Patents by Inventor Harman S. Lowrie

Harman S. Lowrie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Metabolites of pentanedioic acid derivatives
    Patent number: 5233063
    Abstract: The present invention relates to pentanedioic acid derivatives. The present invention further relates to pharmaceutical compositions containing such compounds and the use of such compounds and compositions as hypolipidemic drugs.
    Type: Grant
    Filed: January 16, 1991
    Date of Patent: August 3, 1993
    Assignee: G. D. Searle & Co.
    Inventors: John S. Baran, Harman S. Lowrie
  • Metabolites of pentanedioic acid derivatives
    Patent number: 5055613
    Abstract: The present invention relates to pentanedioic acid derivatives. The present invention further relates to pharmaceutical compositions containing such compounds and to the use of such compounds and compositions as hypolipidemic drugs.
    Type: Grant
    Filed: February 18, 1988
    Date of Patent: October 8, 1991
    Assignee: G. D. Searle & Co.
    Inventors: John S. Baran, Harman S. Lowrie
  • Substituted glutaric acid lactones in the treatment of hyperlipidemia
    Patent number: 5041694
    Abstract: Compounds of formula I ##STR1## are described which are useful to inhibit the formation of serum cholesterol by virtue of their ability to inhibit .beta.-hydroxy-.beta.-methylglutaryl-CoA(HMG CoA), the rate-controlling substance in the synthesis of serum cholesterol.
    Type: Grant
    Filed: October 13, 1989
    Date of Patent: August 20, 1991
    Assignee: G. D. Searle & Co.
    Inventors: John S. Baran, Thomas J. Lindberg, Harman S. Lowrie
  • S-diastereomer of an n.sup.6 -((2-hydroxypropyl)aryl)adenosine and its medicinal uses
    Patent number: 5032584
    Abstract: A novel S diastereomer of an N.sup.6 -[(2-hydroxypropyl)aryl] adenosine, which diastereomer exhibits fewer CNS side effects than the racemate, but with no decrease in cardiovascular activity. The invention further provides for compositions incorporating the diastereomer, and methods of its use, as well as pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: October 26, 1988
    Date of Patent: July 16, 1991
    Assignee: G. D. Searle & Co.
    Inventors: Harman S. Lowrie, Gerald M. Walsh
  • R-diastereomer of an N.sup.6 -[(2-hydroxypropyl)aryl]adenosine and its medicinal uses
    Patent number: 5030624
    Abstract: A novel R diastereomer of an N.sup.6 -[(2-hydroxypropyl)aryl]adenosine, which diastereomer exhibits fewer CNS side effects than the racemate, but with no decrease in cardiovascular activity. The invention further provides for compositions incorporating the diastereomer, and methods of its use as well as pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: October 26, 1988
    Date of Patent: July 9, 1991
    Assignee: G. D. Searle & Co.
    Inventors: Harman S. Lowrie, Gerald M. Walsh
  • Substituted glutaric acid lactones in the treatment of hyperlipidemia
    Patent number: 4965373
    Abstract: Compounds of formula I ##STR1## are described which are useful to inhibit the formation of serum cholesterol by virtue of their ability to inhibit .beta.-hydroxy-.beta.-methylglutaryl-CoA(HMG CoA), the rate-controlling substance in the synthesis of serum cholesterol.
    Type: Grant
    Filed: November 7, 1988
    Date of Patent: October 23, 1990
    Assignee: G. D. Searle & Co.
    Inventors: John S. Baran, Thomas J. Lindberg, Harman S. Lowrie
  • Substituted glutaric acid lactones in the treatment of hyperlipidemia
    Patent number: 4895973
    Abstract: Compounds of formula I ##STR1## are described which are useful to inhibit the formation of serum cholesterol by virtue of their ability to inhibit .beta.-hydroxy-.beta.-methylglutaryl-CoA(HMG CoA), the rate-controlling substance in the synthesis of serum cholesterol.
    Type: Grant
    Filed: December 21, 1988
    Date of Patent: January 23, 1990
    Assignee: G. D. Searle & Company
    Inventors: John S. Baran, Thomas J. Lindberg, Harman S. Lowrie
  • 3-alkyl-5-(substituted amino)methyl)dihydro-3-phenyl-2(3H)-furanones and imino analogs thereof used for treatment of arrhythmia
    Patent number: 4707499
    Abstract: This invention relates to 3-alkyl-5-[(substituted amino) methyl]dihydro-3-phenyl-2(3H)-furanones and imino analogs thereof, and to the pharmaceutical compositions containing such compounds, that are useful as inhibitors of cardiac arrhythmias and are therefore useful in the treatment of irregular heartbeat. This invention also relates to the use of such compounds and pharmaceutical compositions in the treatment of irregular heartbeat.
    Type: Grant
    Filed: December 1, 1986
    Date of Patent: November 17, 1987
    Assignee: G. D. Searle & Co.
    Inventors: John S. Baran, Harman S. Lowrie
  • Pentanedioic acid derivatives
    Patent number: 4645858
    Abstract: Compounds of formula I are described which are useful to inhibit the formation of serum cholesterol by virtue of their ability to inhibit .beta.-hydroxy-.beta.-methylglutaryl-CoA(HMG CoA), the rate-controlling substance in the synthesis of serum cholesterol.
    Type: Grant
    Filed: October 10, 1985
    Date of Patent: February 24, 1987
    Assignee: G. D. Searle & Co.
    Inventors: Harman S. Lowrie, John S. Baran
  • Substituted glutaric acid lactones in the treatment of hyperlipidemia
    Patent number: 4622338
    Abstract: Compounds of formula I ##STR1## are described which are useful to inhibit the formation of serum cholesterol by virtue of their ability to inhibit .beta.-hydroxy-.beta.-methylglutaryl-CoA(HMG CoA), the rate-controlling substance in the synthesis of serum cholesterol.
    Type: Grant
    Filed: March 11, 1985
    Date of Patent: November 11, 1986
    Assignee: G. D. Searle & Co.
    Inventors: John S. Baran, Thomas J. Lindberg, Harman S. Lowrie
  • 3-Substituted pentanedioic acids and derivatives thereof
    Patent number: 4554359
    Abstract: This invention relates to methods of preventing or reducing the degradation of elastin and other proteins and thereby preventing or retarding the disease states caused by said degradation by administering compounds of the formula: ##STR1## or their pharmacologically acceptable salts.
    Type: Grant
    Filed: January 9, 1984
    Date of Patent: November 19, 1985
    Assignee: G. D. Searle & Co.
    Inventors: Harman S. Lowrie, John S. Baran
  • Dihydro azino isoquinolines
    Patent number: 4473501
    Abstract: The invention provides novel 1,5-substituted isoquinoline derivatives of formula I which are useful in the treatment of hypertension.
    Type: Grant
    Filed: December 11, 1981
    Date of Patent: September 25, 1984
    Assignee: G. D. Searle & Co.
    Inventor: Harman S. Lowrie
  • 4-{[4-(Diphenylmethyl)-1-piperidinyl]methyl}benzenamines
    Patent number: 4035372
    Abstract: 4-{[4-(Diphenylmethyl)-1-piperidinyl]methyl}benzenamines useful by reason of their vasodilating activity are disclosed.
    Type: Grant
    Filed: August 13, 1976
    Date of Patent: July 12, 1977
    Assignee: G. D. Searle & Co.
    Inventors: James R. Deason, Robert W. Hamilton, Harman S. Lowrie, Kurt J. Rorig