Patents by Inventor Harm Vrieling

Harm Vrieling has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polynucleotides comprising a reporter sequence operatively linked to a regulatory element
    Patent number: 9695481
    Abstract: The invention provides a polynucleotide comprising a reporter sequence operatively linked to a regulatory element of a gene selected from Bscl2, Srxnl, Cbr3, Ephxl, Nope, Cdknla, Perp, Pltp, Cgrefl, Ltb4r1, Btg2, Gpx2, Ltb4r2, Ddit4l, Fosl1, and Egr1, which regulatory element stimulates expression of the reporter sequence in response to a genotoxic agent or to an oxidative stress-inducing agent. The invention also provides a method of detecting a genotoxic or oxidative stress-inducing agent comprising subjecting a cell containing the polynucleotide of the invention to a test agent; and assessing the expression of the reporter sequence.
    Type: Grant
    Filed: September 15, 2011
    Date of Patent: July 4, 2017
    Assignees: UNIVERSITEIT LEIDEN, ACADEMISCH ZIEKENHUIS LEIDEN
    Inventors: Bob Van de Water, Harm Vrieling
  • Screening Method
    Publication number: 20130302815
    Abstract: The invention provides a polynucleotide comprising a reporter sequence operatively linked to a regulatory element of a gene selected from Bscl2, Srxnl, Cbr3, Ephxl, Nope, Cdknla, Perp, Pltp, Cgrefl, Ltb4r1, Btg2, Gpx2, Ltb4r2, Ddit4l, Fosl1, and Egr1, which regulatory element stimulates expression of the reporter sequence in response to a genotoxic agent or to an oxidative stress-inducing agent. The invention also provides a method of detecting a genotoxic or oxidative stress-inducing agent comprising subjecting a cell containing the polynucleotide of the invention to a test agent; and assessing the expression of the reporter sequence.
    Type: Application
    Filed: September 15, 2011
    Publication date: November 14, 2013
    Applicants: ACADEMISCH ZIEKENHUIS LEIDEN also acting under the name LEIDEN UNIVERSITY MEDICAL CENTER, UNIVERSITEIT LEIDEN
    Inventors: Bob Van de Water, Harm Vrieling