Abstract: A nuclear magnetic resonance (NMR) power supply system and method are disclosed. The architecture adopts a two-stage topology to reduce the required capacitance by over ten times, leading to a four-fold improvement in power density. The first stage is an isolated converter that only supplies average power, therefore input filter and transformer sizes can be reduced. The second stage is a fast response DC-DC converter followed by a RF transmitter to produce a pulsed RF signal, so that the mid-point voltage after the first stage can be allowed to droop considerably, leading to much smaller sized capacitors. These and other embodiments enforce the isolated converter to only transfer average power, which reduces the power rating and the volume of the system's transformer.