Patents by Inventor Harmon J. Zuccola

Harmon J. Zuccola has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrimidine compounds as tuberculosis inhibitors
    Patent number: 9422271
    Abstract: The present invention relates to compounds useful as inhibitors of treating tuberculosis. The invention also provides processes for preparing compounds of the invention.
    Type: Grant
    Filed: October 31, 2013
    Date of Patent: August 23, 2016
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Tiansheng Wang, Brian Hanzelka, Ute Muh, Guy Bemis, Harmon J. Zuccola
  • PYRIMIDINE COMPOUNDS AS TUBERCULOSIS INHIBITORS
    Publication number: 20140249137
    Abstract: The present invention relates to compounds useful as inhibitors of treating tuberculosis.
    Type: Application
    Filed: October 31, 2013
    Publication date: September 4, 2014
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Tiansheng Wang, Brian Hanzelka, Ute Muh, Guy Bemis, Harmon J. Zuccola
  • STRUCTURE-BASED APPROACH TO DESIGN OF INHIBITORS OF PROTEIN-PROCESSIVITY FACTOR INTERACTIONS
    Publication number: 20100298164
    Abstract: A method for the structure-based identification and selection of inhibitors of processivity factor binding to protein is disclosed herein. Characterization of the protein/processivity factor interface is given. Methods for the structure-based inhibition of processivity factor binding to protein are also given. One embodiment includes a class of peptidomimetics that mimic helical portions of proteins. In addition, methods of treatment of various diseases are given, using the inhibitors of the invention.
    Type: Application
    Filed: July 2, 2010
    Publication date: November 25, 2010
    Inventors: Donald Coen, James Hogle, Carl Elkin, Harmon J. Zuccola, Kristie Grove Bridges, Scott Lokey
  • Structure-based approach to design of inhibitors of protein-processivity factor interactions
    Patent number: 7388070
    Abstract: A method for the structure-based identification and selection of inhibitors of processivity factor binding to protein is disclosed herein. Characterization of the protein/processivity factor interface is given. Methods for the structure-based inhibition of processivity factor binding to protein are also given. One embodiment includes a class of peptidomimetics that mimic helical portions of proteins. In addition, methods of treatment of various diseases are given, using the inhibitors of the invention.
    Type: Grant
    Filed: May 12, 2000
    Date of Patent: June 17, 2008
    Assignee: President and Fellows of Harvard College
    Inventors: Donald Coen, James Hogle, Carl Elkin, Harmon J. Zuccola, Kristie Grove Bridges, Scott Lokey
  • Oligomerization of hepatitis delta antigen
    Patent number: 6844171
    Abstract: This invention relates to HDAg peptides, including mutants, derivatives fragments and fusion molecules, including fusion proteins, coiled-coil oligomers, nucleic acid molecules, vectors comprising HDAg nucleic acid molecules, cells comprising said molecules, methods of multivalent expression and association of binding moieties of HDAg fusion molecules, and methods of use involving the molecules. The molecules are particularly useful as a framework for multivalent display via formation of C-terminal and/or N-terminal fusion proteins or via chemical coupling to chemically reactive sidechains, e.g. cysteine residues.
    Type: Grant
    Filed: July 1, 1999
    Date of Patent: January 18, 2005
    Assignee: President and Fellows of Harvard College
    Inventors: James M. Hogle, Harmon J. Zuccola, David Filman, Carl Elkin