Patents by Inventor Harmen Slijkhuis

Harmen Slijkhuis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation of 9-.alpha.-hydroxy-17-keto steroids using Mycobacterium species CBS 482.86
    Patent number: 5298398
    Abstract: 9.alpha.-hydroxy-17-keto steroids are prepared by fermenting steroids having a C-17-side chain of 5-10 carbon atoms inclusive, with the novel Mycobacterium species CBS 482.86. Starting from various substrates containing a 5-10 C carbon chain on C-17, 9.alpha.-hydroxyandrost-4-ene-3,17-dione, 7.alpha.,9.alpha.,12.alpha.-trihydroxyandrost-4-ene-3,17-dione or 9.alpha.-hydroxyandrost-4,11-diene-3,17-dione is obtained in high yield. The resulting compounds are useful intermediates in the synthesis of therapeutically important steroids, particularly corticosteroids.
    Type: Grant
    Filed: August 6, 1992
    Date of Patent: March 29, 1994
    Assignee: Gist-Brocades NV
    Inventors: Harmen Slijkhuis, Arthur F. Marx
  • Microbiological preparation of 9-alpha-hydroxy-17-keto steroids
    Patent number: 5166055
    Abstract: 9.alpha.-hydroxy-17-keto steroids are prepared by fermenting steroids having a C-17-side chain of 5-10 carbon atoms inclusive, with the novel Mycobacterium species CBS 482.86.Starting from various substrates containing a 5-10 C carbon chain on C-17, 9.alpha.-hydroxyandrost-4-ene-3,17-dione, 7.alpha.,9.alpha.,12.alpha.-trihydroxyandrost-4-ene-3,17-dione or 9.alpha.-hydroxyandrost-4,11-diene-3,17-dione is obtained in high yield.The resulting compounds are useful intermediates in the synthesis of therapeutically important steroids, particularly corticosteroids.
    Type: Grant
    Filed: July 15, 1991
    Date of Patent: November 24, 1992
    Assignee: Gist-Brocades N.V.
    Inventors: Harmen Slijkhuis, Arthur F. Marx