Abstract: The invention provides an alloy comprising e.g. manganese, iron, vanadium, phosphor and silicon. The invention also provides an apparatus comprising a magnetic field generator, a heat sink, the thermo element, a heat source, and a control system, wherein in a controlling mode the control system is configured to select between (i) a first configuration wherein the magnetic field generator generates a magnetic field, the thermo element is exposed to the magnetic field, and heat from the thermo element is transferred to the heat sink, and (ii) a second configuration, wherein the thermo element is not exposed to the magnetic field, and heat from a heat source is transferred to the thermo element.

Abstract: A blood collection device for the self-collection of a blood sample by a user, wherein, a base element has a width of more than 1.75 in and including an upstanding wall which defines a receive opening, the upstanding wall having a height of less than 1.75 in; a collection container is configured for placement in said receive opening in a substantially upright orientation; the finger portion comprising a blood collection hole that provides a fluid channel between the collection container and the finger portion; wherein at least the base element is a separate part, configured to be shipped in a de-assembled state with respect to the other parts of the blood collection device, wherein the blood collection device is configured to be assembled by a user after receiving said blood collection device.

Abstract: The invention provides an alloy comprising e.g. manganese, iron, vanadium, phosphor and silicon. The invention also provides an apparatus comprising a magnetic field generator, a heat sink, the thermo element, a heat source, and a control system, wherein in a controlling mode the control system is configured to select between (i) a first configuration wherein the magnetic field generator generates a magnetic field, the thermo element is exposed to the magnetic field, and heat from the thermo element is transferred to the heat sink, and (ii) a second configuration, wherein the thermo element is not exposed to the magnetic field, and heat from a heat source is transferred to the thermo element.

Abstract: A method for cleaning a printed band of flexible material, in which at least one side printing ink comprises with a device. The device comprises a cleaning organ such as a brush roll, and the method the steps comprises of the contacting of the band which printing ink comprises with a cleaning liquid, and the removal of the printing ink which been brought into contact the cleaning liquid with the cleaning organ to obtain a cleaned band of flexible material. Before the effective of adhered liquid getting rid of, comprises the device a pair of wiper blades into the direction of transport of the band remotely of one another are located and are for the removal of the cleaning liquid the band at an angle first via an uppermost wiper blade and subsequently via a lowermost wiper blade of the pair fed.

Abstract: A method for cleaning a printed band of flexible material, in which at least one side printing ink comprises with a device. The device comprises a cleaning organ such as a brush roll, and the method the steps comprises of the contacting of the band which printing ink comprises with a cleaning liquid, and the removal of the printing ink which been brought into contact the cleaning liquid with the cleaning organ to obtain a cleaned band of flexible material. Before the effective of adhered liquid getting rid of, comprises the device a pair of wiper blades into the direction of transport of the band remotely of one another are located and are for the removal of the cleaning liquid the band at an angle first via an uppermost wiper blade and subsequently via a lowermost wiper blade of the pair fed.

Abstract: An integrated capillary electrophoresis system comprising a universal interface is disclosed. The universal interface includes one or more of the following structural elements: a chip assembly that receives a capillary electrophoresis CE chip; a fluidic interface for coupling fluids between the chip assembly and external sources or destinations; a first electrical interface for coupling power from an external source to the chip assembly; a second electrical interface for coupling electrical signals from the chip assembly to external analysis electronics; an optical interface for coupling optical signals between the chip assembly and external sources or destinations; and a docking station for uniting and spatially locating the various other structural elements.

Abstract: The invention is in the field of genomics and it provides an in vitro method for predicting whether a compound is genotoxic in vivo. It provides a method that employs the analysis of expression profiles of primary mouse hepatocytes as an in vitro system to discriminate false GTX compounds from true GTX carcinogens. It was found that differential expression of a number of genes could reliably predict whether a compound was a true genotoxic compound.

Abstract: An integrated capillary electrophoresis system comprising a universal interface is disclosed. The universal interface includes one or more of the following structural elements: a chip assembly that receives a capillary electrophoresis CE chip; a fluidic interface for coupling fluids between the chip assembly and external sources or destinations; a first electrical interface for coupling power from an external source to the chip assembly; a second electrical interface for coupling electrical signals from the chip assembly to external analysis electronics; an optical interface for coupling optical signals between the chip assembly and external sources or destinations; and a docking station for uniting and spatially locating the various other structural elements.

Abstract: An integrated capillary electrophoresis system comprising a universal interface is disclosed. The universal interface includes one or more of the following structural elements: a chip assembly that receives a capillary electrophoresis CE chip; a fluidic interface for coupling fluids between the chip assembly and external sources or destinations; a first electrical interface for coupling power from an external source to the chip assembly; a second electrical interface for coupling electrical signals from the chip assembly to external analysis electronics; an optical interface for coupling optical signals between the chip assembly and external sources or destinations; and a docking station for uniting and spatially locating the various other structural elements.

Abstract: The current invention pertains to a method for screening and discovery of compounds capable of inhibiting, preventing, delaying or reducing genome maintenance disorders and consequences thereof, in particular ageing related symptoms and disorders. The current invention provides a method for screening and discovery of compounds that are capable of inhibiting, preventing, delaying or reducing genome maintenance disorders and consequences thereof. The invention exploits animal models that comprise deficiencies in their genome maintenance systems, such as DNA repair systems, and display premature, enhanced, accelerated or segmental ageing phenotypes. These animal models can be advantageously applied to screen compounds and thereby develop schemes of intervention to treat, delay, inhibit, prevent or cure ageing related symptoms. The current invention thus provides a new and powerful tool to screen aid/or discover therapeutically active compounds to treat ageing related symptoms and diseases.

Abstract: A process for the preparation of an alkoxylate composition, said process comprising the steps of: (a) introducing into a reactor system one or more compounds with one or more active hydrogen atoms, selected from the group comprising alkanoic acids, alkanoic amides, alkanoic ethanolamides, alcohols and alkylmercaptans, and a double metal cyanide catalyst; (b) contacting the one or more compounds with one or more active hydrogen atoms and the double metal cyanide catalyst with propylene oxide and/or butylene oxide to form a first product mixture comprising double metal cyanide catalyst and compounds formed by the addition of one of more propylene oxide and/or butylene oxide units to the one or more compounds with one or more active hydrogen atoms; and (c) contacting the first product mixture with ethylene oxide to form a second product mixture comprising compounds formed by the addition of one of more ethylene oxide units to the compounds formed in step (b).

Abstract: A displacement measurement system, in particular for measuring the displacement of a substrate table in a lithographic apparatus relative to a reference frame is presented. The displacement measure system includes a plurality of displacement sensors mounted to the substrate table and a target associated with each displacement sensor mounted to the reference frame.

Abstract: An immersion lithographic projection apparatus is disclosed in which a shutter member is employed to block a liquid supply system during substrate swap to ensure that liquid remains in contact with anl element of the projection system during substrate swap. The shutter member is connected to a metrology frame which also supports the projection system. In this way the position of the shutter member is always known.

Abstract: A moveable member is provided which extends the top surface of a substrate table, in plan, beyond a bumper which protects the substrate table during collision. The moveable member may be retracted to a retracted position in which it no longer extends beyond the bumper. In this way it is possible to move two substrate tables together and to allow the retractable member to pass under a liquid supply system which normally provides liquid between the projection system and a substrate without turning off of the liquid supply system.

Abstract: Embodiments of the invention relates to a substrate handler for handling a substrate, including a conditioning device for conditioning the substrate. In an embodiment, the substrate handler includes a displacing device configured to displace the substrate in a direction substantially parallel to the support surface, wherein the displacing device is configured to displace the substrate during the conditioning process from one conditioning position to one or more other conditioning positions. According to another embodiment of the invention, the substrate handler includes a float device for providing an air bed above a support surface of the substrate handler, the substrate handler being configured to support the substrate on an air bed during conditioning of the substrate.

Abstract: A lithographic apparatus comprises an illumination system, an array of individually controllable elements, a substrate table, a projection system, a position encoder, an imaging device, and an image processing unit. The illumination system conditions a radiation beam. The array of individually controllable elements modulates the cross-section of the radiation beam. The substrate table supports a substrate. The projection system projects the modulated radiation beam onto a target portion of the substrate, thereby applying a pattern to the target portion of the substrate. The pattern comprises a first line and a second line. The first line is offset from the second line. The position encoder determines a position of the substrate table. The position encoder comprises a position sensor and a scale. The scale comprises a plurality of lines intended to be straight and parallel to one another. The imaging device obtains an image of the first line and the second line.

Abstract: A lithographic apparatus has an illumination system that conditions a radiation beam and a patterning device support that supports a patterning device. The patterning device patterns the radiation beam. The lithographic apparatus also has a substrate support that supports a substrate, a machine frame that supports the substrate support, a projection system that projects the patterned beam onto a target portion of the substrate, and a substrate support drive that moves the substrate support in at least one direction. The lithographic apparatus can have a reaction mass, a balance mass, a base frame, where the substrate support drive is configured to generate a force in the at least one direction between the substrate support and the reaction mass, the balance mass, or the support frame.

Abstract: An integrated capillary electrophoresis system comprising a universal interface is disclosed. The universal interface includes one or more of the following structural elements: a chip assembly that receives a capillary electrophoresis CE chip; a fluidic interface for coupling fluids between the chip assembly and external sources or destinations; a first electrical interface for coupling power from an external source to the chip assembly; a second electrical interface for coupling electrical signals from the chip assembly to external analysis electronics; an optical interface for coupling optical signals between the chip assembly and external sources or destinations; and a docking station for uniting and spatially locating the various other structural elements.

Abstract: A substrate handler for moving a substrate relative to a substrate table of a lithographic apparatus. The substrate handler comprises at least one support surface or platform adapted to carry a plurality of independent substrates simultaneously. The substrate handler adapted to load substrates onto and unload substrates from the substrate table before and after exposure.

Abstract: A substrate handler for moving a substrate relative to a substrate table of a lithographic apparatus. The substrate handler comprises at least one support surface or platform adapted to carry a plurality of independent substrates simultaneously. The substrate handler adapted to load substrates onto and unload substrates from the substrate table before and after exposure.