Patents by Inventor Harma Feitsma

Harma Feitsma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Devices and methods for microarray selection
    Patent number: 9493822
    Abstract: The present invention relates to a device for the specific selection of target molecules, wherein immobilized capture molecules can be organized in a microarray in the form of spots or lines. In a further aspect the present invention relates to a method of specifically selecting target molecules in a reaction zone, as well as the use of such a device for specifically selecting target molecules, e.g. for target enrichment, or microarray based genome selection (MGS).
    Type: Grant
    Filed: August 26, 2010
    Date of Patent: November 15, 2016
    Assignee: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: Pieter Jan Van Der Zaag, Harma Feitsma, Jacob Marinus Jan Den Toonder, Reinhold Wimberger-Friedl
  • Method for amplifying nucleic acids
    Patent number: 9005896
    Abstract: The present invention describes methods for amplifying a target nucleic acid wherein target nucleic acids hybridize to capture probe nucleic acids which are immobilized to a support via their 5? end. The hybridization product is further extended with a polymerase to form a double stranded nucleic acid. To this double stranded nucleic acid, a hairpin nucleic acid is ligated. This ligation product is further amplified and sequenced.
    Type: Grant
    Filed: August 31, 2011
    Date of Patent: April 14, 2015
    Assignee: Koninklijke Philips N.V.
    Inventors: Harma Feitsma, Marlieke Overdijk, Anja Van De Stople, Pieter Jan Van Der Zaag
  • METHOD FOR AMPLIFYING NUCLEIC ACIDS
    Publication number: 20130210008
    Abstract: The present invention describes methods for amplifying a target nucleic acid wherein target nucleic acids hybridise to capture probe nucleic acids which are immobilized to a support via their 5? end. The hybridization product is further extended with a polymerase to form a double stranded nucleic acid. To this double stranded nucleic acid, a hairpin nucleic acid is ligated. This ligation product is further amplified and sequenced.
    Type: Application
    Filed: August 31, 2011
    Publication date: August 15, 2013
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: Harma Feitsma, Marlieke Overdijk, Anja Van De Stople, Pieter Jan Van Der Zaag
  • DEVICES AND METHODS FOR MICROARRAY SELECTION
    Publication number: 20120165219
    Abstract: The present invention relates to a device for the specific selection of target molecules, comprising: (a) at least one reaction zone comprising a microarray, wherein the microarray comprises a substrate, on which one or more species of capture molecules are immobilized, comprising one or more temperature control and/or regulating units for controlling and/or regulating the temperature within the zone; (b) at least one non-reaction zone comprising one or more temperature control and/or regulating units for controlling and/or regulating the temperature within the zone, which is in fluid connection with the reaction zone; and (c) at least one transportation means capable of generating and/or regulating a fluid flow between said reaction zone (a) and said non-reaction zone comprising one or more temperature control and/or regulating units (b).
    Type: Application
    Filed: August 26, 2010
    Publication date: June 28, 2012
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: Pieter Jan Van Der Zaag, Harma Feitsma, Jacob Marinus Jan Den Toonder, Reinhold Wimberger-Friedl