: GrantFiled: August 22, 2007Date of Patent: November 13, 2012Assignee: Cardiac Pacemakers, Inc.Inventors: Jihong Qu, Haris J. Sih, Mark Schwartz, Prashant Sinha
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Publication number: 20120109278Abstract: Devices and methods to treat atrial fibrillation via inhibition of nerves which innervate the pulmonary vein are provided.Type: ApplicationFiled: November 2, 2011Publication date: May 3, 2012Inventor: Haris J. Sih
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Patent number: 8052668Abstract: Devices and methods to treat atrial fibrillation via inhibition of nerves which innervate the pulmonary vein are provided.Type: GrantFiled: May 12, 2006Date of Patent: November 8, 2011Assignee: Cardiac Pacemakers, Inc.Inventor: Haris J. Sih
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Patent number: 7979124Abstract: A method and device provide for determining capture in multiple chambers of a patient's heart using an electrode inserted into a coronary vein of the patient's heart. The coronary vein electrode is positioned adjacent to multiple heart chambers and is responsive to cardiac signals originating in the multiple chambers. The coronary vein electrode may be coupled to a single sense amplifier to detect the cardiac signals. Pace pulses may be applied to multiple heart chambers simultaneously or according to a phased timing sequence. Cardiac signals responsive to the pace pulses sensed using the coronary vein electrode may be used to verify capture in the multiple chambers of the heart.Type: GrantFiled: November 16, 2006Date of Patent: July 12, 2011Assignee: Cardiac Pacemakers, Inc.Inventors: Scott A. Meyer, Haris J. Sih, Paul A. Haefner
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Publication number: 20110137385Abstract: An implantable medical device includes a light emitting circuit incorporated into an intravascular stent. The light emitting circuit emits a light to an ischemic region. The light has characteristics suitable for reliving the angina symptoms associated with ischemia.Type: ApplicationFiled: February 10, 2011Publication date: June 9, 2011Inventors: Tamara Colette Baynham, Darrell O. Wagner, Haris J. Sih
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Publication number: 20110077701Abstract: A stimulation system delivers stimulation to protect an ischemic region of a body from tissue damage caused by ischemia. The stimulation is delivered to one or more stimulation sites remote from the ischemic region to elicit a physiological effect that protects the ischemic region from the tissue damage caused by ischemia. In one embodiment, the stimulation system delivers cardioprotective stimulation to one or more stimulation sites remote from the heart to protect the heart from injuries associated with cardiac ischemic events. In another embodiment, the stimulation system delivers remote conditioning stimulation to one or more stimulation sites in or on the heart to protect a non-cardiac region from injuries associated with non-cardiac ischemic events.Type: ApplicationFiled: December 8, 2010Publication date: March 31, 2011Inventors: Haris J. Sih, Tamara Colette Baynham, Darrell O. Wagner
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Patent number: 7885710Abstract: A stimulation system delivers stimulation to protect an ischemic region of a body from tissue damage caused by ischemia. The stimulation is delivered to one or more stimulation sites remote from the ischemic region to elicit a physiological effect that protects the ischemic region from the tissue damage caused by ischemia. In one embodiment, the stimulation system delivers cardioprotective stimulation to one or more stimulation sites remote from the heart to protect the heart from injuries associated with cardiac ischemic events. In another embodiment, the stimulation system delivers remote conditioning stimulation to one or more stimulation sites in or on the heart to protect a non-cardiac region from injuries associated with non-cardiac ischemic events.Type: GrantFiled: December 23, 2005Date of Patent: February 8, 2011Assignee: Cardiac Pacemakers, Inc.Inventors: Haris J. Sih, Tamara Colette Baynham, Darrell O. Wagner
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Patent number: 7702388Abstract: The present disclosure provides methods and systems for tachyarrhythmia therapy involving pacing the heart to prior to the application of a cardioversion/defibrillation shock. One or more pace pulses are delivered to the arrhythmic chamber or chambers. The pace pulses may be delivered to the heart at an adaptable rate selected to organize the electrical activity of the heart. If the pace pulses produce capture, cardioversion/defibrillation stimulation is delivered.Type: GrantFiled: February 28, 2003Date of Patent: April 20, 2010Assignee: Cardiac Pacemakers, Inc.Inventors: Haris J. Sih, Scott A. Meyer, Paul A. Haefner
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Patent number: 7630761Abstract: A biologic agent delivery system provides for delivery of a biologic agent to a stimulation site to which electrical stimulation pulses are to be delivered from an electrical stimulation device. Examples of the electrical stimulation device include cardiac pacemakers and neural stimulators. The biologic agent modifies tissue property to lower the stimulation threshold of the stimulation site. The genetic modification of the tissue property improves efficacy and/or energy efficiency of an electrical stimulation therapy.Type: GrantFiled: November 4, 2005Date of Patent: December 8, 2009Assignee: Cardiac Pacemakers, Inc.Inventors: Rodney W. Salo, Joseph M. Pastore, Haris J. Sih, Jihong Qu
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Patent number: 7574258Abstract: The present invention provides methods and systems for tachyarrhythmia therapy involving pacing the heart to prior to the application of a cardioversion/defibrillation shock. One or more pace pulses are delivered to the arrhythmic chamber or chambers. The pace pulses may be delivered to the heart at an adaptable rate selected to organize the electrical activity of the heart. If the pace pulses produce capture, cardioversion/defibrillation stimulation is delivered.Type: GrantFiled: December 14, 2005Date of Patent: August 11, 2009Assignee: Cardiac Pacemakers, Inc.Inventors: Haris J. Sih, Scott A. Meyer, Paul A. Haefner
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Publication number: 20090054943Abstract: The invention provides a cardiac rhythm management system which includes a tachyarrhythmia detection and classification circuit programmed to detect and classify a tachyarrhythmia, a biologic therapy delivery device configured to deliver or regulate an expression cassette suitable for terminating or preventing atrial fibrillation (AF), and a control circuit coupled to the tachyarrhythmia detection and classification circuit and the biologic therapy delivery device. Also provided is an implantable medical device for use in a body having a cardiovascular system, which includes an implantable device body including at least a cardiovascular portion configured to be in the cardiovascular system, and an expression cassette incorporated into the cardiovascular portion of the implantable device body, the expression cassette selected to express a gene product that terminates or prevents AF. Further provided are methods which employ particular expression cassettes to prevent, inhibit or treat AF.Type: ApplicationFiled: August 22, 2007Publication date: February 26, 2009Applicant: Cardiac Pacemakers, Inc.Inventors: Jihong Qu, Haris J. Sih, Mark Schwartz, Prashant Sinha