Patents by Inventor Harlan H. Chapman

Harlan H. Chapman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prodrugs of phosphonate nucoleotide analogues
    Patent number: 7803788
    Abstract: A novel method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided.
    Type: Grant
    Filed: April 28, 2008
    Date of Patent: September 28, 2010
    Assignee: Gilead Sciences, Inc.
    Inventors: Mark W. Becker, Harlan H. Chapman, Tomas Cihlar, Eugene J. Eisenberg, Gong-Xin He, Michael R. Kernan, William A. Lee, Ernest J. Prisbe, John C. Rohloff, Mark L. Sparacino
  • PRODRUGS OF PHOSPHONATE NUCLEOTIDE ANALOGUES
    Publication number: 20080227754
    Abstract: A novel method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided.
    Type: Application
    Filed: April 28, 2008
    Publication date: September 18, 2008
    Inventors: Mark W. Becker, Harlan H. Chapman, Tomas Cihlar, Eugene J. Eisenberg, Gong-Xin He, Michael R. Kernan, William A. Lee, Ernest J. Prisbe, John C. Rohloff, Mark L. Sparacino
  • Prodrugs of phosphonate nucleotide analogues
    Patent number: 7390791
    Abstract: A novel method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided.
    Type: Grant
    Filed: March 11, 2004
    Date of Patent: June 24, 2008
    Assignee: Gilead Sciences, Inc.
    Inventors: Mark W. Becker, Harlan H. Chapman, Tomas Cihlar, Eugene J. Eisenberg, Gong-Xin He, Michael R. Kernan, William A. Lee, Ernest J. Prisbe, John C. Rohloff, Mark L. Sparacino
  • Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same
    Publication number: 20040018150
    Abstract: A novel method is provided for screening prodrugs of methoxyphosphonate nucleotide analogues to identify prodrugs selectively targeting desired tissues with antiviral or antitumor activity. This method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided. Also provided is an improved method for the use of magnesium alkoxide for the preparation of starting materials and compounds for use herein.
    Type: Application
    Filed: January 14, 2003
    Publication date: January 29, 2004
    Inventors: Mark W. Becker, Harlan H. Chapman, Tomas Cihlar, Eugene J. Eisenberg, Gong-Xi He, Michael R. Kernan, William A. Lee, Ernest J. Prisbe, John C. Rohloff, Mark L. Sparacino
  • Prodrugs of phosphonate nucleotide analogues
    Publication number: 20030219727
    Abstract: A novel method is provided for screening prodrugs of methoxyphosphonate nucleotide analogues to identify prodrugs selectively targeting desired tissues with antiviral or antitumor activity.
    Type: Application
    Filed: June 16, 2003
    Publication date: November 27, 2003
    Inventors: Mark W. Becker, Harlan H. Chapman, Tomas Cihlar, Eugene J. Eisenberg, Gong-Xin He, Michael R. Kernan, William A. Lee, Ernest J. Prisbe, John C. Rohloff, Mark L. Sparacino
  • Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same
    Publication number: 20020119443
    Abstract: A novel method is provided for screening prodrugs of methoxyphosphonate nucleotide analogues to identify prodrugs selectively targeting desired tissues with antiviral or antitumor activity.
    Type: Application
    Filed: July 20, 2001
    Publication date: August 29, 2002
    Applicant: GILEAD SCIENCES, INC.
    Inventors: Mark W. Becker, Harlan H. Chapman, Tomas Cihlar, Eugene J. Eisenberg, Gong-Xin He, Michael R. Kernan, William A. Lee, Ernest J. Prisbe, John C. Rohloff, Mark L. Sparacino
  • Alkoxy methyl ether and alkoxy methyl ester derivatives
    Patent number: 5225590
    Abstract: Intermediates and methods for producing intermediates for use in preparing 9-(1,3-dihydroxy-2-propoxymethyl)-guanine and esters and ethers thereof.
    Type: Grant
    Filed: April 26, 1988
    Date of Patent: July 6, 1993
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: David J. Morgans, Jr., Harlan H. Chapman