Abstract: The present disclosure relates to systems, non-transitory computer-readable media, and methods for intelligently predicting a persona class of a client device and/or target user utilizing an overlap-agnostic machine learning model and distributing persona-based digital content to the client device. In particular, in one or more embodiments, the persona classification system can learn overlap-agnostic machine learning model parameters to apply to user traits in real-time or in offline batches. For example, the persona classification system can train and utilize an overlap-agnostic machine learning model that includes an overlap-agnostic embedding model, a trained user-embedding generation model, and a trained persona prediction model. By applying the learned overlap-agnostic machine learning model parameters to the target user traits, the persona classification system can predict a persona class for sending digital content based on the predicted persona class.